68Ga-DOTATOC-PET/MRI—A Secure One-Stop Shop Imaging Tool for Robotic Radiosurgery Treatment Planning in Patients with Optic Nerve Sheath Meningioma
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. 68 Ga-DOTATOC PET/MRI
2.3. RRS
2.4. Follow-Up
2.5. Literature Review
3. Results
3.1. Patients’ Characteristics
3.2. 68 Ga-DOTATOC-PET/MRI
3.3. RRS
3.4. Follow-Up
3.5. Literature Review
4. Discussion
Limitations
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Pre-Radiosurgery | Post-Radiosurgery |
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blind | blind |
0.2 | 0.8 |
0.6 | 0.8 |
light/dark | light/dark |
1 | 1 |
blind | blind |
0.9 | 0.9 |
0.7 | 0.7 |
0.05 | 0.05 |
blind | blind |
Author/Study Type | Year | Number of Patients | Tumor Type | Scanner | Diagnostic Predictability and Use for Radiotherapy Planning | Limitations |
---|---|---|---|---|---|---|
Acker, G. [16]/ Retrospective study | 2019 | 10 | meningiomas | PET/MRI (Biograph mMR, Siemens Healthcare GmbH) | Impact on target volume, contouring of skull-based meningiomas, radiosurgery treatment planning | Small number of patients; lack of standardization for PET data interpretation |
Afshar-Oromieh, A. [19]/ Comparative single cohort study | 2015 | 15 | meningiomas | PET/MRI (Biograph mMR; Siemens Healthcare GmbH) | Ideal combination of high sensitivity/specificity (PET) and best morphological visualization (MRI); distinction between pituitary gland and meningioma can be difficult | Small number of patients; differences in tracer uptake values in PET/CT and PET/MRI possibly due to different detectors or algorithms of measurement; no histological confirmation of meningioma diagnosis for every lesion |
Thorwarth, D. [24]/ Case report | 2011 | 1 | meningiomas | APD based PET detector inserted in a Magnetom Trio MRI (Brain PET; Siemens Healthcare)PET/CT (Biograph HiRez 16, Siemens Healthcare GmbH) | Possibly beneficial for target volume definition | Case report; lack of standardization for PET data interpretation; after tracer injection decay between PET/CT and PET/MR image acquisition; compensating prolonged acquisition protocol in PET/MRI |
Boss, A. [25]/ Comparative single cohort study | 2010 | 3 | meningiomas | APD based PET detector inserted in a Magnetom Trio MRI (BrainPET; Siemens Healthcare GmbH);PET/CT (Hi-Rez Biograph 16; Siemens Healthcare GmbH) | Image quality + quantitative data achieved using PET/MRI similar to PET/CT: meanpaired difference of the tumor volumes was 0.2 × 6 × 1.3 cm3; advantages such as higher soft-tissue contrast, reduced radiation exposure, and advanced MRI techniques | Without 4 mm Gaussian filter slight streak artifacts; after tracer injection decay between PET/CT and PET/MR image acquisition |
Al Feghali, K. A. [6]/ Case report | 2018 | 1 | ONSM | PET/CT (n/a) | Probable, not definitive | Lack of biopsy |
Klingenstein, A. [7]/ Prospective study | 2015 | 10 | ONSM | PET/CT (Biograph 64 TruePoint; Siemens Healthcare GmbH; Discovery 64-slice; GE Healthcare) | 100% specificity; 100% sensitivity | Small number of patients; histological proof only in 5 patients |
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Graef, J.; Furth, C.; Kluge, A.K.; Acker, G.; Kord, M.; Zimmermann, Z.; Amthauer, H.; Makowski, M.; Loebel, F.; Vajkoczy, P.; et al. 68Ga-DOTATOC-PET/MRI—A Secure One-Stop Shop Imaging Tool for Robotic Radiosurgery Treatment Planning in Patients with Optic Nerve Sheath Meningioma. Cancers 2021, 13, 3305. https://doi.org/10.3390/cancers13133305
Graef J, Furth C, Kluge AK, Acker G, Kord M, Zimmermann Z, Amthauer H, Makowski M, Loebel F, Vajkoczy P, et al. 68Ga-DOTATOC-PET/MRI—A Secure One-Stop Shop Imaging Tool for Robotic Radiosurgery Treatment Planning in Patients with Optic Nerve Sheath Meningioma. Cancers. 2021; 13(13):3305. https://doi.org/10.3390/cancers13133305
Chicago/Turabian StyleGraef, Josefine, Christian Furth, Anne Kathrin Kluge, Gueliz Acker, Melina Kord, Zoe Zimmermann, Holger Amthauer, Marcus Makowski, Franziska Loebel, Peter Vajkoczy, and et al. 2021. "68Ga-DOTATOC-PET/MRI—A Secure One-Stop Shop Imaging Tool for Robotic Radiosurgery Treatment Planning in Patients with Optic Nerve Sheath Meningioma" Cancers 13, no. 13: 3305. https://doi.org/10.3390/cancers13133305