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Cancers
Volume 13
Issue 15
10.3390/cancers13153919
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Review
Peer-Review Record

Biomarkers and Lung Cancer Early Detection: State of the Art

Cancers 2021, 13(15), 3919; https://doi.org/10.3390/cancers13153919
by Elisa Dama 1,†, Tommaso Colangelo 1,†, Emanuela Fina 2, Marco Cremonesi 3, Marinos Kallikourdis 3,4, Giulia Veronesi 5,‡ and Fabrizio Bianchi 1,*,‡
Reviewer 1: Anonymous
Reviewer 2:
Rafael Rosell
Reviewer 3: Anonymous
Cancers 2021, 13(15), 3919; https://doi.org/10.3390/cancers13153919
Submission received: 28 May 2021 / Revised: 23 July 2021 / Accepted: 29 July 2021 / Published: 3 August 2021
(This article belongs to the Special Issue Cancer Biomarkers in Body Fluids)

Round 1

Reviewer 1 Report

I have no special comments to the authors

Author Response

please see the attached rebuttal letter

Author Response File: Author Response.pdf

Reviewer 2 Report

Certainly a very informative and complete review. However I have several concerns and/or provisos.
1. Abstract is not informative.
2. There are no clear conclusions.
3.There are no statements on the limitations of the review.
4. I cannot see what could be if any the method to discern benign lung nodes from lung cancer.
5. I cannot see  ROC AUC for the studies mentioned.
6. In addition to the Tables, a sub-group analysis Forest plot including AUCs could be of great guidance.
7. I cannot see studies on platelets. Se Best et al. RNA-Seq of tumor-educated platelets enables blood-based pan-cancer, multiclass, and molecular pathway cancer diagnostics. Cancer Cell 2015, Best et al. Swarm intelligence-enhanced detection of non-small cell lung cancer using tumor-educated platelets. Cancer Cell 2017.


Author Response

please see the attached rebuttal letter

Author Response File: Author Response.pdf

Reviewer 3 Report

In my opinion the idea of the evaluated review type paper is on time. However,  I have few comments addressed to authors:

  1. The numerous information that were described is already well-known and there is lack of necessity to repeat it again. It is better to touch most recent findings. Authors, should focus on the new markers such as lncRNAs, circRNAs and pri-miRNAs, that are still not well known.
  2. The most important clusters of markers should be summarized in tables. Unfortunately, there is a deficit of specific markers and described too generally.
  3. As mentioned above, the more precise screening of the latest literature reports should be made.
  4.  Some discussion on the pros and cons of molecular markers for LC should be introduced to manuscript body.

Author Response

please see the attached rebuttal letter

Author Response File: Author Response.pdf

Round 2

Reviewer 2 Report

I have no additional comments to add.

Reviewer 3 Report

Authors corrected paper according to reviewer's comments.

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