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Cancers 2011, 3(2), 1877-1898;

Recent Advance in Biosensors for microRNAs Detection in Cancer

Istituto per l’Endocrinologia e l’Oncologia Sperimentale del CNR ‘‘G. Salvatore’’, Via S. Pansini 5, 80131 Naples, Italy
Dipartimento di Biologia e Patologia Cellulare e Molecolare, University of Naples “Federico II”, Naples, Italy
Facolta di Scienze Biotecnologiche, University of Naples ‘‘Federico II’’, Naples, Italy
These authors contributed equally to the work.
Author to whom correspondence should be addressed.
Received: 27 January 2011 / Revised: 25 March 2011 / Accepted: 1 April 2011 / Published: 8 April 2011
(This article belongs to the Special Issue Cancer Diagnosis and Targeted Therapy)
Full-Text   |   PDF [581 KB, uploaded 8 April 2011]


MicroRNAs (miRNAs) are short non-protein-coding RNA molecules that regulate the expression of a wide variety of genes. They act by sequence-specific base pairing in the 3’ untranslated region (3’UTR) of the target mRNA leading to mRNA degradation or translation inhibition. Recent studies have implicated miRNAs in a wide range of biological processes and diseases including development, metabolism and cancer, and revealed that expression levels of individual miRNAs may serve as reliable molecular biomarkers for cancer diagnosis and prognosis. Therefore, a major challenge is to develop innovative tools able to couple high sensitivity and specificity for rapid detection of miRNAs in a given cell or tissue. In this review, we focus on the latest innovative approaches proposed for miRNA profiling in cancer and discuss their advantages and disadvantages. View Full-Text
Keywords: microRNA; biomarker; cancer microRNA; biomarker; cancer
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Catuogno, S.; Esposito, C.L.; Quintavalle, C.; Cerchia, L.; Condorelli, G.; De Franciscis, V. Recent Advance in Biosensors for microRNAs Detection in Cancer. Cancers 2011, 3, 1877-1898.

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