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Volume 17
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Article

Diagnostic System for Early In Situ Melanoma Detection Using Acoustic Microscopy and Infrared Spectroscopic Mapping Imaging

by
Georgios th Karagiannis
1,2,*,
Ioannis Grivas
3,
Anastasia Tsingotjidou
3,
Georgios Apostolidis
1,2,
Eirini Tsardaka
1,
Ioanna Dori
3,
Kyriaki-Nefeli Poulatsidou
4,
Ioannis Tsougos
5,
Stefan Wesarg
6,
Argyrios Doumas
7 and
Panagiotis Georgoulias
5
1
“ORMYLIA” Foundation, 63071 Ormylia, Greece
2
Diagnosis Multisystems, 63200 Nea Moudania, Greece
3
Laboratory of Anatomy, Histology and Embryology, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
4
Laboratory of Experimental Neurology and Neuroimmunology, Medical School, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
5
Medical School, University of Thessaly, 41334 Larissa, Greece
6
Competence Center Visual Healthcare Technologies of Fraunhofer IGD, 64283 Darmstadt, Germany
7
Radiology-Medical Physics and Informatics Sector, Medical School, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
*
Author to whom correspondence should be addressed.
Cancers 2025, 17(15), 2599; https://doi.org/10.3390/cancers17152599 (registering DOI)
Submission received: 16 October 2024 / Revised: 9 June 2025 / Accepted: 24 June 2025 / Published: 7 August 2025
(This article belongs to the Special Issue Advanced Diagnostics and Optical Imaging Technologies in Cancer Research)
Versions Notes

Simple Summary

This study presents a new noninvasive method for early detection of skin cancer (melanoma), combining acoustic microscopy and infrared spectroscopy. Acoustic microscopy uses sound waves to capture detailed images of the tumor’s structure, while infrared spectroscopy analyzes chemical changes. Researchers tested this technique on animal models resembling human melanoma. The findings show that high-frequency acoustic imaging (>20 MHz) combined with spectroscopy provides clear, accurate, and detailed three-dimensional images of tumors at early stages. Histological tests confirmed the cancerous nature of the tumors, proving this approach could significantly improve early melanoma diagnosis in dermatology.

Abstract

This study proposes a novel diagnostic system for the early detection of cutaneous melanoma based on morphological and biochemical changes during tumor formation. The methods used in this system are acoustic microscopy and infrared (IR) spectroscopy. The former identifies the anatomical parameters of the developing tumor, whilst the latter identifies its biochemical features, both at the micron scale. To implement this diagnostic method, an animal model that mimics human melanoma was developed. The results of this investigation show that using high-frequency (>20 MHz) acoustic microscopy in conjunction with spectroscopic images provides useful information about distinct features of melanoma tumors’ 3D structures. The structures and cytoarchitecture of the tumors were assessed using conventional histology, and their malignant nature was confirmed using histological and immumohistochemical analysis. The proposed approach may provide an invaluable tool in diagnostic dermatology, as it is noninvasive and produces highly detailed and accurate data about the early appearance and development of melanoma tumors.
Keywords: acoustic microscopy; infrared spectroscopy; spectroscopic mapping imaging; microtomography; melanoma early detection; noninvasive examination acoustic microscopy; infrared spectroscopy; spectroscopic mapping imaging; microtomography; melanoma early detection; noninvasive examination

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MDPI and ACS Style

Karagiannis, G.t.; Grivas, I.; Tsingotjidou, A.; Apostolidis, G.; Tsardaka, E.; Dori, I.; Poulatsidou, K.-N.; Tsougos, I.; Wesarg, S.; Doumas, A.; et al. Diagnostic System for Early In Situ Melanoma Detection Using Acoustic Microscopy and Infrared Spectroscopic Mapping Imaging. Cancers 2025, 17, 2599. https://doi.org/10.3390/cancers17152599

AMA Style

Karagiannis Gt, Grivas I, Tsingotjidou A, Apostolidis G, Tsardaka E, Dori I, Poulatsidou K-N, Tsougos I, Wesarg S, Doumas A, et al. Diagnostic System for Early In Situ Melanoma Detection Using Acoustic Microscopy and Infrared Spectroscopic Mapping Imaging. Cancers. 2025; 17(15):2599. https://doi.org/10.3390/cancers17152599

Chicago/Turabian Style

Karagiannis, Georgios th, Ioannis Grivas, Anastasia Tsingotjidou, Georgios Apostolidis, Eirini Tsardaka, Ioanna Dori, Kyriaki-Nefeli Poulatsidou, Ioannis Tsougos, Stefan Wesarg, Argyrios Doumas, and et al. 2025. "Diagnostic System for Early In Situ Melanoma Detection Using Acoustic Microscopy and Infrared Spectroscopic Mapping Imaging" Cancers 17, no. 15: 2599. https://doi.org/10.3390/cancers17152599

APA Style

Karagiannis, G. t., Grivas, I., Tsingotjidou, A., Apostolidis, G., Tsardaka, E., Dori, I., Poulatsidou, K.-N., Tsougos, I., Wesarg, S., Doumas, A., & Georgoulias, P. (2025). Diagnostic System for Early In Situ Melanoma Detection Using Acoustic Microscopy and Infrared Spectroscopic Mapping Imaging. Cancers, 17(15), 2599. https://doi.org/10.3390/cancers17152599

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