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Article

Dynamic Contrast-Enhanced MRI of Prostate Lesions of Simultaneous [68Ga]Ga-PSMA-11 PET/MRI: Comparison between Intraprostatic Lesions and Correlation between Perfusion Parameters

1
Institute of Radiology and Nuclear Medicine, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117 Berlin, Germany
2
Department of Biology, Chemistry and Pharmacy, Institute of Biology, Freie Universität Berlin, Königin-Luise-Str. 1-3, 14195 Berlin, Germany
3
Department of Veterinary Medicine, Institute of Veterinary Pathology, Freie Universität Berlin, Robert-von-Ostertag-Str. 15, Building 12, 14163 Berlin, Germany
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Department of Nuclear Medicine, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1, 13353 Berlin, Germany
5
Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675 Munich, Germany
*
Author to whom correspondence should be addressed.
Academic Editors: Alessio G. Morganti, Mirko D’Onofrio, Maria Antonietta Bali and Maxime Ronot
Cancers 2021, 13(6), 1404; https://doi.org/10.3390/cancers13061404
Received: 13 December 2020 / Revised: 25 February 2021 / Accepted: 16 March 2021 / Published: 19 March 2021
(This article belongs to the Special Issue Advanced Oncologic Imaging)
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is an important method to analyze the perfusion model of tumors, allowing noninvasive quantification of microvascular structure and function. Furthermore, simultaneous [68Ga]Ga-prostate-specific membrane antigen (PSMA)-11 positron emission tomography (PET)/MRI is currently the most advantageous way for assessing prostate cancer staging. Therefore, combining these two examinations helps to diagnose the lesions more comprehensively. Our study analyzes perfusion parameters between intraprostatic lesions and the correlation between perfusion parameters and [68Ga]Ga-PSMA-11 PET. This study highlights the significant effect of PSMA uptake on perfusion parameters.
We aimed to retrospectively compare the perfusion parameters measured from dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) of prostate benign lesions and malignant lesions to determine the relationship between perfusion parameters. DCE-MRI was performed in patients with PCa who underwent simultaneous [68Ga]Ga-prostate-specific membrane antigen (PSMA)-11 positron emission tomography (PET)/MRI. Six perfusion parameters (arrival time (AT), time to peak (TTP), wash-in slope (W-in), wash-out slope (W-out), peak enhancement intensity (PEI), and initial area under the 60-s curve (iAUC)), and a semi-quantitative parameter, standardized uptake values maximum (SUVmax) were calculated by placing regions of interest in the largest area of the lesions. The DCE-MRI parameters between prostate benign and malignant lesions were compared. The DCE-MRI parameters in both the benign and malignant lesions subgroup with SUVmax ≤ 3.0 and SUVmax > 3.0 were compared. The correlation of DCE-MRI parameters was investigated. Malignant lesions demonstrated significantly shorter TTP and higher SUVmax than did benign lesions. In the benign and malignant lesions subgroup, perfusion parameters of lesions with SUVmax ≤ 3.0 show no significant difference to those with SUVmax > 3.0. DCE-MRI perfusion parameters show a close correlation with each other. DCE-MRI parameters reflect the perfusion characteristics of intraprostatic lesions with malignant lesions, demonstrating significantly shorter TTP. There is a moderate to strong correlation between DCE-MRI parameters. Semi-quantitative analysis reflects that malignant lesions show a significantly higher SUVmax than benign lesions. View Full-Text
Keywords: prostate cancer; PSMA; PET/MRI; dynamic contrast-enhanced; arrival time; time to peak; wash-in slope; wash-out slope; peak enhancement intensity; initial area under curve prostate cancer; PSMA; PET/MRI; dynamic contrast-enhanced; arrival time; time to peak; wash-in slope; wash-out slope; peak enhancement intensity; initial area under curve
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MDPI and ACS Style

Zhao, J.; Kader, A.; Mangarova, D.B.; Brangsch, J.; Brenner, W.; Hamm, B.; Makowski, M.R. Dynamic Contrast-Enhanced MRI of Prostate Lesions of Simultaneous [68Ga]Ga-PSMA-11 PET/MRI: Comparison between Intraprostatic Lesions and Correlation between Perfusion Parameters. Cancers 2021, 13, 1404. https://doi.org/10.3390/cancers13061404

AMA Style

Zhao J, Kader A, Mangarova DB, Brangsch J, Brenner W, Hamm B, Makowski MR. Dynamic Contrast-Enhanced MRI of Prostate Lesions of Simultaneous [68Ga]Ga-PSMA-11 PET/MRI: Comparison between Intraprostatic Lesions and Correlation between Perfusion Parameters. Cancers. 2021; 13(6):1404. https://doi.org/10.3390/cancers13061404

Chicago/Turabian Style

Zhao, Jing, Avan Kader, Dilyana B. Mangarova, Julia Brangsch, Winfried Brenner, Bernd Hamm, and Marcus R. Makowski. 2021. "Dynamic Contrast-Enhanced MRI of Prostate Lesions of Simultaneous [68Ga]Ga-PSMA-11 PET/MRI: Comparison between Intraprostatic Lesions and Correlation between Perfusion Parameters" Cancers 13, no. 6: 1404. https://doi.org/10.3390/cancers13061404

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