Next Article in Journal
microRNAs and Markers of Neutrophil Activation as Predictors of Early Incidental Post-Surgical Pulmonary Embolism in Patients with Intracranial Tumors
Next Article in Special Issue
The Lipase/Amylase Ratio (LAR) in Peripheral Blood Might Represent a Novel Prognostic Marker in Patients with Surgically Resectable Pancreatic Cancer
Previous Article in Journal
A Driver Never Works Alone—Interplay Networks of Mutant p53, MYC, RAS, and Other Universal Oncogenic Drivers in Human Cancer
Previous Article in Special Issue
Glutathione S-Transferase pi-1 Knockdown Reduces Pancreatic Ductal Adenocarcinoma Growth by Activating Oxidative Stress Response Pathways
Article

Systemic Proteome Alterations Linked to Early Stage Pancreatic Cancer in Diabetic Patients

1
The Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
2
Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
3
Department of Neurosurgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
4
Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
5
Department of Medicine, Mayo Clinic, Rochester, MN 55902, USA
6
Division of Gastroenterology, Department of Medicine, the University of Washington, Seattle, WA 98195, USA
7
Proteomics Resource, The University of Washington, Seattle, WA 98109, USA
8
Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally.
Cancers 2020, 12(6), 1534; https://doi.org/10.3390/cancers12061534
Received: 15 May 2020 / Revised: 5 June 2020 / Accepted: 7 June 2020 / Published: 11 June 2020
(This article belongs to the Special Issue Pancreatic Ductal Adenocarcinoma)
Background: Diabetes is a risk factor associated with pancreatic ductal adenocarcinoma (PDAC), and new adult-onset diabetes can be an early sign of pancreatic malignancy. Development of blood-based biomarkers to identify diabetic patients who warrant imaging tests for cancer detection may represent a realistic approach to facilitate earlier diagnosis of PDAC in a risk population. Methods: A spectral library-based proteomic platform was applied to interrogate biomarker candidates in plasma samples from clinically well-defined diabetic cohorts with and without PDAC. Random forest algorithm was used for prediction model building and receiver operating characteristic (ROC) curve analysis was applied to evaluate the prediction probability of potential biomarker panels. Results: Several biomarker panels were cross-validated in the context of detection of PDAC within a diabetic background. In combination with carbohydrate antigen 19-9 (CA19-9), the panel, which consisted of apolipoprotein A-IV (APOA4), monocyte differentiation antigen CD14 (CD14), tetranectin (CLEC3B), gelsolin (GSN), histidine-rich glycoprotein (HRG), inter-alpha-trypsin inhibitor heavy chain H3 (ITIH3), plasma kallikrein (KLKB1), leucine-rich alpha-2-glycoprotein (LRG1), pigment epithelium-derived factor (SERPINF1), plasma protease C1 inhibitor (SERPING1), and metalloproteinase inhibitor 1 (TIMP1), demonstrated an area under curve (AUC) of 0.85 and a two-fold increase in detection accuracy compared to CA19-9 alone. The study further evaluated the correlations of protein candidates and their influences on the performance of biomarker panels. Conclusions: Proteomics-based multiplex biomarker panels improved the detection accuracy for diagnosis of early stage PDAC in diabetic patients. View Full-Text
Keywords: proteomics; pancreatic cancer; pancreatic ductal adenocarcinoma; diabetes; mass spectrometry; plasma; biomarker proteomics; pancreatic cancer; pancreatic ductal adenocarcinoma; diabetes; mass spectrometry; plasma; biomarker
Show Figures

Figure 1

MDPI and ACS Style

Peng, H.; Pan, S.; Yan, Y.; Brand, R.E.; Petersen, G.M.; Chari, S.T.; Lai, L.A.; Eng, J.K.; Brentnall, T.A.; Chen, R. Systemic Proteome Alterations Linked to Early Stage Pancreatic Cancer in Diabetic Patients. Cancers 2020, 12, 1534. https://doi.org/10.3390/cancers12061534

AMA Style

Peng H, Pan S, Yan Y, Brand RE, Petersen GM, Chari ST, Lai LA, Eng JK, Brentnall TA, Chen R. Systemic Proteome Alterations Linked to Early Stage Pancreatic Cancer in Diabetic Patients. Cancers. 2020; 12(6):1534. https://doi.org/10.3390/cancers12061534

Chicago/Turabian Style

Peng, Hong; Pan, Sheng; Yan, Yuanqing; Brand, Randall E.; Petersen, Gloria M.; Chari, Suresh T.; Lai, Lisa A.; Eng, Jimmy K.; Brentnall, Teresa A.; Chen, Ru. 2020. "Systemic Proteome Alterations Linked to Early Stage Pancreatic Cancer in Diabetic Patients" Cancers 12, no. 6: 1534. https://doi.org/10.3390/cancers12061534

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop