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Open AccessArticle

Understanding and Attitudes toward Cancer Clinical Trials among Patients with a Cancer Diagnosis: National Study through Cancer Trials Ireland

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UCD Conway Institute Dublin, D04V1W8 Dublin, Ireland
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UCD School of Medicine, Mater Misericordiae University Hospital Dublin, D07AX57 Dublin, Ireland
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Cancer Trials Ireland, Innovation House, Old Finglas Road, Glasnevin, D11KXN4 Dublin, Ireland
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Cork University Hospital, T12DFK4 Cork, Ireland
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University Hospital Waterford, X91ER8E Waterford, Ireland
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St. Vincent University Hospital, D04YN63 Dublin, Ireland
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Adelaide & Meath Hospital Incorporating the National Children’s Hospital (AMNCH), D24KNE0 Dublin, Ireland
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Beaumont Hospital, D09A0KH Dublin, Ireland
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Galway University Hospital, SW4794 Galway, Ireland
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Sligo General Hospital, F91H684 Sligo, Ireland
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Bon Secours Hospital, T12DV56 Cork, Ireland
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Letterkenny General Hospital, F92FC82 Donegal, Ireland
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Beacon Hospital, D18AK68 Dublin, Ireland
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St. Luke’s Radiation Oncology Network, St Luke’s Hospital, Rathgar, D06HH36 Dublin, Ireland
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St. James’s Hospital, D08W9RT Dublin, Ireland
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Authors to whom correspondence should be addressed.
Cancers 2020, 12(7), 1921; https://doi.org/10.3390/cancers12071921
Received: 5 June 2020 / Revised: 11 July 2020 / Accepted: 13 July 2020 / Published: 16 July 2020
Cancer clinical trials (CCTs) are critical to translation and development of better therapies to improve outcomes. CCTs require adequate patient involvement but accrual rates are low globally. Several known barriers impede participation and knowing how subpopulations differ in understanding of CCTs can foster targeted approaches to aid accrual and advance cancer treatments. We conducted the first nationwide survey of 1089 patients attending 14 Irish cancer centres, assessing understanding of fundamental concepts in CCT methodology and factors that influence participation, to help tailor patient support for accrual to CCTs. Two-thirds (66%) of patients reported never having been offered a CCT and only 5% of those not offered asked to participate. Misunderstanding of clinical equipoise was prevalent. There were differences in understanding of randomisation of treatment by age (p < 0.0001), ethnicity (p = 0.035) and marital status (p = 0.013), and 58% of patients and 61% previous CCT participants thought that their doctor would ensure better treatment in CCTs. Females were slightly more risk averse. Males indicated a greater willingness to participate in novel drug trials (p = 0.001, p = 0.003). The study identified disparities in several demographics; older, widowed, living in provincial small towns and fewer years-educated patients had generally poorer understanding of CCTs, highlighting requirements for targeted support in these groups. View Full-Text
Keywords: cancer; clinical trials; patient perception; understanding cancer; clinical trials; patient perception; understanding
MDPI and ACS Style

Kearns, C.; Feighery, R.; Mc Caffrey, J.; Higgins, M.; Smith, M.; Murphy, V.; O’Reilly, S.; Horgan, A.M.; Walshe, J.; McDermott, R.; Morris, P.G.; Keane, M.; Martin, M.; Murphy, C.; Duffy, K.; Mihai, A.; Armstrong, J.; O’Donnell, D.M.; Gallagher, W.M.; Kelly, C.M.; Kelly, C.M. Understanding and Attitudes toward Cancer Clinical Trials among Patients with a Cancer Diagnosis: National Study through Cancer Trials Ireland. Cancers 2020, 12, 1921. https://doi.org/10.3390/cancers12071921

AMA Style

Kearns C, Feighery R, Mc Caffrey J, Higgins M, Smith M, Murphy V, O’Reilly S, Horgan AM, Walshe J, McDermott R, Morris PG, Keane M, Martin M, Murphy C, Duffy K, Mihai A, Armstrong J, O’Donnell DM, Gallagher WM, Kelly CM, Kelly CM. Understanding and Attitudes toward Cancer Clinical Trials among Patients with a Cancer Diagnosis: National Study through Cancer Trials Ireland. Cancers. 2020; 12(7):1921. https://doi.org/10.3390/cancers12071921

Chicago/Turabian Style

Kearns, Cathriona; Feighery, Ronan; Mc Caffrey, John; Higgins, Michaela; Smith, Martina; Murphy, Verena; O’Reilly, Seamus; Horgan, Anne M.; Walshe, Janice; McDermott, Ray; Morris, Patrick G.; Keane, Maccon; Martin, Michael; Murphy, Conleth; Duffy, Karen; Mihai, Alina; Armstrong, John; O’Donnell, Dearbhaile M.; Gallagher, William M.; Kelly, Ciara M.; Kelly, Catherine M. 2020. "Understanding and Attitudes toward Cancer Clinical Trials among Patients with a Cancer Diagnosis: National Study through Cancer Trials Ireland" Cancers 12, no. 7: 1921. https://doi.org/10.3390/cancers12071921

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