Esophagectomy Versus Endoscopic Resection with Adjuvant Therapy for T1b/T2 Esophageal Cancer: A Systematic Review and Meta-Analysis
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Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 3H2, Canada
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Department of Internal Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3A 1R9, Canada
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Michigan State University College of Osteopathic Medicine, Michigan State University, East Lansing, MI 48824, USA
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Section of Thoracic Surgery, Department of Surgery, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3A 1R9, Canada
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CancerCare Manitoba Research Institute, University of Manitoba, Winnipeg, MB R3E 0V9, Canada
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Department of Physiology & Pathophysiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada
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Department of Biomedical Engineering, University of Manitoba, Winnipeg, MB R3T 5V6, Canada
*
Author to whom correspondence should be addressed.
Cancers 2025, 17(4), 680; https://doi.org/10.3390/cancers17040680
Submission received: 6 January 2025
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Revised: 13 February 2025
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Accepted: 13 February 2025
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Published: 17 February 2025
(This article belongs to the Special Issue Oesogastric Cancer: Treatment and Management)
Simple Summary
Surgical removal of the esophagus is the most recommended treatment for patients with early-stage T1b/T2 esophagus cancer. This surgery involves cutting out the esophagus and a part of the stomach to make a new esophagus. This has a high risk for harmful complications. The aim of this study was to assess if partial removal with endoscopy followed by additional therapy (like chemotherapy/radiation) could be a suitable alternative to surgery. We devised a search protocol and review process according to standardized guidelines to find studies of patients undergoing endoscopic removal followed by additional therapy. Information about survival and complications from these studies was collected and analyzed. The combined information showed that 5-year survival was similar between the two treatments. Patients undergoing endoscopic resection with additional therapy experienced fewer complications. Therefore, endoscopic removal followed by additional therapy could be a suitable alternative to surgical removal in patients with T1b/T2 esophagus cancer. Clinical trials are required.
Excerpt
Note: In lieu of an abstract, this is an excerpt from the first page.
Esophageal cancer is the seventh most common cause of cancer-related death worldwide [...]
