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Open AccessReview

BRAF Mutated Colorectal Cancer: New Treatment Approaches

1
Medical Oncology Department, University Hospital Ramon y Cajal, 28034 Madrid, Spain
2
CIBERONC, The Ramón y Cajal Health Research Institute (IRYCIS), 28034 Madrid, Spain
3
Medicine School, Alcalá University, 28805 Madrid, Spain
4
Biomarkers and Therapeutic Targets Group and Core Facility, The Ramón y Cajal Health Research Institute (IRYCIS), CIBERONC, 28034 Madrid, Spain
5
Pathology department, University Hospital Ramon y Cajal, 28034 Madrid, Spain
6
Department of Medical Oncology, MD Anderson Cancer Center, 28033 Madrid, Spain
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Cancers 2020, 12(6), 1571; https://doi.org/10.3390/cancers12061571
Received: 22 May 2020 / Revised: 9 June 2020 / Accepted: 10 June 2020 / Published: 14 June 2020
(This article belongs to the Special Issue Targeting Solid Tumors)
Colon cancer is one of the most frequently diagnosed malignancies in adults, considering both its incidence and prevalence. Anatomically, the right colon is considered as being from the cecum to the splenic flexure, and the left colon is from the splenic flexure to the rectum. Sidedness is a surrogate of a wide spectrum of colorectal cancer (CRC) biology features (embryology, microbiome, methylation, microsatellite instability (MSI), BRAF, aging, KRAS, consensus molecular subtypes (CMS), etc.), which result in prognostic factors. Different molecular subtypes have been identified, according to genomic and transcriptomic criteria. A subgroup harboring a BRAF mutation has been described, and represents approximately 10% of the patients diagnosed with colon cancer. This subgroup has morphological, clinical, and therapeutic characteristics that differ substantially from patients who do not carry this genetic alteration. Unfortunately, there is no established standard of care for this particular cohort of patients. This manuscript aims to study the biology of this subgroup of colon cancer, to understand the current approach in clinical research. View Full-Text
Keywords: BRAF; colorectal cancer; tyrosine kinases; immunotherapy; CXCR4 BRAF; colorectal cancer; tyrosine kinases; immunotherapy; CXCR4
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MDPI and ACS Style

Molina-Cerrillo, J.; San Román, M.; Pozas, J.; Alonso-Gordoa, T.; Pozas, M.; Conde, E.; Rosas, M.; Grande, E.; García-Bermejo, M.L.; Carrato, A. BRAF Mutated Colorectal Cancer: New Treatment Approaches. Cancers 2020, 12, 1571. https://doi.org/10.3390/cancers12061571

AMA Style

Molina-Cerrillo J, San Román M, Pozas J, Alonso-Gordoa T, Pozas M, Conde E, Rosas M, Grande E, García-Bermejo ML, Carrato A. BRAF Mutated Colorectal Cancer: New Treatment Approaches. Cancers. 2020; 12(6):1571. https://doi.org/10.3390/cancers12061571

Chicago/Turabian Style

Molina-Cerrillo, Javier; San Román, María; Pozas, Javier; Alonso-Gordoa, Teresa; Pozas, Miguel; Conde, Elisa; Rosas, Marta; Grande, Enrique; García-Bermejo, María L.; Carrato, Alfredo. 2020. "BRAF Mutated Colorectal Cancer: New Treatment Approaches" Cancers 12, no. 6: 1571. https://doi.org/10.3390/cancers12061571

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