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Review

Clinical Results of Fibroblast Activation Protein (FAP) Specific PET and Implications for Radiotherapy Planning: Systematic Review

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Department of Radiation Oncology, Kantonsspital Winterthur, 8400 Winterthur, Switzerland
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Department of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany
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Heidelberg Institute of Radiation Oncology (HIRO), 69120 Heidelberg, Germany
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National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany
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Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
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Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany
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German Cancer Consortium (DKTK), 69120 Heidelberg, Germany
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Department of Nuclear Medicine, Heidelberg University Hospital, 69120 Heidelberg, Germany
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Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
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Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), 69120 Heidelberg, Germany
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Author to whom correspondence should be addressed.
Cancers 2020, 12(9), 2629; https://doi.org/10.3390/cancers12092629
Received: 29 July 2020 / Revised: 28 August 2020 / Accepted: 12 September 2020 / Published: 15 September 2020
(This article belongs to the Section Clinical Trials of Cancer)
The purpose of this systematic review is to summarize the findings of using fibroblast activation protein (FAP) as a new tracer for positron emission tomography (PET) in cancer patients. In the 19 included studies, FAP was evaluated in various cancers and showed promising initial results for staging as well as radiotherapy planning.
Small molecules targeting fibroblast activation protein (FAP) have emerged as a new group of tracers for positron emission tomography (PET) in 2018. The purpose of this systematic review is therefore to summarize the evidence that has been gathered to date in patients and to discuss its possible implications for radiotherapy planning. The MEDLINE database was searched for the use of FAP-specific PET in cancer patients and the records were screened according to PRISMA guidelines. Nineteen studies were included. While dedicated analyses of FAP-specific PET for radiotherapy planning were available for glioblastoma, head and neck cancers, lung cancer, and tumors of the lower gastrointestinal tract, there is still very limited data for several epidemiologically significant cancers. In conclusion, FAP-specific PET represents a promising imaging modality for radiotherapy planning that warrants further research. View Full-Text
Keywords: fibroblast activation protein; positron emission tomography; radiotherapy; staging; positron emission tomography-computed tomography; PET; PET-CT fibroblast activation protein; positron emission tomography; radiotherapy; staging; positron emission tomography-computed tomography; PET; PET-CT
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MDPI and ACS Style

Windisch, P.; Zwahlen, D.R.; Koerber, S.A.; Giesel, F.L.; Debus, J.; Haberkorn, U.; Adeberg, S. Clinical Results of Fibroblast Activation Protein (FAP) Specific PET and Implications for Radiotherapy Planning: Systematic Review. Cancers 2020, 12, 2629. https://doi.org/10.3390/cancers12092629

AMA Style

Windisch P, Zwahlen DR, Koerber SA, Giesel FL, Debus J, Haberkorn U, Adeberg S. Clinical Results of Fibroblast Activation Protein (FAP) Specific PET and Implications for Radiotherapy Planning: Systematic Review. Cancers. 2020; 12(9):2629. https://doi.org/10.3390/cancers12092629

Chicago/Turabian Style

Windisch, Paul, Daniel R. Zwahlen, Stefan A. Koerber, Frederik L. Giesel, Jürgen Debus, Uwe Haberkorn, and Sebastian Adeberg. 2020. "Clinical Results of Fibroblast Activation Protein (FAP) Specific PET and Implications for Radiotherapy Planning: Systematic Review" Cancers 12, no. 9: 2629. https://doi.org/10.3390/cancers12092629

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