Benefits from Adjuvant Chemotherapy in Patients with Resected Non-Small Cell Lung Cancer: Possibility of Stratification by Gene Amplification of ACTN4 According to Evaluation of Metastatic Ability
Abstract
Simple Summary
Abstract
1. Introduction
2. Adjuvant Chemotherapy in NSCLC
3. Current Biomarker Candidates for Perioperative Patients with NSCLC
4. ACTN4 as a Biomarker for Evaluation of Metastatic Ability
5. Summary of the Advantages and Limitations of Perioperative Biomarkers
6. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Histology | Stage | Adjuvant Chemotherapy | Evaluation Methods | |
---|---|---|---|---|
Miura et al. (2016) [32] | NSCLC | IB-II | CDDP + VNR | mRNA expression |
Shiraishi et al. (2017) [33] | Ad | II-IIIA | CDDP + VNR | Protein expression |
Noro et al. (2021) [34] | Ad | IA/IB | UFT | Gene amplification |
Miyanaga et al. (2013) [75] | HGNT | resected | Not specified | cDNA sequencing |
Noro et al. (2013) [85] | Ad | IA-IB | Not specified | Gene amplification |
Noro et al. (2017) [86] | Sq | I-II | Not specified | Gene expression |
Yamagata et al. (2003) [87] | NSCLC | resected | Not specified | cDNA microarrays |
Biomarker | Function | Advantage | Limitation |
---|---|---|---|
Gene expression signature | Gene combinations for poor prognosis and poor chemotherapeutic response | More accurate prognostication of a signature from multiple genes compared with individual genes alone | Statistical validation and reproducibility of the signatures/Not a predictor for MRD |
ERCC1 | Removal of DNA intrastrand crosslinks by nucleotide excision repair | Predictor for the efficacy of cisplatin | Negative results in randomized phase III clinical trials/Not a predictor for MRD |
TP53 | Prevention and suppression of abnormal cell proliferation through mechanisms including cell cycle arrest, apoptosis, and DNA repair | One of the most frequently mutated genes in lung cancer regardless of histologic type | Not a predictor for MRD |
PD-L1 | Binding to its receptor PD-1 expressed by T cells and other immune cells to regulate immune responses | Predictor for the efficacy of anti-PD-1/PD-L1 antibody | Not a predictor for MRD |
ctDNA | Tumor-derived DNA released in the blood | Possibility of MRD detection | Cost/Not a predictor for the efficacy of the specific chemotherapeutic agents |
ACTN4 | Involvement in cancer invasion and metastatic potential | Evaluating tumor metastatic potential and cancer invasiveness | Not a predictor for the efficacy of specific chemotherapeutic agents |
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Tozuka, T.; Noro, R.; Seike, M.; Honda, K. Benefits from Adjuvant Chemotherapy in Patients with Resected Non-Small Cell Lung Cancer: Possibility of Stratification by Gene Amplification of ACTN4 According to Evaluation of Metastatic Ability. Cancers 2022, 14, 4363. https://doi.org/10.3390/cancers14184363
Tozuka T, Noro R, Seike M, Honda K. Benefits from Adjuvant Chemotherapy in Patients with Resected Non-Small Cell Lung Cancer: Possibility of Stratification by Gene Amplification of ACTN4 According to Evaluation of Metastatic Ability. Cancers. 2022; 14(18):4363. https://doi.org/10.3390/cancers14184363
Chicago/Turabian StyleTozuka, Takehiro, Rintaro Noro, Masahiro Seike, and Kazufumi Honda. 2022. "Benefits from Adjuvant Chemotherapy in Patients with Resected Non-Small Cell Lung Cancer: Possibility of Stratification by Gene Amplification of ACTN4 According to Evaluation of Metastatic Ability" Cancers 14, no. 18: 4363. https://doi.org/10.3390/cancers14184363
APA StyleTozuka, T., Noro, R., Seike, M., & Honda, K. (2022). Benefits from Adjuvant Chemotherapy in Patients with Resected Non-Small Cell Lung Cancer: Possibility of Stratification by Gene Amplification of ACTN4 According to Evaluation of Metastatic Ability. Cancers, 14(18), 4363. https://doi.org/10.3390/cancers14184363