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Alterations of 5-Hydroxymethylcytosine in Human Cancers

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Section of Hematology/Oncology, Department of Medicine, The University of Chicago, 5841 S. Maryland Ave., MC 2115, Chicago, IL 60637, USA
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Committee on Molecular Pathogenesis and Molecular Medicine, The University of Chicago, Chicago, IL 60637, USA
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Committee on Cancer Biology, The University of Chicago, Chicago, IL 60637, USA
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Author to whom correspondence should be addressed.
Cancers 2013, 5(3), 786-814; https://doi.org/10.3390/cancers5030786
Received: 26 March 2013 / Revised: 16 May 2013 / Accepted: 29 May 2013 / Published: 25 June 2013
(This article belongs to the Special Issue Cancer Epigenetics)
Prior to 2009, 5-methylcytosine (5-mC) was thought to be the only biologically significant cytosine modification in mammalian DNA. With the discovery of the TET enzymes, which convert 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC), however, intense interest has emerged in determining the biological function of 5-hmC. Here, we review the techniques used to study 5-hmC and evidence that alterations to 5-hmC physiology play a functional role in the molecular pathogenesis of human cancers. View Full-Text
Keywords: 5-hydroxymethylcytosine; 5-methylcytosine; cancer; DNA methylation; epigenetics; ten-eleven translocation; TET 5-hydroxymethylcytosine; 5-methylcytosine; cancer; DNA methylation; epigenetics; ten-eleven translocation; TET
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Mariani, C.J.; Madzo, J.; Moen, E.L.; Yesilkanal, A.; Godley, L.A. Alterations of 5-Hydroxymethylcytosine in Human Cancers. Cancers 2013, 5, 786-814.

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