Evaluating the Impact of Weekly Physical Performance Reports on Daily Physical Activity and Symptoms Among Cancer Survivors: Secondary Analysis of a Randomized Controlled Trial
Simple Summary
Abstract
1. Introduction
2. Method
2.1. Parent Trial Overview
2.2. Secondary Analysis Methods
2.2.1. Design
2.2.2. Sample and Setting
2.2.3. Data Source
2.2.4. Measures and Outcomes
2.3. Data Analysis
3. Results
3.1. Sample Characteristics
3.2. Effect of Weekly Physical Performance Reports
3.3. Relationships Between Changes in Daily Physical Activity, Sleep, and Symptoms
3.4. Effect of Baseline Characteristics on Relationships Among Physical Activity, Sleep, and Symptoms
4. Discussion
Limitations
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Variables | n | % |
---|---|---|
Age, (mean ± SD) | 59.79 ± 12.17 | |
Gender | ||
Male | 45 | 58.4 |
Female | 32 | 41.6 |
Race | ||
White | 67 | 87.0 |
Black or African American | 4 | 5.2 |
Others | 6 | 7.8 |
Ethnicity | ||
Hispanic or Latino | 4 | 5.2 |
Not Hispanic or Latino | 68 | 88.3 |
Unknown | 5 | 6.5 |
Estimated Annual Household Income | ||
<$75,000 | 9 | 11.7 |
≥$75,000 | 68 | 88.3 |
Education | ||
≤High School Graduate | 3 | 3.9 |
Some College | 12 | 15.6 |
College/Postgraduate | 62 | 80.5 |
Primary Caregiver | ||
Self | 69 | 89.6 |
Significant others | 8 | 10.4 |
Employment | ||
Employed | 38 | 49.4 |
Non-employed | 39 | 50.6 |
Marital Status | ||
Married/Domestic partnership | 64 | 83.1 |
Not married | 13 | 16.9 |
Cancer Type | ||
Breast cancer | 15 | 19.5 |
Prostate cancer | 26 | 33.8 |
Others | 36 | 46.7 |
Undergoing Chemotherapy | ||
Yes | 9 | 11.7 |
No | 68 | 88.3 |
Undergoing Radiation | ||
Yes | 3 | 3.9 |
No | 74 | 96.1 |
Undergoing Hormonal therapy | ||
Yes | 16 | 20.8 |
No | 61 | 79.2 |
Undergoing Immunotherapy | ||
Yes | 14 | 18.2 |
No | 63 | 81.8 |
Comorbidity | ||
Yes | 75 | 97.4 |
No | 2 | 2.6 |
Baseline average step counts/day (mean ± SD) | 6376.77 ± 4374.17 | |
Baseline average sleep hour/day, (mean ± SD) | 5.88 ± 2.87 | |
Baseline pain severity, (mean ± SD) | 2.32 ± 2.69 | |
Baseline low energy severity, (mean ± SD) | 4.61 ± 2.27 | |
Baseline sleep difficulty severity, (mean ± SD) | 3.74 ± 2.75 | |
Baseline mood disturbances severity, (mean ± SD) | 2.64 ± 2.70 |
Outcomes and Predictors | Coefficient (95% CI) | p | ||
---|---|---|---|---|
Physical activity | time a | −4.327 (−15.9498, 7.2957) | 0.466 | |
Reports b | 140.857 (16.1327, 265.5820) | 0.027 * | ||
Reports × time c | −2.034 (−4.6278, 0.5613) | 0.125 | ||
Sleep | Time | −0.398 (−0.8378, 0.0427) | 0.077 | |
Reports | 1.109 (−3.6311, 5.8484) | 0.647 | ||
Reports × time | 0.043 (−0.0557, 0.1410) | 0.395 | ||
Symptoms | Pain | time | −0.002 (−0.0029, 0.0003) | 0.113 |
Reports | −0.002 (−0.0243, 0.0203) | 0.856 | ||
Reports × time | 9.530 × 10−6 (−0.004, 0.0004) | 0.960 | ||
Low energy | time | −0.003 (−0.0047, −0.0009) | 0.004 * | |
Reports | 0.002 (−0.0186, 0.0225) | 0.850 | ||
Reports × time | 4.510 × 10−5 (−0.0003, 0.0004) | 0.818 | ||
Sleep difficulty | time | −0.002 (−0.0043, 0.0002) | 0.074 | |
Reports | 0.011 (−0.0111, 0.0340) | 0.314 | ||
Reports × time | −1.521 × 10−5 (−0.0006, 0.0003) | 0.527 | ||
Mood disturbances | time | −6.568 × 10−4 (−0.0020, 0.0007) | 0.327 | |
Reports | −1.285 × 10−4 (−0.0165, 0.0163) | 0.987 | ||
Reports × time | −1.700 × 10−5 (−0.0004, 0.0003) | 0.920 |
Outcomes | Predictors | Coefficient | SE | 95% CI | t | p | F | |
---|---|---|---|---|---|---|---|---|
Symptoms | Pain | Step_lag d | −0.047 *** | 0.011 | (−0.07, −0.02) | −4.16 | <0.001 | 15.13 (p < 0.001) |
Sleep_lag e | 0.029 ** | 0.009 | (0.01, 0.05) | 3.30 | 0.001 | |||
Low energy | Step_lag | −0.082 *** | 0.012 | (−0.11, −0.06) | −7.03 | <0.001 | 32.04 (p < 0.001) | |
Sleep_lag | 0.027 ** | 0.009 | (0.01, 0.04) | 3.12 | 0.002 | |||
Sleep difficulty | Step_lag | −0.206 | 0.013 | (−0.05, −0.01) | −1.62 | 0.106 | 2.18 (p = 0.114) | |
Sleep_lag | 0.117 | 0.010 | (−0.01, −0.03) | 1.18 | 0.240 | |||
Mood disturbances | Step_lag | −2.079 × 10−4 | 0.009 | (−0.02, 0.19) | −0.02 | 0.982 | 0.10 (p = 0.901) | |
Sleep_lag | 0.003 | 0.007 | (−0.01, 0.02) | 0.48 | 0.633 |
Symptoms | Moderators | Coefficient | SE | 95% CI | t | p |
---|---|---|---|---|---|---|
Pain | Employment × Step_lag (reference: employed) | |||||
non-employed | −0.048 | 0.021 | (−0.0890, −0.0078) | −2.34 | 0.020 * | |
Gender × Step_lag (reference: male) | ||||||
female | −0.039 | 0.019 | (−0.0757, −0.0016) | −2.04 | 0.041 * | |
Race × Step_lag (reference: white) | ||||||
Black or African American | 0.009 | 0.690 | (−0.1263, 0.1441) | 0.13 | 0.897 | |
Others | −0.086 | 0.044 | (−0.1725, 0.0001) | −1.96 | 0.050 * | |
Caregiver × Step_lag (reference: self) | ||||||
Significant others | 0.078 | 0.031 | (0.1800, 0.1381) | 2.55 | 0.011 * | |
Step_baseline × Step_lag | −0.037 | 0.012 | (−0.0600, −0.0132) | −3.06 | 0.002 ** | |
Low energy | Employment × Step_lag (reference: employed) | |||||
non-employed | 0.001 | 2.96 × 10−4 | (0.0001, 0.0012) | 2.16 | 0.030 * | |
Gender × Sleep_lag (reference: male) | ||||||
female | −0.001 | 3.08 × 10−4 | (−0.0015, −0.0003) | −2.99 | 0.003 ** | |
Race × Sleep_lag (reference: white) | ||||||
Black or African American | 0.085 | 0.114 | (−0.1388, 0.3080) | 0.74 | 0.458 | |
Others | 0.072 | 0.036 | (0.0022, 0.1425) | 2.02 | 0.043 * | |
Caregiver × Sleep_lag (reference: self) | ||||||
Significant others | 0.059 | 0.024 | (0.0114, 0.1059) | 2.43 | 0.015 * | |
Income × Step_lag (reference: <$75,000) | ||||||
≥$75,000 | −0.131 | 0.042 | (−0.2140, −0.0476) | −3.08 | 0.002 ** | |
Chemotherapy × Sleep_lag | 0.002 | 2.47 × 10−4 | (0.0006, 0.0024) | 3.32 | 0.001 ** | |
Hormonal therapy × Sleep_lag | 0.001 | 3.81 × 10−4 | (0.0001, 0.0016) | 2.23 | 0.026 * |
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Li, M.; Benjasirisan, C.; Zhang, J.; Sheng, J.Y.-S.; Li, J.; Allgood, S.; Carducci, M.; Thrul, J.; Lukkahatai, N. Evaluating the Impact of Weekly Physical Performance Reports on Daily Physical Activity and Symptoms Among Cancer Survivors: Secondary Analysis of a Randomized Controlled Trial. Cancers 2025, 17, 2850. https://doi.org/10.3390/cancers17172850
Li M, Benjasirisan C, Zhang J, Sheng JY-S, Li J, Allgood S, Carducci M, Thrul J, Lukkahatai N. Evaluating the Impact of Weekly Physical Performance Reports on Daily Physical Activity and Symptoms Among Cancer Survivors: Secondary Analysis of a Randomized Controlled Trial. Cancers. 2025; 17(17):2850. https://doi.org/10.3390/cancers17172850
Chicago/Turabian StyleLi, Mingfang, Chitchanok Benjasirisan, Jingyu Zhang, Jennifer Yeong-Shin Sheng, Junxin Li, Sarah Allgood, Michael Carducci, Johannes Thrul, and Nada Lukkahatai. 2025. "Evaluating the Impact of Weekly Physical Performance Reports on Daily Physical Activity and Symptoms Among Cancer Survivors: Secondary Analysis of a Randomized Controlled Trial" Cancers 17, no. 17: 2850. https://doi.org/10.3390/cancers17172850
APA StyleLi, M., Benjasirisan, C., Zhang, J., Sheng, J. Y.-S., Li, J., Allgood, S., Carducci, M., Thrul, J., & Lukkahatai, N. (2025). Evaluating the Impact of Weekly Physical Performance Reports on Daily Physical Activity and Symptoms Among Cancer Survivors: Secondary Analysis of a Randomized Controlled Trial. Cancers, 17(17), 2850. https://doi.org/10.3390/cancers17172850