Next Article in Journal
Role and Therapeutic Targeting of the HGF/MET Pathway in Glioblastoma
Next Article in Special Issue
Significance of microRNAs in Androgen Signaling and Prostate Cancer Progression
Previous Article in Journal
Potential of Integrin Inhibitors for Treating Ovarian Cancer: A Literature Review
Previous Article in Special Issue
Specific Depletion of Leukemic Stem Cells: Can MicroRNAs Make the Difference?
Article Menu
Issue 7 (July) cover image

Export Article

Open AccessReview
Cancers 2017, 9(7), 85;

The Role of miRNAs in Angiogenesis, Invasion and Metabolism and Their Therapeutic Implications in Gliomas

Department of Radiation Oncology, the Ohio State University Comprehensive Cancer Center & Arthur, G. James Cancer Hospital, Columbus, OH 43012, USA
Author to whom correspondence should be addressed.
Academic Editors: Takahiro Ochiya and Ryou-u Takahashi
Received: 31 May 2017 / Revised: 1 July 2017 / Accepted: 3 July 2017 / Published: 10 July 2017
Full-Text   |   PDF [1045 KB, uploaded 10 July 2017]   |  


MicroRNAs (miRNAs) are small, non-coding, endogenous RNA molecules that function in gene silencing by post-transcriptional regulation of gene expression. The dysregulation of miRNA plays a pivotal role in cancer tumorigenesis, including the development and progression of gliomas. Their small size, stability and ability to target multiple oncogenes have simultaneously distinguished miRNAs as attractive candidates for biomarkers and novel therapeutic targets for glioma patients. In this review, we summarize the most frequently cited miRNAs known to contribute to gliomagenesis and progression by regulating the defining hallmarks of gliomas, including angiogenesis, invasion, and cell metabolism. We also discuss their promising potential as prognostic and predictive biomarkers and novel therapeutic targets, in addition to the challenges that must be overcome before their translation from bench to bedside. View Full-Text
Keywords: glioma; glioblastoma; miRNA; angiogenesis; invasion; cell metabolism glioma; glioblastoma; miRNA; angiogenesis; invasion; cell metabolism

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Beyer, S.; Fleming, J.; Meng, W.; Singh, R.; Haque, S.J.; Chakravarti, A. The Role of miRNAs in Angiogenesis, Invasion and Metabolism and Their Therapeutic Implications in Gliomas. Cancers 2017, 9, 85.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top