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Correction

Correction: Kalisvaart et al. Relative Wash-In Rate in Dynamic Contrast-Enhanced Magnetic Resonance Imaging as a New Prognostic Biomarker for Event-Free Survival in 82 Patients with Osteosarcoma: A Multicenter Study. Cancers 2024, 16, 1954

by
Gijsbert M. Kalisvaart
1,†,
Richard E. Evenhuis
2,*,†,
Willem Grootjans
1,
Thomas Van Den Berghe
3,
Martijn Callens
3,
Judith V. M. G. Bovée
4,
David Creytens
5,
Hans Gelderblom
6,
Frank M. Speetjens
6,
Lore Lapeire
7,
Gwen Sys
8,
Marta Fiocco
9,10,11,
Koenraad L. Verstraete
3,
Michiel A. J. van de Sande
2,10 and
Johan L. Bloem
1
1
Department of Radiology, Leiden University Medical Center, 2333 Leiden, The Netherlands
2
Department of Orthopedic Surgery, Leiden University Medical Center, Albinusdreef 2, 2333 Leiden, The Netherlands
3
Department of Radiology, Ghent University Hospital, 9000 Ghent, Belgium
4
Department of Pathology, Leiden University Medical Center, 2333 Leiden, The Netherlands
5
Department of Pathology, Ghent University Hospital, 9000 Ghent, Belgium
6
Department of Medical Oncology, Leiden University Medical Center, 2333 Leiden, The Netherlands
7
Department of Medical Oncology, Ghent University Hospital, 9000 Ghent, Belgium
8
Department of Orthopedic Surgery and Traumatology, Ghent University Hospital, 9000 Ghent, Belgium
9
Department of Biomedical Science, Section Medical Statistics, Leiden University Medical Center, 2333 Leiden, The Netherlands
10
Center for Pediatric Oncology, Princess Maxima Center, 3584 Utrecht, The Netherlands
11
Mathematical Institute, Leiden University, 2300 Leiden, The Netherlands
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Cancers 2025, 17(16), 2603; https://doi.org/10.3390/cancers17162603
Submission received: 28 July 2025 / Accepted: 30 July 2025 / Published: 8 August 2025
(This article belongs to the Section Clinical Research of Cancer)

Error in Figure 2

In the original publication [1], there was a mistake in the legend of Figure 2 as published. In the original version the legend wrongly states the red line accounts for patients with ‘rWIR ≥ 2.3 (good response),’ whereas it actually accounts for patients with poor response. The corrected Figure 2 appears below.

Error in Figure 3

In the original publication, there was a mistake in the legend of Figure 3 as published. In the original version the legend wrongly states the red line accounts for patients with ‘rWIR ≥ 2.3 (good response),’ whereas it actually accounts for patients with poor response. The corrected Figure 3 appears below.

Error in Table 2

In the original publication, there was a mistake in Table 2 as published. The fourth column of the original table wrongly defines good and poor radiological responders. rWIR < 2.3 should define poor response and rWIR ≥ 2.3 should define good response. The corrected Table 2 appears below.

Error in Table 3

In the original publication, there was a mistake in Table 3 as published. The fourth column of the original table wrongly defines good and poor radiological responders. rWIR < 2.3 should define poor response and rWIR ≥ 2.3 should define good response. The corrected Table 3 appears below.
The authors state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.

Reference

  1. Kalisvaart, G.M.; Evenhuis, R.E.; Grootjans, W.; Van Den Berghe, T.; Callens, M.; Bovée, J.V.M.G.; Creytens, D.; Gelderblom, H.; Speetjens, F.M.; Lapeire, L.; et al. Relative Wash-In Rate in Dynamic Contrast-Enhanced Magnetic Resonance Imaging as a New Prognostic Biomarker for Event-Free Survival in 82 Patients with Osteosarcoma: A Multicenter Study. Cancers 2024, 16, 1954. [Google Scholar] [CrossRef] [PubMed]
Figure 2. Estimated event-free survival among good and poor responders based on the rWIR with a cut-off of 2.3.
Figure 2. Estimated event-free survival among good and poor responders based on the rWIR with a cut-off of 2.3.
Cancers 17 02603 g001
Figure 3. Estimated event-free survival among good and poor responders based on the rWIR with a cut-off of 2.3 in a subpopulation of 70 patients without metastases at presentation.
Figure 3. Estimated event-free survival among good and poor responders based on the rWIR with a cut-off of 2.3 in a subpopulation of 70 patients without metastases at presentation.
Cancers 17 02603 g002
Table 2. Hazard ratios (HRs) along with the 95% confidence intervals using multivariate Cox regression models for EFS in a study population (n = 82), with prognostic factors including histological response (left), rWIR as a binary variable (middle), and rWIR as a continuous variable (right) as the prognostic factors.
Table 2. Hazard ratios (HRs) along with the 95% confidence intervals using multivariate Cox regression models for EFS in a study population (n = 82), with prognostic factors including histological response (left), rWIR as a binary variable (middle), and rWIR as a continuous variable (right) as the prognostic factors.
FactorsHR95% CIFactorsHR95% CIFactorsHR95% CI
Age Group Age group Age Group
ChildrenRef ChildrenRef ChildrenRef
AYA1.360.61–3.03AYA1.430.64–3.22AYA1.320.59–2.98
Older adults1.260.45–3.55Older adults1.550.55–4.41Older adults1.410.50–3.97
Tumour size Tumour size Tumour size
Small ≤ 8 cmRef Small ≤ 8 cmRef Small ≤ 8 cmRef
Large > 8 cm0.900.46–2.00Large > 8 cm0.970.47–2.00Large > 8 cm0.960.46–2.01
Histological response to CTx DCE-MRI response (binary) to CTx DCE-MRI response
Good response (<10% viable tum. cells)Ref Good response (rWIR ≥ 2.3)Ref (continuous) to CTx0.780.60–1.01
Poor response (≥10% viable tum. cells)1.820.86–3.84Poor response (rWIR < 2.3)2.391.14–5.01
Metastases at presentation Metastases at presentation Metastases at presentation
NoRef NoRef NoRef
Yes2.290.90–5.83Yes2.310.90–5.92Yes1.850.70–4.94
HR = hazard ratio; ref = reference category; 95% CI = 95% confidence interval; CTx = chemotherapy; DCE-MRI = dynamic contrast-enhanced magnetic resonance imaging; AYA = adolescents and young adults; and rWIR = relative wash-in rate.
Table 3. Hazard ratios (HRs) along with the 95% confidence intervals using multivariate Cox regression models for EFS with prognostic factors including histological response (left), rWIR as a binary variable (middle), and rWIR as a continuous variable (right) as the prognostic factors in a subpopulation of 70 patients without metastases at presentation.
Table 3. Hazard ratios (HRs) along with the 95% confidence intervals using multivariate Cox regression models for EFS with prognostic factors including histological response (left), rWIR as a binary variable (middle), and rWIR as a continuous variable (right) as the prognostic factors in a subpopulation of 70 patients without metastases at presentation.
FactorsHR95% CIFactorsHR95% CIFactorsHR95% CI
Age group Age group Age group
ChildrenRef ChildrenRef ChildrenRef
AYA1.430.59–3.46AYA1.460.61–3.53AYA1.280.53–3.13
Older adults2.110.66–6.79Older adults2.300.74–7.21Older adults2.020.63–6.50
Tumour size Tumour size Tumour size
Small ≤ 8 cmRef Small ≤ 8 cmRef Small ≤ 8 cmRef
Large > 8 cm1.260.55–2.92Large > 8 cm1.330.60–2.97Large > 8 cm1.230.54–2.80
Histological response to CTx DCE-MRI response (binary) to CTx DCE-MRI response (continuous) to
Good responder (<10% viable cells)Ref Good responder (rWIR ≥ 2.3)Ref CTx0.690.50–0.94
Poor responder (≥10% viable cells)1.980.84–4.67Poor responder (rWIR < 2.3)2.281.00–5.19
HR = hazard ratio; ref = reference category; 95% CI = 95% confidence interval; CTx = chemotherapy; DCE-MRI = dynamic contrast-enhanced magnetic resonance imaging; AYA = adolescents and young adults; and rWIR = relative wash-in rate.
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MDPI and ACS Style

Kalisvaart, G.M.; Evenhuis, R.E.; Grootjans, W.; Van Den Berghe, T.; Callens, M.; Bovée, J.V.M.G.; Creytens, D.; Gelderblom, H.; Speetjens, F.M.; Lapeire, L.; et al. Correction: Kalisvaart et al. Relative Wash-In Rate in Dynamic Contrast-Enhanced Magnetic Resonance Imaging as a New Prognostic Biomarker for Event-Free Survival in 82 Patients with Osteosarcoma: A Multicenter Study. Cancers 2024, 16, 1954. Cancers 2025, 17, 2603. https://doi.org/10.3390/cancers17162603

AMA Style

Kalisvaart GM, Evenhuis RE, Grootjans W, Van Den Berghe T, Callens M, Bovée JVMG, Creytens D, Gelderblom H, Speetjens FM, Lapeire L, et al. Correction: Kalisvaart et al. Relative Wash-In Rate in Dynamic Contrast-Enhanced Magnetic Resonance Imaging as a New Prognostic Biomarker for Event-Free Survival in 82 Patients with Osteosarcoma: A Multicenter Study. Cancers 2024, 16, 1954. Cancers. 2025; 17(16):2603. https://doi.org/10.3390/cancers17162603

Chicago/Turabian Style

Kalisvaart, Gijsbert M., Richard E. Evenhuis, Willem Grootjans, Thomas Van Den Berghe, Martijn Callens, Judith V. M. G. Bovée, David Creytens, Hans Gelderblom, Frank M. Speetjens, Lore Lapeire, and et al. 2025. "Correction: Kalisvaart et al. Relative Wash-In Rate in Dynamic Contrast-Enhanced Magnetic Resonance Imaging as a New Prognostic Biomarker for Event-Free Survival in 82 Patients with Osteosarcoma: A Multicenter Study. Cancers 2024, 16, 1954" Cancers 17, no. 16: 2603. https://doi.org/10.3390/cancers17162603

APA Style

Kalisvaart, G. M., Evenhuis, R. E., Grootjans, W., Van Den Berghe, T., Callens, M., Bovée, J. V. M. G., Creytens, D., Gelderblom, H., Speetjens, F. M., Lapeire, L., Sys, G., Fiocco, M., Verstraete, K. L., Sande, M. A. J. v. d., & Bloem, J. L. (2025). Correction: Kalisvaart et al. Relative Wash-In Rate in Dynamic Contrast-Enhanced Magnetic Resonance Imaging as a New Prognostic Biomarker for Event-Free Survival in 82 Patients with Osteosarcoma: A Multicenter Study. Cancers 2024, 16, 1954. Cancers, 17(16), 2603. https://doi.org/10.3390/cancers17162603

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