Management of Primary Uterine Cervix B-Cell Lymphoma Stage IE and Fertility Sparing Outcome: A Systematic Review of the Literature
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
3. Results
4. Discussion
4.1. Symptoms and Diagnosis
4.2. Therapy
4.3. Fertility Sparing Treatment
4.4. Pregnancy Outcome after Treatment
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Appendix A. JBI Checklist for Case Report and Case Series
D1. | Were patient’s demographic characteristics clearly described? |
D2. | Was the patient’s history clearly described and presented as a timeline? |
D3. | Was the current clinical condition of the patient on presentation clearly described? |
D4. | Were diagnostic tests or assessment methods and the results clearly described? |
D5. | Was the intervention(s) or treatment procedure(s) clearly described? |
D6. | Was the post-intervention clinical condition clearly described? |
D7. | Were adverse events (harms) or unanticipated events identified and described? |
D8. | Does the case report provide takeaway lessons? |
D1. | Were there clear criteria for inclusion in the case series? |
D2. | Was the condition measured in a standard, reliable way for all participants included in the case series? |
D3. | Were valid methods used for identification of the condition for all participants included in the case series? |
D4. | Did the case series have consecutive inclusion of participants? |
D5. | Did the case series have complete inclusion of participants? |
D6. | Was there clear reporting of the demographics of the participants in the study? |
D7. | Was there clear reporting of clinical information of the participants? |
D8. | Were the outcomes or follow up results of cases clearly reported? |
D9. | Was there clear reporting of the presenting site(s)/clinic(s) demographic information? |
D10. | Was statistical analysis appropriate? |
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Author, Year | D1 | D2 | D3 | D4 | D5 | D6 | D7 | D8 |
---|---|---|---|---|---|---|---|---|
Stabile et al., 2022 [27] | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
Quaresima et al., 2022 [28] | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
Capsa et al., 2022 [29] | Yes | Yes | Yes | Yes | Yes | Yes | Unclear | Yes |
Akkour et al., 2021 [30] | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
Gui et al., 2019 [31] | Yes | Yes | Unclear | Yes | Yes | Yes | Unclear | Yes |
Boussios et al., 2018 [32] | Unclear | No | Unclear | No | Yes | No | Unclear | Yes |
Roberts et al., 2018 [33] | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
Cubo et al., 2017 [34] | Yes | Yes | Yes | Yes | Yes | Yes | Unclear | Yes |
Fratoni et al., 2016 [35] | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
Posfai et al., 2015 [36] | Yes | Unclear | Yes | Yes | Yes | Unclear | Unclear | Yes |
Mouhajir et al., 2014 [37] | Yes | No | Yes | Unclear | Yes | Yes | No | Yes |
Binesh et al., 2012 [38] | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
Parnis et al., 2012 [39] | Yes | Yes | Yes | Yes | Yes | Yes | Unclear | Yes |
Vasudev et al., 2012 [40] | Yes | No | Yes | Yes | Yes | Yes | Unclear | Yes |
Parva et al., 2011 [41] | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
Upanal et al., 2011 [42] | Yes | No | Yes | Yes | Yes | Yes | Unclear | Yes |
Baijal et al., 2009 [3] | Yes | No | Yes | Unclear | Yes | Yes | Unclear | No |
Ab Hamid et al., 2008 [7] | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
Ferreri et al., 2008 [43] | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
Wuntakal et al., 2008 [44] | Yes | Unclear | Yes | Yes | Yes | Yes | Unclear | Yes |
Lorusso et al., 2007 [45] | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
Semczuk et al., 2006 [46] | Yes | Yes | Yes | Yes | Yes | Yes | Unclear | Yes |
Gonzalez-Cejudo et al., 2006 [47] | Unclear | No | Unclear | No | Yes | No | Unclear | Unclear |
Dursun et al., 2005 [48] | Yes | No | Yes | Yes | Yes | Yes | Unclear | Yes |
Chandy et al., 1998 [49] | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
Nasu et al., 1998 [50] | Yes | No | Unclear | No | Yes | No | Unclear | Unclear |
Author, Year | D1 | D2 | D3 | D4 | D5 | D6 | D7 | D8 | D9 | D10 |
---|---|---|---|---|---|---|---|---|---|---|
Goda et al., 2020 [18] | Yes | Yes | Unclear | Unclear | Yes | Yes | Yes | Yes | Yes | Unclear |
Cao et al., 2014 [51] | Yes | Yes | Unclear | Unclear | Yes | Yes | Yes | Yes | Yes | Unclear |
Signorelli et al., 2007 [52] | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Unclear |
Hariprasad et al., 2006 [53] | Yes | Yes | Unclear | No | Yes | Yes | Yes | Yes | Yes | Unclear |
Chan et al., 2005 [19] | Yes | Yes | Unclear | No | Yes | Yes | Yes | Yes | Yes | Unclear |
Lee et al., 1998 [54] | Yes | Yes | Unclear | No | Yes | Yes | Yes | Yes | Yes | Unclear |
Makarewicz et al., 1995 [55] | Yes | Yes | Unclear | No | Yes | Yes | Yes | Yes | Yes | Unclear |
Stroh et al., 1995 [8] | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Unclear |
Age | Menopause | Presence of “B” Symptoms | DLBCL Subtype | Immuno-Phenotype | Macroscopic Appearance /Dimension | PAP Smear | Diagnosis | Treatment | Outcome/Follow-Up (Months) | Reference |
---|---|---|---|---|---|---|---|---|---|---|
83 | Yes | No | GCB | Cervical mass/4 cm | - | Surgical specimen | Hysteroscopic resection + RT () | DF/ | Stabile et al., 2022 [28] | |
30 | No | No | - | CD20+, CD10+, BCL6+, PAX5+ | Cervical mass/5 cm | Normal | Hysteroscopi c biopsy and D&C | CT (R-CHOP ×8) + ovarian suppression | DF/- | Quaresima et al., 2022 [56] |
75 | Yes | No | - | CD20+, CD10-, CD23-, CD3-, CD5-, Ki 67 50% | Cervical mass extended to upper vagina/4 cm | - | Biopsy | CT (CHOP) + RT (45 Gy) | DF/29 | Capsa et al., 2022 [30] |
54 | Yes | No | ABC | CD45+, CD20+, BCL2+, MUM1+, BCL6+ | Exophytic mass /9 × 8 × 8 cm | Normal | Biopsy | Surgery (radical trachelectomy in patient with previous subtotal hysterectomy + BSO) + CT (R- CHOP ×6 + RT (20 Gy) | DF/24 | Akkour et al., 2021 [31] |
52 | Yes | No | GCB | CD20+ CD10+B CL-6- | Cervical mass/6 cm | - | Biopsy | CT (R-CHOP ×6) + RT (45Gy) | DF/18 | Goda et al., 2020 [20] |
50 | Yes | No | GCB | CD20+ CD10+ BCL-6- | Cervical mass/3 cm | - | Biopsy | CT (R-CHOP ×6) + RT (45Gy) | DF/43 | |
39 | No | No | ABC | CD20+ CD10- BCL-6- | Bulky cervical mass extending to upper third of vagina and lower uterine segment/8 cm | - | Biopsy | CT (R-CHOP ×6) + RT (45Gy) | DF/8 | |
36 | No | No | - | LCA+ CD20+ | Cervical mass/4 cm | - | Biopsy | CT (CHOP ×6) | DF/73 | Gui et al., 2019 [32] |
60 | Yes | No | - | - | - | - | - | CT (R-CHOP ×6) + RT | DF/- | Boussios et al., 2018 [33] |
55 | Yes | No | - | - | Bulky endocervical mass/10 cm | - | Biopsy, D&C | CT (R-CHOP ×3) + LAVH | DF/36 | Roberts et al., 2018 [34] |
51 | Yes | No | GCB | CD20+, CD5+, BCL2+, BCL6+, CD45, CD23, CD43, CD10- , EBER-, Cyclin D1- | Bulky exophytic cervical mass/10 cm | Normal | Biopsy | CT (R-CHOP ×6) | DF/24 | Cubo et al.2017 [35] |
39 | No | No | Spindle cell or sarcomatoi d variant, GCB | LCA+, CD20+, CD45+, BCL6+, | Bulky endocervical mass/- | - | Biopsy | Surgery (TH) + CT (R- CHOP ×3) | DF/48 | Fratoni et al., 2016 [36] |
27 | No | No | ABC | CD20+ MUM1+ | Mass between uterus and bladder/6.5 × 2.3 cm | LSIL HPV - | LLETZ | CT (R-CHOP ×6) | DF/49 | Posfai et al., 2015 [51] |
20 | No | No | - | - | - | - | Biopsy | CT (CHOP ×7) | DF/84 | Cao et 2014 [37] al. |
58 | Yes | No | - | - | Bulky mass/- | - | Biopsy | CT (CHOP x6) + RT | CR + CNS relapse/47 alive/56 | |
49 | No | No | - | CD20+ CD45+ | Bulky exophitic cervical mass/ | - | Biopsy | CT (CHOP ×6) + RT (46Gy) | DF/192 | Mouhajir et al., 2014 [38] |
85 | Yes | No | - | CD20+ | Bulky, exophytic cervical mass/7 × 4 cm | - | Biopsy | CT (R-CHOP ×3) | PR, refused other treatments /5 | Binesh et al., 2012 [39] |
54 | Yes | No | - | LCA+ CD20+ BCL2 - | Friable cervical mass extending to low uterine segment/- | - | Biopsy | CT (R-CHOP ×6) + RT (35Gy) | DF/17 | Parnis et al., 2012 [40] |
52 | Yes | No | - | CD20+ CD45+ CD3- | endocervical polyp /5 × 3 cm | Normal | Surgical specimen | Surgery (TH BSO) | DF/20 | Vasudev et al., 2012 [41] |
21 | No | No | - | LCA+ CD45+ CD20+ CD79A+ | Enlarged cervix/- | Normal | Biopsy | CT (R-CHOP ×6) + previous cryopreservation of embryos + ovarian suppression | DF/72 | Parva et al., 2011 [42] |
49 | - | No | - | CD20+ | Enlarged cervix/8 × 4.5 × 6 cm | - | Biopsy | CT (R-CHOP ×6) + RT (30 Gy) | DF/20 | Upanal et al., 2011 [43] |
44 | No | No | - | LCA+, CD20+ | Cervical mass/7 × 7 cm | - | Biopsy | CT (R-CHOP ×3) + RT (46Gy) | DF/15 | Baijal et al., 2009 [5] |
43 | No | No | - | L26/CD20+ | Bulky exophytic cervical mass/5 × 7.8 × 3 cm | Normal | Biopsy | CT (CHOP ×6) | DF/- | Ab Hamid et al., 2008 [9] |
29 | No | No | - | CD20+ CD79a+ BCL6+ CD30- CD3- CD10- | Cervical mass infiltrating upper vagina/3 cm | Normal | Biopsy | Ovarian transposition + CT (CHOP ×6) + RT (30Gy) | DF/54 | Ferreri et al., 2008 [44] |
60 | Yes | No | - | CD20+ CD3+ CD5+ CD21+ CD23+ P53+ MUM1+ | Cervical mass extending to upper vagina and left parametrium, bilateral hydronephrosis/7 cm | - | Biopsy | CT (CHOP ×6) | DF/- | Wuntakal et al., 2008 [45] |
29 | No | No | - | CD20+ LCA+ CD30- CD45- | Bulky cervical mass extending to upper vagina/5 cm | Normal | Biopsy | CT (CHOP ×3) + surgery (cold-knife conization) + CT (CHOP ×3) | DF/48 | Lorusso et al., 2007 [52] |
32 | No | - | - | - | - | - | - | CT (CHOP ×6) | DF/91 | Signorelli et al., 2007 [53] |
45 | - | - | - | - | Cervical mass/6 × 5 cm | - | - | CT (CHOP ×6) + surgery (TH + BSO + pelvic nodal sampling) | DF/38 | |
58 | - | - | - | - | Cervical mass/2 × 1 cm | - | - | Surgery (TH + BSO) + CT (CHOP ×4) | DF/228 | |
54 | - | - | - | - | - | - | - | Surgery (TH + BSO) | DF/118 | |
47 | No | No | - | LCA+ CD20+ | Cervical mass extending to parametrium bilaterally, uterus, upper vagina and with bilateral vesicoureteral junction obstruction/- | - | Biopsy | CT (CHOP ×3 + COP ×3 with Adriamicin omitted because of cardiotoxicity ) + RT (45Gy) | DF/13 | Hariprasad et al., 2006 [46] |
80 | Yes | No | - | - | Necrotic, bleeding cervical growth extending to upper vagina, left parametrium and uterus/- | - | Biopsy | CT (CHOP ×6), RT omitted because of old age | DF/12 | |
43 | Yes | - | - | CD20+ CD45+ BCL6+ BCL2- CD30- CD3- | Bulky cervical mass mimicking leiomyoma/10 cm | Normal | Surgical specimen | Surgery (TH) + CT (CHOP ×6) | DF/10 | Semczuk et al. 2006 [47] |
26 | No | No | - | CD20+ CD3+ CD30+ | Cervical mass/6.5 cm | - | Surgical specimen | Surgery (TH) + CT (R- CHOP) | DF/12 | Gonzalez- Cejudo et al., 2006 [48] |
51 | - | No | - | LCA+, CD20+ | Cervical mass/4 cm | HSIL | LEEP | Surgery (TH + BSO + pelvic and paraaortic LMP) + CT (CHOP ×6) | DF/19 | Dursun et al., 2005 [54] |
76 | Yes | No | - | - | Cervical mass/3 cm | ASCUS | Biopsy | Surgery (TH + BSO + pelvic limphadenect | DF/14 | Chan et al., 2005 [21] |
67 | Yes | No | - | - | Cervical polyp | - | Biopsy (polypectom y) | Surgery (TH + BSO + pelvic nodes dissection) + RT (44 Gy) | DF/120 | Lee et al., 1998 [49] |
65 | Yes | No | - | - | Bulky exophytic cervical mass/- | - | Biopsy | Surgery (TH + BSO + pelvic nodes dissection) + RT (44 Gy) | DF/120 | |
50 | Yes | No | - | CD45+ | Firm multiple nodules involving cervix and upper vagina/10 cm | - | Biopsy | CT (CHOP ×4) + RT (46Gy) + CT (CHOP ×2) | DF/17 | Chandy et al., 1998 [50] |
64 | Yes | No | - | LCA+ L26+ MB1+ | Hards cervical mass/10 cm | - | Biopsy | CT (THP- COP x10) | DF/18 | Nasu et al., 1998 [55] |
37 | No | No | Centroblast ic (Kiel classificati on) | - | Exophitic cervical mass extending to upper vagina and left parametrium | - | - | CT (cyclophospham ide, vincristine, prednisone ×3) + RT (45Gy) | DF/96 | Makarewicz et al., 1995 [57] |
33 | No | No | Centroblast ic centrocytic | - | Cervical mass extending to upper third of vagina/- | Normal 1 year before | Surgical specimen | Surgery (TH+BSO+pelvi c limph node dissection) | Relapse after 6 months with a 6 cm tumour of upper vagina treated with CT (CHOP ×6), after it DF/42 | |
53 | Yes | No | - | - | Cervical mass extending to upper vagina/ 4 × 10 cm | - | Biopsy | CT (CHOP + bleomycin) + RT (40 Gy) + CT (as previously) | DF/173 | Stroh et al 1995 [10] |
64 | Yes | No | - | - | Cervical mass/8 Cm | - | Biopsy | RT (60 Gy) + CT (CHOP + bleomycin) + RT + CT | DF/165 | |
66 | Yes | No | - | - | Cervical mass/3 Cm | - | Biopsy | CT (CHOP) + RT (40 Gy) + CT | DF/60 | |
67 | Yes | No | - | - | Cervical mass/- | - | Biopsy | CT (ASAP, MBACOS, MINE) + RT (40 Gy) | PR/18 |
Reference | Age | Treatment | Timing Post-Treatment | Mode of Delivery | Complications |
---|---|---|---|---|---|
Quaresima et al., 2022 [29] | 30 | CHOP + Rituximab + ovarian suppression (Leuprolide) | 1 year | Induction of labour at 41 gw—Vaginal delivery | None |
Posfai et al., 2015 [37] | 27 | CHOP + Rituximab | 14 months | - | Miscarriage 8th gw |
Parva et al., 2011 [43] | 21 | CHOP + Rituximab | 5.5 years | Vaginal delivery | None |
Ferreri et al., 2008 [44] | 29 | CHOP + Rituximab + (ovarian transposition) + RT | 3 years | Vaginal delivery | None |
Lorusso et al., 2007 [52] | 29 | CHOP + cold knife conization | 3 years | Planned CS at 38 gw | None |
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Stabile, G.; Ripepi, C.; Sancin, L.; Restaino, S.; Mangino, F.P.; Nappi, L.; Ricci, G. Management of Primary Uterine Cervix B-Cell Lymphoma Stage IE and Fertility Sparing Outcome: A Systematic Review of the Literature. Cancers 2023, 15, 3679. https://doi.org/10.3390/cancers15143679
Stabile G, Ripepi C, Sancin L, Restaino S, Mangino FP, Nappi L, Ricci G. Management of Primary Uterine Cervix B-Cell Lymphoma Stage IE and Fertility Sparing Outcome: A Systematic Review of the Literature. Cancers. 2023; 15(14):3679. https://doi.org/10.3390/cancers15143679
Chicago/Turabian StyleStabile, Guglielmo, Chiara Ripepi, Lara Sancin, Stefano Restaino, Francesco Paolo Mangino, Luigi Nappi, and Giuseppe Ricci. 2023. "Management of Primary Uterine Cervix B-Cell Lymphoma Stage IE and Fertility Sparing Outcome: A Systematic Review of the Literature" Cancers 15, no. 14: 3679. https://doi.org/10.3390/cancers15143679