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Cancers 2010, 2(3), 1379-1404;

The Changing Face of Esophageal Cancer

Academic Department of Surgery, Queen Elizabeth Hospital, University Hospitals Birmingham, Birmingham, UK
Author to whom correspondence should be addressed.
Received: 17 June 2010 / Revised: 24 June 2010 / Accepted: 24 June 2010 / Published: 28 June 2010
(This article belongs to the Special Issue Epidemiologic Research and Cancer)
Full-Text   |   PDF [304 KB, uploaded 28 June 2010]   |  


The two main histological esophageal cancer types, adenocarcinoma and squamous cell carcinoma, differ in incidence, geographic distribution, ethnic pattern and etiology. This article focuses on epidemiology with particular reference to geographic and temporal variations in incidence, along with a review of the evidence supporting environmental and genetic factors involved in esophageal carcinogenesis. Squamous cell carcinoma of the esophagus remains predominantly a disease of the developing world. In contrast, esophageal adenocarcinoma is mainly a disease of western developed societies, associated with obesity and gastro-esophageal reflux disease. There has been a dramatic increase in the incidence of adenocarcinoma in developed countries in parallel with migration of both esophageal and gastric adenocarcinomas towards the gastro-esophageal junction. View Full-Text
Keywords: esophageal carcinoma; esophageal adenocarcinoma; esophageal squamous cell carcinoma; epidemiology; risk factors esophageal carcinoma; esophageal adenocarcinoma; esophageal squamous cell carcinoma; epidemiology; risk factors

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Melhado, R.E.; Alderson, D.; Tucker, O. The Changing Face of Esophageal Cancer. Cancers 2010, 2, 1379-1404.

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