Situational Awareness: Regulation of the Myb Transcription Factor in Differentiation, the Cell Cycle and Oncogenesis
by
Olivia L. George † and Scott A. Ness *
Olivia L. George † and Scott A. Ness *
Department of Internal Medicine, Section of Molecular Medicine, University of New Mexico Health Sciences Center, MSC07 4025—CRF 121, 1 University of New Mexico, Albuquerque, NM 87131, USA
*
Author to whom correspondence should be addressed.
†
Current address: Department of Humanities/Biology, University of Hawaii, West Oahu, 91-1001 Farrington Highway, Kapolei, HI 96707, USA.
Cancers 2014, 6(4), 2049-2071; https://doi.org/10.3390/cancers6042049
Received: 4 May 2014 / Revised: 11 August 2014 / Accepted: 26 September 2014 / Published: 2 October 2014
(This article belongs to the Special Issue Cell Cycle Deregulation in Cancers)
This review summarizes the mechanisms that control the activity of the c-Myb transcription factor in normal cells and tumors, and discusses how c-Myb plays a role in the regulation of the cell cycle. Oncogenic versions of c-Myb contribute to the development of leukemias and solid tumors such as adenoid cystic carcinoma, breast cancer and colon cancer. The activity and specificity of the c-Myb protein seems to be controlled through changes in protein-protein interactions, so understanding how it is regulated could lead to the development of novel therapeutic strategies.
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Keywords:
chromatin; gene regulation; cyclins; post-translational modifications; cancer; salivary gland; epithelia; differentiation; RNA splicing; signaling
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
George, O.L.; Ness, S.A. Situational Awareness: Regulation of the Myb Transcription Factor in Differentiation, the Cell Cycle and Oncogenesis. Cancers 2014, 6, 2049-2071.
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