Multiple Laparoscopic Liver Resection for Colorectal Liver Metastases
Abstract
:Simple Summary
Abstract
1. Introduction
2. Feasibility of Multiple Concomitant LLR
3. Ultrasonography and Other Operative Guidance in Multiple LLR for CRLM
4. Postoperative Short-Term Outcomes after Multiple LLR
5. Oncological Outcomes after Multiple LLR for CRLM
6. Two-Stage Laparoscopic Hepatectomy
7. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Variable | Number of Patients Reported [20,21,22,23] | ||||
---|---|---|---|---|---|
Number of LLR | |||||
2 | 178 (65.7%) | ||||
3–4 | 69 (25.5%) | ||||
≥5 | 24 (8.9%) | ||||
Variable | Number of Patients Reported | Kazaryan et al. [20] (n = 104) | D’Hondt et al. [21] (n = 36) | Nassar et al. [22] (n = 39) | Aghayan et al. [23] (n = 92) |
Type of LLR | Not described | ||||
Left lateral sectionectomy with right atypical | 29 | 20 | 9 | ||
Left hemihepatectomy with right atypical | 1 | 1 | |||
Multiple atypical resections | 126 | 83 | 23 | 20 | |
Left | 13/126 (10.3%) | 6 | 7 | ||
Right | 36/126 (28.6%) | 22 | 14 | ||
Bilateral | 77/126 (61.1%) | 54 | 23 | ||
Right bi-segmentectomy or hemihepatectomy with left atypical | 5 | 1 | 4 |
Article | Tumor Maximum Size (mm) | p (vs. Single) | Mean Blood Loss (mL Range) | p (vs. Single) | Mean Operative Time (min (Range) | p (vs. Single) | Conversion Rate | p (vs. Single) |
---|---|---|---|---|---|---|---|---|
Karazyan et al. [20] (n = 104) | 22 | 0.12 | 300 (50–5000) | 0.75 | 186 (75–390) | 0.26 | 2.9% | 0.41 |
D’Hondt et al. [21] (n = 36) | Not described | 250 (150–450) | <0.001, higher for multiple | 200 (170–230) | <0.001, longer for multiple | 8.3% | 0.07 | |
Nassar et al. [22] (n = 39) | 23.9 | 0.69 | 188.9 (0–1000) | 0.39 | 217.3 (90–369) | 0.039, longer for multiple | 0% | 0.88 |
Technique | Location of Tumors Detected | Tumor Margins | Detection of Missing Tumors from Preoperative CT Scan | Availability in OR | Disadvantages |
---|---|---|---|---|---|
Intraoperative ultrasound | Superficial or deep | Location relative to veins | Yes | Available | Technicality |
Indocyanine green fluorescence | Only superficial | Real-time visualization | Yes, if superficial | Available | No deep lesion visualization |
3D models | Superficial and deep | Location relative to anatomical structures | No | Not available | Location of tumor detected only if by preoperative CT-scan |
Article | 90-Days Morbidity Rate | p (vs. Single) | Major Complication (Clavien III–IV) | p (vs. Single) | 90-Days Mortality Rate (n) | p (vs. Single) | Length of Stay (Days) | p (vs. Single) | 5-Year OS | p (vs. Single) | 5-Year RFS | p (vs. Single) |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Karazyan et al. [20] (n = 104) | 20 (19.2%) | 0.17 | 14 (13.4%) | Not described | 1 (0.96%) | 3 (1–26) | 0.62 | 42% | 0.62 | 16% | 0.14 | |
D’Hondt et al. [21] (n = 36) | 2 (5.6%) | 1.0 | 1 (2.8%) | 1.0 | 0 (0%) | 1.0 | 5 (4–7) | 0.015, longer for multiple | 66% | 0.49 | 28% | 0.62 |
Nassar et al. [22] (n = 39) | 14 (27.5%) | 0.82 | 1 (1.9%) | 0.45 | 0 (0%) | 0.94 | 5.5 | 0.59 | Not described | Not described |
Article | 1st Stage Laparoscopy | 2nd Stage Laparoscopy | Interval Time (Months) | Mean Number of CRLM | Conversion Rate 1st/2nd | 90-Day Morbidity Rate 1st/2nd |
---|---|---|---|---|---|---|
Fuks et al. [42] | 34 | 26 | 3 | 2/4 | ||
Okumura et al. [43] | 38 | 38 | 2.8 | 6 | 1/4 | 16%/26% |
Kilburn et al. [44] | 7 | 1 | 3.4 | 5.2 | 0/1 | 0%/0% |
Taillieu et al. [45] | 23 | 7 | 1.9 | Not described | 1/1 | 0%/14% |
Di Fabio et al. [46] | 8 | 3 | 2.9 | 4 | 0/1 | 0%/Not described |
Görgec et al. [47] | Not described | 12 | Not described | 3.6 | -/2 | Not described/17% |
Levi Sandri et al. [48] | 5 | 0 | 2.2 | 6.6 | 0/- | Not described |
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Share and Cite
Nassar, A.; Tzedakis, S.; Dhote, A.; Strigalev, M.; Coriat, R.; Karoui, M.; Dohan, A.; Gaillard, M.; Marchese, U.; Fuks, D. Multiple Laparoscopic Liver Resection for Colorectal Liver Metastases. Cancers 2023, 15, 435. https://doi.org/10.3390/cancers15020435
Nassar A, Tzedakis S, Dhote A, Strigalev M, Coriat R, Karoui M, Dohan A, Gaillard M, Marchese U, Fuks D. Multiple Laparoscopic Liver Resection for Colorectal Liver Metastases. Cancers. 2023; 15(2):435. https://doi.org/10.3390/cancers15020435
Chicago/Turabian StyleNassar, Alexandra, Stylianos Tzedakis, Alix Dhote, Marie Strigalev, Romain Coriat, Mehdi Karoui, Anthony Dohan, Martin Gaillard, Ugo Marchese, and David Fuks. 2023. "Multiple Laparoscopic Liver Resection for Colorectal Liver Metastases" Cancers 15, no. 2: 435. https://doi.org/10.3390/cancers15020435
APA StyleNassar, A., Tzedakis, S., Dhote, A., Strigalev, M., Coriat, R., Karoui, M., Dohan, A., Gaillard, M., Marchese, U., & Fuks, D. (2023). Multiple Laparoscopic Liver Resection for Colorectal Liver Metastases. Cancers, 15(2), 435. https://doi.org/10.3390/cancers15020435