Arising Novel Agents in Lung Cancer: Are Bispecifics and ADCs the New Paradigm?
Abstract
:Simple Summary
Abstract
1. Introduction
2. Bispecific Antibodies
2.1. C-Met Targeting
2.2. HER2/HER3 Targeting
2.3. PD-1/CTLA-4 Targeting
2.4. Small Cell Lung Cancer Targeting
3. Antibody-Drug Conjugates
3.1. HER2 Targeting
3.2. HER3 Targeting
3.3. TROP2 Targeting
3.4. C-Met Targeting
3.5. AXL Targeting
3.6. Emerging ADCs
4. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Drug Name | Trial | NCT |
---|---|---|
Amivantamab | MARIPOSA1/Phase 3 | NCT04487080 |
AZD-9592 | EGRET/Phase 1 | NCT05647122 |
Tarlatamab | DeLLphi-301/Phase 2 | NCT05060016 |
MEDI5752 | Phase 1 | NCT03530397 |
Zenocutuzumab | Phases 1 and 2 | NCT02912949 |
INBRX-105 | Phase 2 | NCT03809624 |
Drug Name | Trial | Target | NCT |
---|---|---|---|
Enapotamab Vedotin | Phase 1 | Axl | NCT02988817 |
Trastuzumab Emtansine | Phase 2 | HER2 | NCT02289833 |
Trastuzumab Deruxtecan | DESTINY-Lung01 | HER2 | NCT03505710 |
Patritumab Deruxtecan | HERTHENA-Lung02 | HER3 | NCT05338970 |
Datopotamab Deruxtecan | TROPION-Lung01 | TROP2 | NCT04656652 |
Teliso-V | Phase 2 | c-Met | NCT03539536 |
Mipasetamab uzoptirine | Phase 1 | Axl | NCT05389462 |
Enfortumab Vedotin | Phase 2 | Nectin-4 | NCT04225117 |
Tisotumab Vedotin | InnovaTV 201 | Tissue Factor | NCT02001623 |
Farletuzumab Ecteribulin | Phase 1 | Folate receptor alpha | NCT03386942 |
Cofetuzumab Pelidotin | Phase 1 | PTK7 | NCT02222922 |
Tusamitamab Ravtansine | CARMEN-LC03 | CEACAM5 | NCT04154956 |
Lifastuzumab Vedotin | Phase 1 | NaPi2b | NCT01363947 |
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Reyes, A.; Pharaon, R.; Mohanty, A.; Massarelli, E. Arising Novel Agents in Lung Cancer: Are Bispecifics and ADCs the New Paradigm? Cancers 2023, 15, 3162. https://doi.org/10.3390/cancers15123162
Reyes A, Pharaon R, Mohanty A, Massarelli E. Arising Novel Agents in Lung Cancer: Are Bispecifics and ADCs the New Paradigm? Cancers. 2023; 15(12):3162. https://doi.org/10.3390/cancers15123162
Chicago/Turabian StyleReyes, Amanda, Rebecca Pharaon, Atish Mohanty, and Erminia Massarelli. 2023. "Arising Novel Agents in Lung Cancer: Are Bispecifics and ADCs the New Paradigm?" Cancers 15, no. 12: 3162. https://doi.org/10.3390/cancers15123162