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Systematic Review

MicroRNA as Epigenetic Modifiers in Endometrial Cancer: A Systematic Review

1
Centre de Recherche Saint-Antoine (CRSA), INSERM UMR_S_938, Cancer Biology and Therapeutics, Sorbonne University, 75012 Paris, France
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Department of Gynecological and Breast Surgery and Oncology, Pitié-Salpêtrière, Assistance Publique des Hôpitaux de Paris (AP-HP), University Hospital, 75013 Paris, France
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Centre de Recherche Saint-Antoine, Equipe Instabilité des Microsatellites et Cancer, Equipe labellisée par la Ligue Nationale contre le Cancer, Unité Mixte de Recherche Scientifique 938 and SIRIC CURAMUS, INSERM, Sorbonne Université, 75012 Paris, France
4
Scarcell Therapeutics, 101 rue de Sèvres, 75006 Paris, France
5
U1016, CNRS, UMR8104, Institut Cochin, INSERM, Université de Paris, 75014 Paris, France
*
Authors to whom correspondence should be addressed.
Academic Editor: Nicoletta Sacchi
Cancers 2021, 13(5), 1137; https://doi.org/10.3390/cancers13051137
Received: 24 December 2020 / Revised: 2 February 2021 / Accepted: 1 March 2021 / Published: 6 March 2021
(This article belongs to the Collection Regulatory and Non-Coding RNAs in Cancer Epigenetic Mechanisms)
Endometrial cancer (EC) is the 2nd most common gynecologic cancer worldwide. MicroRNAs (miRNAs) are small noncoding RNAs that contribute to epigenetic regulation. The objective of this systematic review is to summarize our current knowledge on the role of miRNAs in the epigenetic deregulation of tumor-related genes in EC. It includes all miRNAs reported to be involved in EC including their roles in DNA methylation and RNA-associated silencing. This systematic review should be useful for development of novel strategies to improve diagnosis and risk assessment as well as for new treatments aimed at miRNAs, their target genes or DNA methylation.
The objective of this systematic review is to summarize our current knowledge on the influence of miRNAs in the epigenetic deregulation of tumor-related genes in endometrial cancer (EC). We conducted a literature search on the role of miRNAs in the epigenetic regulation of EC applying the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The following terms were used: microRNA, miRNA, miR, endometrial cancer, endometrium, epigenetic, epimutation, hypermethylation, lynch, deacetylase, DICER, novel biomarker, histone, chromatin. The miRNAs were classified and are presented according to their function (tumor suppressor or onco-miRNA), their targets (when known), their expression levels in EC tissue vs the normal surrounding tissue, and the degree of DNA methylation in miRNA loci and CpG sites. Data were collected from 201 articles, including 190 original articles, published between November 1, 2008 and September 30, 2020 identifying 313 different miRNAs implicated in epigenetic regulation of EC. Overall, we identified a total of 148 miRNAs with decreased expression in EC, 140 miRNAs with increased expression in EC, and 22 miRNAs with discordant expression levels. The literature implicated different epigenetic phenomena including altered miRNA expression levels (miR-182, -230), changes in the methylation of miRNA loci (miR-34b, -129-2, -130a/b, -152, -200b, -625) and increased/decreased methylation of target genes (miR-30d,-191). This work provides an overview of all miRNAs reported to be involved in epigenetic regulation in EC including DNA methylation and RNA-associated silencing. These findings may contribute to novel strategies in diagnosis, risk assessment, and treatments aimed at miRNAs, their target genes or DNA methylation. View Full-Text
Keywords: Epigenetics; MicroRNA; Endometrial cancer; Methylation; miR-182; miR-230; miR-129-2; miR-130a/b; miR-200b; miR-191 Epigenetics; MicroRNA; Endometrial cancer; Methylation; miR-182; miR-230; miR-129-2; miR-130a/b; miR-200b; miR-191
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MDPI and ACS Style

Favier, A.; Rocher, G.; Larsen, A.K.; Delangle, R.; Uzan, C.; Sabbah, M.; Castela, M.; Duval, A.; Mehats, C.; Canlorbe, G. MicroRNA as Epigenetic Modifiers in Endometrial Cancer: A Systematic Review. Cancers 2021, 13, 1137. https://doi.org/10.3390/cancers13051137

AMA Style

Favier A, Rocher G, Larsen AK, Delangle R, Uzan C, Sabbah M, Castela M, Duval A, Mehats C, Canlorbe G. MicroRNA as Epigenetic Modifiers in Endometrial Cancer: A Systematic Review. Cancers. 2021; 13(5):1137. https://doi.org/10.3390/cancers13051137

Chicago/Turabian Style

Favier, Amélia, Grégoire Rocher, Annette K. Larsen, Romain Delangle, Catherine Uzan, Michèle Sabbah, Mathieu Castela, Alex Duval, Céline Mehats, and Geoffroy Canlorbe. 2021. "MicroRNA as Epigenetic Modifiers in Endometrial Cancer: A Systematic Review" Cancers 13, no. 5: 1137. https://doi.org/10.3390/cancers13051137

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