Long-Term Outcomes of Stereotactic Radiosurgery for Trigeminal, Facial, and Jugular Foramen Schwannoma in Comparison with Vestibular Schwannoma

Shinya, Yuki; Hasegawa, Hirotaka; Shin, Masahiro; Sugiyama, Takehiro; Kawashima, Mariko; Katano, Atsuto; Kashio, Akinori; Kondo, Kenji; Saito, Nobuhito

doi:10.3390/cancers13051140

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Long-Term Outcomes of Stereotactic Radiosurgery for Trigeminal, Facial, and Jugular Foramen Schwannoma in Comparison with Vestibular Schwannoma

^1,*

^1,2

^3,4

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⁵,

⁶,

⁶ and

Department of Neurosurgery, The University of Tokyo Hospital, Tokyo 113-8655, Japan

Department of Neurologic Surgery, Mayo Clinic, Rochester, MN 55905, USA

Diabetes and Metabolism Information Center, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan

⁴

Department of Health Services Research, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan

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Department of Radiology, The University of Tokyo Hospital, Tokyo 113-8655, Japan

⁶

Department of Otorhinolaryngology, The University of Tokyo Hospital, Tokyo 113-8655, Japan

Author to whom correspondence should be addressed.

Academic Editors: Carsten Hagemann and Cordula Matthies

Cancers 2021, 13(5), 1140; https://doi.org/10.3390/cancers13051140

Received: 31 January 2021 / Revised: 27 February 2021 / Accepted: 5 March 2021 / Published: 7 March 2021

(This article belongs to the Special Issue Schwannomas – So-Called Benign Nervous System Tumors)

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Intracranial schwannomas are benign intracranial neoplasms. Vestibular schwannomas (VS) account for 90% of intracranial schwannomas; whereas the other cranial nerve schwannomas, such as trigeminal (TS), facial (FS), and jugular foramen schwannoma (JFS), account for 10% of all cases. Stereotactic radiosurgery (SRS) is a minimally invasive treatment for small to medium VS and known to provide excellent long-term tumor control; however, there remains a paucity of evidence regarding SRS for TS, FS, and JFS due to the rarity of these tumors. We investigated the radiosurgical outcomes of these non-vestibular schwannomas and compared them to those of VS through matched cohort analysis.

Abstract

Stereotactic radiosurgery (SRS) is known to provide excellent tumor control with functional preservation for vestibular schwannomas (VS), but its efficacy in the other major intracranial schwannomas including trigeminal (TS), facial (FS), and jugular foramen schwannomas (JFS) has not been established yet due to their rarity. We retrospectively analyzed data of 514 consecutive patients who had intracranial schwannomas (460 VS, 22 TS, 7 FS, and 25 JFS) and underwent SRS. The 5- and 10-year tumor control rates were 97% and 94% for VS, 100% and 100% for TS, 80% and 80% for FS, and 100% and 80% for JFS. Radiation-induced complications included one hydrocephalus for TS (4.5%), no cases for FS (0%), and one hydrocephalus and one lower palsy for JFS (8.0%). Through matched cohort analysis between patients with VS and each of the non-VS, we found no statistical difference in tumor control and radiation-induced adverse events. SRS seems to provide long-term tumor control with functional preservation for TS, FS and JFS and the efficacies are similar to VS. View Full-Text

Keywords: intracranial schwannomas; stereotactic radiosurgery; long-term outcomes; matched cohort analyses

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MDPI and ACS Style

Shinya, Y.; Hasegawa, H.; Shin, M.; Sugiyama, T.; Kawashima, M.; Katano, A.; Kashio, A.; Kondo, K.; Saito, N. Long-Term Outcomes of Stereotactic Radiosurgery for Trigeminal, Facial, and Jugular Foramen Schwannoma in Comparison with Vestibular Schwannoma. Cancers 2021, 13, 1140. https://doi.org/10.3390/cancers13051140

AMA Style

Shinya Y, Hasegawa H, Shin M, Sugiyama T, Kawashima M, Katano A, Kashio A, Kondo K, Saito N. Long-Term Outcomes of Stereotactic Radiosurgery for Trigeminal, Facial, and Jugular Foramen Schwannoma in Comparison with Vestibular Schwannoma. Cancers. 2021; 13(5):1140. https://doi.org/10.3390/cancers13051140

Chicago/Turabian Style

Shinya, Yuki, Hirotaka Hasegawa, Masahiro Shin, Takehiro Sugiyama, Mariko Kawashima, Atsuto Katano, Akinori Kashio, Kenji Kondo, and Nobuhito Saito. 2021. "Long-Term Outcomes of Stereotactic Radiosurgery for Trigeminal, Facial, and Jugular Foramen Schwannoma in Comparison with Vestibular Schwannoma" Cancers 13, no. 5: 1140. https://doi.org/10.3390/cancers13051140

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Long-Term Outcomes of Stereotactic Radiosurgery for Trigeminal, Facial, and Jugular Foramen Schwannoma in Comparison with Vestibular Schwannoma

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