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Radiation-Induced Lung Fibrosis: Preclinical Animal Models and Therapeutic Strategies

by 1,†, 1,†, 1, 1, 2,*,† and 1,*,†
1
Graduate School of Pharmaceutical Sciences and College of Pharmacy, Ewha Womans University, Seoul 03760, Korea
2
Department of Radiation Oncology, Yonsei University Health System, Seoul 03722, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Cancers 2020, 12(6), 1561; https://doi.org/10.3390/cancers12061561
Received: 20 May 2020 / Revised: 2 June 2020 / Accepted: 10 June 2020 / Published: 12 June 2020
Radiation-induced lung injury (RILI), including acute radiation pneumonitis and chronic radiation-induced lung fibrosis, is the most common side effect of radiation therapy. RILI is a complicated process that causes the accumulation, proliferation, and differentiation of fibroblasts and, finally, results in excessive extracellular matrix deposition. Currently, there are no approved treatment options for patients with radiation-induced pulmonary fibrosis (RIPF) partly due to the absence of effective targets. Current research advances include the development of small animal models reflecting modern radiotherapy, an understanding of the molecular basis of RIPF, and the identification of candidate drugs for prevention and treatment. Insights provided by this research have resulted in increased interest in disease progression and prognosis, the development of novel anti-fibrotic agents, and a more targeted approach to the treatment of RIPF. View Full-Text
Keywords: radiation; lung fibrosis; animal models; antifibrotic; therapeutic targets radiation; lung fibrosis; animal models; antifibrotic; therapeutic targets
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Jin, H.; Yoo, Y.; Kim, Y.; Kim, Y.; Cho, J.; Lee, Y.-S. Radiation-Induced Lung Fibrosis: Preclinical Animal Models and Therapeutic Strategies. Cancers 2020, 12, 1561.

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