Surgical Treatment of Carcinomas of the Oral Minor Salivary Glands—Oncological Outcome in Dependence of Tumor Entity and Therapeutic Strategies
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Patient Collective and Obtained Data
2.2. Statistics
3. Results
3.1. Patient Cohort
3.2. Tumor Stage and Cervical Metastases
3.3. Therapeutic Procedures
3.4. Disease Recurrence and Survival
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Parameter | Number of Cases (%) |
---|---|
Gender | |
Female | 41 (50.6) |
Male | 40 (49.4) |
Age | |
<20 years | 2 (2.5) |
21–40 years | 13 (16) |
41–60 years | 31 (42) |
61–80 years | 29 (35.8) |
>81 years | 3 (3.7) |
Tumor Localizations | |
Hard palate | 48 (59.3) |
Soft palate | 6 (7.4) |
Mandible | 11 (13.6) |
Planum buccale | 11 (13.6) |
Tongue | 2 (2.5) |
Lip | 3 (3.6) |
Tumor Entities | |
Adenoid cystic carcinoma (ACC) | 43 (53.1%) |
Adenocarcinoma not otherwise specified (AC-NOS) | 14 (17.3%) |
Mucoepidermoid Carcinoma (MEC) | 24 (29.6%) |
ACC | AC-NOS | MEC | p-Value | |
---|---|---|---|---|
Mean patient age (years) | 54.7 ± 14.8 | 64.4 ± 12.8 | 49.8 ± 17.3 | 0.02 |
Gender | ||||
Male | 21 (52.5%) | 8 (20%) | 11 (27.5%) | 0.79 |
Female | 22 (53.7%) | 6 (14.6%) | 13 (31.7%) | |
Pathological tumor stage (T) | ||||
T1 | 5 (11.6%) | 5 (35.7%) | 14 (58.4%) | 0.002 |
T2 | 5 (11.6%) | 4 (28.6%) | 2 (8.3%) | |
T3 | 8 (18.6%) | 1 (7.1%) | 2 (8.3%) | |
T4 | 25 (58.2%) | 4 (28.6%) | 6 (25%) | |
Grading (G) | ||||
G1 | 0 | 8 (72.7%) | 16 (84.2%) | <0.001 |
G2 | 12 (80%) | 2 (18.2%) | 2 (10.5%) | |
G3 | 3 (20%) | 1 (9.1%) | 1 (5.3%) | |
Neck node metastases (N) | ||||
N0 | 22 (61.1%) | 10 (90.9%) | 9 (75%) | 0.154 |
N+ | 14 (38.9%) | 1 (9.1%) | 3 (25%) | |
Resection status (R) | ||||
R0 | 10 (23.3%) | 9 (64.3%) | 21 (87.5%) | <0.001 |
R + (R1/2/X) | 33 (76.7%) | 5 (35.7%) | 3 (12.5%) | |
Perineural invasion (PN) | ||||
PN0 | 13 (31.7%) | 9 (64.3%) | 19 (86.4%) | <0.001 |
PN1 | 28 (68.3%) | 5 (35.7%) | 3 (13.6%) | |
Lymphatic invasion (L) | ||||
L0 | 32 (76.2%) | 13 (92.9%) | 22 (95.7%) | 0.073 |
L1 | 10 (23.8%) | 1 (7.1%) | 1 (4.3%) | |
Vascular invasion (V) | ||||
V0 | 38 (90.5%) | 13 (92.9%) | 22 (95.7%) | 0.751 |
V1 | 4 (9.5%) | 1 (7.1%) | 1 (4.3%) | |
Adjuvant radiotherapy (RT) | ||||
No adjuvant RT | 8 (18.6%) | 10 (71.4%) | 20 (83.3%) | <0.001 |
Adjuvant RT | 35 (81.4%) | 4 (28.6%) | 4 (16.7%) |
ACC | AC-NOS | MEC | p-Value | |
---|---|---|---|---|
Disease recurrence | 17 (77.3%) | 3 (13.6%) | 2 (9.1%) | 0.02 |
Type of disease recurrence | ||||
Local recurrence | 8 (80%) | 2 (20%) | 0 | |
Distant metastases | 4 (57.1%) | 1 (14.3%) | 2 (28.6%) |
Hazard Ratio (95-CI) | p-Value | |
---|---|---|
T Stage | 3.1 (0.9–10.1) | 0.067 |
N0/N+ | 14 (1.7–114.1) | 0.014 |
Tumor entity | 1.3 (0.5–3.5) | 0.564 |
Differentiation grade | 1.6 (0.3–8.0) | 0.558 |
Patient age | 1.1 (1.0–1.1) | 0.098 |
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Moratin, J.; Horn, D.; Semmelmayer, K.; Ristow, O.; Engel, M.; Hoffmann, J.; Bleymehl, M.; Held, T.; Zittel, S.; Freudlsperger, C. Surgical Treatment of Carcinomas of the Oral Minor Salivary Glands—Oncological Outcome in Dependence of Tumor Entity and Therapeutic Strategies. Cancers 2023, 15, 3895. https://doi.org/10.3390/cancers15153895
Moratin J, Horn D, Semmelmayer K, Ristow O, Engel M, Hoffmann J, Bleymehl M, Held T, Zittel S, Freudlsperger C. Surgical Treatment of Carcinomas of the Oral Minor Salivary Glands—Oncological Outcome in Dependence of Tumor Entity and Therapeutic Strategies. Cancers. 2023; 15(15):3895. https://doi.org/10.3390/cancers15153895
Chicago/Turabian StyleMoratin, Julius, Dominik Horn, Karl Semmelmayer, Oliver Ristow, Michael Engel, Jürgen Hoffmann, Moritz Bleymehl, Thomas Held, Sven Zittel, and Christian Freudlsperger. 2023. "Surgical Treatment of Carcinomas of the Oral Minor Salivary Glands—Oncological Outcome in Dependence of Tumor Entity and Therapeutic Strategies" Cancers 15, no. 15: 3895. https://doi.org/10.3390/cancers15153895