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Open AccessArticle

Male Sexual Function after Allogeneic Hematopoietic Stem Cell Transplantation in Childhood: A Multicenter Study

1
Department of Psychology and Logopedics, University of Helsinki, P.O. Box 21, 00014 Helsinki, Finland
2
Department of Pediatrics and Adolescent Medicine, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark
3
Division of Haematology-Oncology and Stem Cell Transplantation, New Children’s Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital, 00029 Helsinki, Finland
4
Department of Pediatrics and Adolescent Medicine, Turku University Hospital and Turku University, 20520 Turku, Finland
5
Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark
6
Institute for Inflammation Research, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark
7
NORDFERTIL Research Lab Stockholm, Department of Women’s and Children’s Health, Karolinska Institutet and University Hospital, 17164 Stockholm, Sweden
*
Author to whom correspondence should be addressed.
Cancers 2020, 12(7), 1786; https://doi.org/10.3390/cancers12071786
Received: 19 May 2020 / Revised: 28 June 2020 / Accepted: 30 June 2020 / Published: 4 July 2020
(This article belongs to the Special Issue Symptoms and Side Effects in Cancer Survivors)
There are many known endocrine complications after allogeneic hematopoietic stem cell transplantation (HSCT) in childhood including increased risk of biochemical hypogonadism. However, little is known about sexuality in adulthood following childhood HSCT. In this multicenter study, sexual functions and possible risk factors were assessed comprehensively in two national cohorts (Finland and Denmark) of male adult survivors of childhood HSCT. Compared to a healthy control group (n = 56), HSCT survivors (n = 97) reported less sexual fantasies, poorer orgasms, lower sexual activity with a partner and reduced satisfaction with their sex life, even in the presence of normal erectile functions and a similar frequency of autoerotic acts. Of the HSCT survivors, 35% were cohabitating/married and 66% were sexually active. Risk factors for poorer self-reported sexual functions were partner status (not cohabitating with a partner), depressive symptoms, CNS and testicular irradiation. Sexual dysfunction increased by age in the HSCT group with a pace comparable to that of the control group. However, because of the lower baseline level of sexual functions in the HSCT group, they will reach the level of clinically significant dysfunction at a younger age. Hence, male survivors of childhood HSCT should be interviewed in detail about their sexual health beyond erectile functions. View Full-Text
Keywords: HSCT; children; long-term survivors; pediatric cancer; sexual dysfunction; late effects HSCT; children; long-term survivors; pediatric cancer; sexual dysfunction; late effects
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MDPI and ACS Style

Haavisto, A.; Mathiesen, S.; Suominen, A.; Lähteenmäki, P.; Sørensen, K.; Ifversen, M.; Juul, A.; Mejdahl Nielsen, M.; Müller, K.; Jahnukainen, K. Male Sexual Function after Allogeneic Hematopoietic Stem Cell Transplantation in Childhood: A Multicenter Study. Cancers 2020, 12, 1786. https://doi.org/10.3390/cancers12071786

AMA Style

Haavisto A, Mathiesen S, Suominen A, Lähteenmäki P, Sørensen K, Ifversen M, Juul A, Mejdahl Nielsen M, Müller K, Jahnukainen K. Male Sexual Function after Allogeneic Hematopoietic Stem Cell Transplantation in Childhood: A Multicenter Study. Cancers. 2020; 12(7):1786. https://doi.org/10.3390/cancers12071786

Chicago/Turabian Style

Haavisto, Anu; Mathiesen, Sidsel; Suominen, Anu; Lähteenmäki, Päivi; Sørensen, Kaspar; Ifversen, Marianne; Juul, Anders; Mejdahl Nielsen, Malene; Müller, Klaus; Jahnukainen, Kirsi. 2020. "Male Sexual Function after Allogeneic Hematopoietic Stem Cell Transplantation in Childhood: A Multicenter Study" Cancers 12, no. 7: 1786. https://doi.org/10.3390/cancers12071786

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