Matched-Pair Analysis of Survival in the Patients with Advanced Laryngeal and Hypopharyngeal Squamous Cell Carcinoma Treated with Induction Chemotherapy Plus Chemo-Radiation or Total Laryngectomy
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Patients
2.2. Statistical Analysis
3. Results
3.1. Patient Characteristics
3.2. Organ Preservation Group
3.3. Surgery Group
3.4. Survival Analysis
3.5. Matched Analysis of Survival
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Characteristics | All Patients N = 120 (%) | Surgery Group N = 60 (%) | Organ Preservation Group N = 60 (%) | P1 |
---|---|---|---|---|
Age | ||||
<55 years | 38 (32) | 19 (32) | 19 (32) | Matched |
55–59 years | 28 (23) | 14 (23) | 14 (23) | |
>59 years | 54 (45) | 27 (45) | 27 (45) | |
Gender | ||||
Female | 10 (8) | 5 (8) | 5 (8) | Matched |
Male | 110 (92) | 55 (92) | 55 (92) | |
Alcohol | ||||
No-light drinker | 56 (46) | 34 (56) | 25 (41) | 0.14 |
Moderate-heavy drinker | 64 (54) | 26 (44) | 35 (59) | |
Tobacco | ||||
No-light smoker | 56 (46) | 41 (68) | 15 (25) | 0.1 |
Moderate-heavy smoker | 64 (54) | 19 (32) | 45 (75) | |
Location | ||||
Hypopharynx | 54 (45) | 26 (43) | 28 (47) | |
Larynx | 66 (55) | 34 (57) | 32 (53) | 0.71 |
Glottis | 21 (32) | 12 (35) | 9 (28) | |
Supraglottis | 45 (68) | 22 (65) | 23 (72) | 0.68 |
T classification | ||||
2 | 4 (3) | 2 (3) | 2 (3) | Matched |
3 | 102 (85) | 54 (85) | 54 (85) | |
4 | 14 (12) | 7 (12) | 7 (12) | |
N classification | ||||
N0 | 52 (43) | 26 (43) | 26 (43) | Matched |
N1 | 16 (13) | 8 (13) | 8 (13) | |
N2 | 48 (40) | 24 (40) | 24 (40) | |
N3 | 4 (3) | 2 (3) | 2 (3) | |
Disease stage | ||||
III | 65 (54) | 31 (52) | 34 (57) | 0.9 |
IV | 55 (46) | 29 (48) | 26 (43) | |
Histological grade | ||||
G1 | 43 (36) | 22 (37) | 21 (35) | 0.9 |
G2 | 46 (38) | 22 (37) | 24 (40) | |
G3 | 31 (26) | 16 (26) | 15 (25) | |
Follow-up mean (median), months | 62 (49) | 61 (40) | 63 (54) | 0.41 |
Toxicities | Induction Chemotherapy N = 60 (%) | Concurrent Chemoradiation N = 29 (%) |
---|---|---|
No toxicity | 11 (18) | 4 (14) |
Mucositis | 11 (13) | 25 (86) |
Neutropenia | 3 (5) | 4 (14) |
Diarrhea and sickness | 6 (10) | 12 (41) |
Renal tubulopathy | 8 (13) | 5 (17) |
Radiodermatitis | 0 | 12 (41) |
Other * | 1 | 0 |
Cox’s Regression Analysis on Matching Variables | Value |
---|---|
Overall Survival | |
Hazard ratio | 0.758 |
95% Confidence interval | 0.48–1.18 |
P | 0.22 |
Disease-Specific Survival | |
Hazard ratio | 0.984 |
95% Confidence interval | 0.52–1.83 |
P | 0.96 |
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García-Cabo, P.; López, F.; Sánchez-Canteli, M.; Fernández-Vañes, L.; Álvarez-Marcos, C.; Llorente, J.L.; Rúa, M.Á.d.l.; Blay, P.; Rodrigo, J.P. Matched-Pair Analysis of Survival in the Patients with Advanced Laryngeal and Hypopharyngeal Squamous Cell Carcinoma Treated with Induction Chemotherapy Plus Chemo-Radiation or Total Laryngectomy. Cancers 2021, 13, 1735. https://doi.org/10.3390/cancers13071735
García-Cabo P, López F, Sánchez-Canteli M, Fernández-Vañes L, Álvarez-Marcos C, Llorente JL, Rúa MÁdl, Blay P, Rodrigo JP. Matched-Pair Analysis of Survival in the Patients with Advanced Laryngeal and Hypopharyngeal Squamous Cell Carcinoma Treated with Induction Chemotherapy Plus Chemo-Radiation or Total Laryngectomy. Cancers. 2021; 13(7):1735. https://doi.org/10.3390/cancers13071735
Chicago/Turabian StyleGarcía-Cabo, Patricia, Fernando López, Mario Sánchez-Canteli, Laura Fernández-Vañes, César Álvarez-Marcos, José Luis Llorente, Maria Ángeles de la Rúa, Pilar Blay, and Juan P. Rodrigo. 2021. "Matched-Pair Analysis of Survival in the Patients with Advanced Laryngeal and Hypopharyngeal Squamous Cell Carcinoma Treated with Induction Chemotherapy Plus Chemo-Radiation or Total Laryngectomy" Cancers 13, no. 7: 1735. https://doi.org/10.3390/cancers13071735