68Ga-DOTATOC-PET/MRI—A Secure One-Stop Shop Imaging Tool for Robotic Radiosurgery Treatment Planning in Patients with Optic Nerve Sheath Meningioma

Department of Nuclear Medicine, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, 13353 Berlin, Germany

Department of Radiation Oncology, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, 13353 Berlin, Germany

Berlin Institute of Health at Charité—Universitätsmedizin Berlin, BIH Academy, Clinician Scientist Program, 10117 Berlin, Germany

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Department of Neurosurgery, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, 10117 Berlin, Germany

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Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, 81675 Munich, Germany

Author to whom correspondence should be addressed.

Academic Editor: Brigitta G. Baumert

Cancers 2021, 13(13), 3305; https://doi.org/10.3390/cancers13133305

Received: 20 May 2021 / Revised: 15 June 2021 / Accepted: 16 June 2021 / Published: 1 July 2021

(This article belongs to the Special Issue State-of-the-Art Research in Meningioma)

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Through combined information about spatial spread in magnetic resonance imaging (MRI) and positron emission tomography (PET), gallium-68-labeled (DOTA0-Phe1-Tyr3) octreotide (Ga68-DOTATOC) PET/MRI before radiosurgery allows safe treatment planning for optic nerve sheath meningiomas (ONSM). Moreover, because of specific receptor stocking, diagnostic accuracy is improved without the need for biopsy. Thus, Ga68-DOTATOC-PET/MRI can be considered a safe “one-stop shop” image tool prior to radiosurgery for ONSM.

Abstract

Optic nerve sheath meningiomas (ONSM) are rare but can lead to irreversible blindness. Hybrid imaging may enhance tumor delineation and diagnostic accuracy via receptor binding. However, relevant clinical data for ONSM are lacking. We evaluated the feasibility of receptor-based hybrid imaging prior to robotic radiosurgery (RRS). We retrospectively analyzed all of our institution’s patients with suspected ONSM who underwent combined positron emission tomography and magnetic resonance imaging (PET/MRI) with gallium-68-labeled (DOTA0-Phe1-Tyr3) octreotide (Ga68-DOTATOC) before RRS between 2018 and 2019. Eight patients with ten suspected ONSM (female = 7; median age, 51.2 years; IQR, 43.0–66.0) were included. Nine out of ten ONSM were deemed PET-positive with a median standard uptake value (SUV) max of 5.6 (IQR, 2.6–7.8). For all nine ONSM that presented 68Ga-DOTATOC uptake, hybrid PET/MRI was used for target volume contouring prior to RSS. At a median follow-up of 11.7 months (IQR, 9.4–16.4), tumor control was achieved in all patients. Radiosurgery resulted in the improvement of visual acuity in two of eight patients, whereas six showed stable vision. Ga68-DOTATOC-PET/MRI can be used for target volume contouring prior to RRS for ONSM as it enables safe treatment planning and improves diagnostic accuracy. View Full-Text

Keywords: 68Ga-DOTATOC; hybrid imaging; optic nerve sheath meningioma; PET/MRI; robotic radiosurgery; stereotactic radiotherapy

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MDPI and ACS Style

Graef, J.; Furth, C.; Kluge, A.K.; Acker, G.; Kord, M.; Zimmermann, Z.; Amthauer, H.; Makowski, M.; Loebel, F.; Vajkoczy, P.; Budach, V.; Senger, C. 68Ga-DOTATOC-PET/MRI—A Secure One-Stop Shop Imaging Tool for Robotic Radiosurgery Treatment Planning in Patients with Optic Nerve Sheath Meningioma. Cancers 2021, 13, 3305. https://doi.org/10.3390/cancers13133305

AMA Style

Graef J, Furth C, Kluge AK, Acker G, Kord M, Zimmermann Z, Amthauer H, Makowski M, Loebel F, Vajkoczy P, Budach V, Senger C. 68Ga-DOTATOC-PET/MRI—A Secure One-Stop Shop Imaging Tool for Robotic Radiosurgery Treatment Planning in Patients with Optic Nerve Sheath Meningioma. Cancers. 2021; 13(13):3305. https://doi.org/10.3390/cancers13133305

Chicago/Turabian Style

Graef, Josefine, Christian Furth, Anne Kathrin Kluge, Gueliz Acker, Melina Kord, Zoe Zimmermann, Holger Amthauer, Marcus Makowski, Franziska Loebel, Peter Vajkoczy, Volker Budach, and Carolin Senger. 2021. "68Ga-DOTATOC-PET/MRI—A Secure One-Stop Shop Imaging Tool for Robotic Radiosurgery Treatment Planning in Patients with Optic Nerve Sheath Meningioma" Cancers 13, no. 13: 3305. https://doi.org/10.3390/cancers13133305

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68Ga-DOTATOC-PET/MRI—A Secure One-Stop Shop Imaging Tool for Robotic Radiosurgery Treatment Planning in Patients with Optic Nerve Sheath Meningioma

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