HDAC8 Deacetylates HIF-1α and Enhances Its Protein Stability to Promote Tumor Growth and Migration in Melanoma
Round 1
Reviewer 1 Report
The manuscript entitled “HDAC8 deacetylates HIF-1α and enhances its protein stability to promote tumor growth and migration in melanoma” . The experimental design is rigorous and reliable, data presented in the manuscript are comprehensive and agreeable.
Author Response
We thank you for reviewing our manuscript thoroughly.
Reviewer 2 Report
Authors have given concise and clear report on role of Hdac8 on HIF1alpha. HDACs are great candidate for supportive/ combinational therapies, therefore It would be great if authors can provide the in vivo results that can strengthen the hypothesis.
Thank you
Author Response
We thank you for reviewing our manuscript thoroughly. We agree that in vivo study would further improve our manuscript. However, we are planning to extend our study using mouse models in future study and related research.
