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Quantitative Analysis of Differential Expression of HOX Genes in Multiple Cancers

1
The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290002, Israel
2
School of Electrical and Computer Engineering, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel
3
Department of Pathology, Hadassah Medical Center, Jerusalem 9112102, Israel
*
Authors to whom correspondence should be addressed.
Cancers 2020, 12(6), 1572; https://doi.org/10.3390/cancers12061572
Received: 27 May 2020 / Revised: 6 June 2020 / Accepted: 11 June 2020 / Published: 14 June 2020
(This article belongs to the Section Systematic Review or Meta-Analysis in Cancer Research)
Transcription factors encoded by Homeobox (HOX) genes play numerous key functions during early embryonic development and differentiation. Multiple reports have shown that mis-regulation of HOX gene expression plays key roles in the development of cancers. Their expression levels in cancers tend to differ based on tissue and tumor type. Here, we performed a comprehensive analysis comparing HOX gene expression in different cancer types, obtained from The Cancer Genome Atlas (TCGA), with matched healthy tissues, obtained from Genotype-Tissue Expression (GTEx). We identified and quantified differential expression patterns that confirmed previously identified expression changes and highlighted new differential expression signatures. We discovered differential expression patterns that are in line with patient survival data. This comprehensive and quantitative analysis provides a global picture of HOX genes’ differential expression patterns in different cancer types. View Full-Text
Keywords: HOX genes; cancer; transcription factors; differential expression analysis; patient survival HOX genes; cancer; transcription factors; differential expression analysis; patient survival
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MDPI and ACS Style

Adato, O.; Orenstein, Y.; Kopolovic, J.; Juven-Gershon, T.; Unger, R. Quantitative Analysis of Differential Expression of HOX Genes in Multiple Cancers. Cancers 2020, 12, 1572. https://doi.org/10.3390/cancers12061572

AMA Style

Adato O, Orenstein Y, Kopolovic J, Juven-Gershon T, Unger R. Quantitative Analysis of Differential Expression of HOX Genes in Multiple Cancers. Cancers. 2020; 12(6):1572. https://doi.org/10.3390/cancers12061572

Chicago/Turabian Style

Adato, Orit, Yaron Orenstein, Juri Kopolovic, Tamar Juven-Gershon, and Ron Unger. 2020. "Quantitative Analysis of Differential Expression of HOX Genes in Multiple Cancers" Cancers 12, no. 6: 1572. https://doi.org/10.3390/cancers12061572

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