CDK4/6 Inhibitors Overcome Endocrine ESR1 Mutation-Related Resistance in Metastatic Breast Cancer Patients
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Patients and Data Collection
2.2. Circulating Free DNA Extraction and ESR1 Mutational Analysis
2.3. Statistical Analysis
3. Results
3.1. Patient Characteristics
3.2. ESR1 Mutation Is an Independent Predictive Biomarker of Clinical Recurrence after Adjuvant Therapy
3.3. CDK4/6i Overcomes Hormone Therapy Resistance in ESR1 Mutant Patients
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Characteristics | Patients (n = 42) |
---|---|
Age at diagnosis, median (range) | 55.1 ± 11.3 |
Stage at diagnosis, n (%) I II III IV (i.e., de novo M1) | 14 (33.3%) 11 (26.2%) 6 (14.3%) 11 (26.2%) |
ECOG PS, n (%) 0 1 | 38 (90.5%) 4 (9.5%) |
Pre/Post-menopause, n (%) Pre-menopause Post-menopause | 6 (14.3%) 36 (85.7%) |
HR receptor status in primitive lesions, n (%) ER+/PR+ ER+/PR− | 37 (88.1%) 5 (11.9%) |
Ki67 % in primitive lesions, n (%) <14%, n (%) 14–20%, n (%) >20%, n (%) | 17 (40.5%) 8 (19%) 17 (40.5%) |
Previous CT in neoadjuvant setting, n (%) No Yes | 36 (85.7%) 6 (14.3%) |
Previous CT in adjuvant setting, n (%) No Yes | 24 (57.1%) 18 (42.9%) |
Previous HT in adjuvant setting, n (%) No Yes | 14 (33.3%) 28 (66.7%) |
Previous RT in adjuvant setting, n (%) No Yes | 20 (47.6%) 22 (52.4%) |
Number of metastatic sites, n (%) ≤2 >2 | 28 (66.7%) 14 (33.3%) |
Disease site, n (%) Visceral Bone-only Nodes | 22 (52.4%) 6 (14.3%) 14 (33.3%) |
Endocrine-sensitive or resistant disease, n (%) Sensitive Resistant | 29 (69%) 13 (31%) |
CDK4/6i therapy, n (%) Palbociclib Ribociclib Abemaciclib | 15 (35.7%) 20 (47.6%) 7 (16.7%) |
CDK4/6i line of therapy, n (%) 1 2 | 35 (83.3%) 7 (16.7%) |
Type of HT associated to CDK4/6i, n (%) Letrozole Fulvestrant | 25 (59.5%) 17 (40.5%) |
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Crucitta, S.; Ruglioni, M.; Lorenzini, G.; Bargagna, I.; Luculli, G.I.; Albanese, I.; Bilancio, D.; Patanè, F.; Fontana, A.; Danesi, R.; et al. CDK4/6 Inhibitors Overcome Endocrine ESR1 Mutation-Related Resistance in Metastatic Breast Cancer Patients. Cancers 2023, 15, 1306. https://doi.org/10.3390/cancers15041306
Crucitta S, Ruglioni M, Lorenzini G, Bargagna I, Luculli GI, Albanese I, Bilancio D, Patanè F, Fontana A, Danesi R, et al. CDK4/6 Inhibitors Overcome Endocrine ESR1 Mutation-Related Resistance in Metastatic Breast Cancer Patients. Cancers. 2023; 15(4):1306. https://doi.org/10.3390/cancers15041306
Chicago/Turabian StyleCrucitta, Stefania, Martina Ruglioni, Giulia Lorenzini, Irene Bargagna, Giovanna Irene Luculli, Irene Albanese, Diana Bilancio, Francesca Patanè, Andrea Fontana, Romano Danesi, and et al. 2023. "CDK4/6 Inhibitors Overcome Endocrine ESR1 Mutation-Related Resistance in Metastatic Breast Cancer Patients" Cancers 15, no. 4: 1306. https://doi.org/10.3390/cancers15041306