The Role of cMET in Gastric Cancer—A Review of the Literature
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
3. Results
3.1. General Background and Preclinical Data on cMET in Gastric Cancer
3.1.1. Immunohistochemistry (IHC) and Fluorescence In Situ Hybridization (FISH)
3.1.2. Next-Generation Sequencing (NGS)/Comprehensive Genomic Profiling (CGP)
3.2. Clinical Exposure of cMET-Driven Therapies in Gastric Cancer
3.2.1. Monoclonal Antibodies
3.2.2. Tyrosine Kinase Inhibitors
4. Discussion
5. Conclusions
Author Contributions
Funding
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Type | Target | Name | Mechanism of Action | Trial (Ref.) | Phase | N° of Patients Included | Inclusion Diagnostic Marker | Effect |
---|---|---|---|---|---|---|---|---|
Monoclonal antibody | HGF | mFolfox + Rilotumumab | Blocks HGF | Rilomet I [19] | III | 608 | IHC ≥ 1 ≤ | No benefit of mAb |
mFolfox + Rilotumumab or EGFRi | MEGA [21] | III | 162 | IHC 2+ or 3+ | No benefit of mAb | |||
MET | Onartuzumab + mFolfox | Blocks MET | METGastric [22] | III | 562 | none | No benefit of mAb | |
HGF and MET | Emibetuzumab | Blocks HGF binding and internalization of MET | NA [23] | II | 15 | IHC 2+ or 3+ | No patients with PR | |
Tyrosine kinase inhibitor | Crizotinib | Multi TKI | AcSé Crizotinib Program [25] | II | 9 | IHC 2+ or 3+ | ORR 33% | |
Foretinib | NA [27] | II | 74 | None | No PR, 15 patiënts SD | |||
Capmatinib | Selective MET TKI | NA [26] | II | 9 | IHC 2+ or 3+ or Hscore > 150 MET/CEN7 ≥ 2 or MET GCN ≥ 5 | 2 patients with SD | ||
Tivantinib | NA [28] | II | 30 | None | No ORR, 36 DCR | |||
Savolitinib | Viktory Umbrella Trial [30] | II | 20 | Amplification ≥ 10 on NGS | ORR 50% | |||
AMG337 | NA [24] | II | 55 | MET/CEN7 ≥ 2 | ORR 19% |
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Van Herpe, F.; Van Cutsem, E. The Role of cMET in Gastric Cancer—A Review of the Literature. Cancers 2023, 15, 1976. https://doi.org/10.3390/cancers15071976
Van Herpe F, Van Cutsem E. The Role of cMET in Gastric Cancer—A Review of the Literature. Cancers. 2023; 15(7):1976. https://doi.org/10.3390/cancers15071976
Chicago/Turabian StyleVan Herpe, Filip, and Eric Van Cutsem. 2023. "The Role of cMET in Gastric Cancer—A Review of the Literature" Cancers 15, no. 7: 1976. https://doi.org/10.3390/cancers15071976
APA StyleVan Herpe, F., & Van Cutsem, E. (2023). The Role of cMET in Gastric Cancer—A Review of the Literature. Cancers, 15(7), 1976. https://doi.org/10.3390/cancers15071976