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Article

Beneficial Molecular Adaptations in BRCA-Mutation Carriers by Combined HIT/HIRT Intervention: Results from a Pilot Study

1
Ulm University Hospital, Division of Sports and Rehabilitation Medicine, 89075 Ulm, Germany
2
Ulm University Hospital, Department of Gynecology and Obstetrics, 89075 Ulm, Germany
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Cancers 2020, 12(6), 1526; https://doi.org/10.3390/cancers12061526
Received: 27 April 2020 / Revised: 2 June 2020 / Accepted: 6 June 2020 / Published: 10 June 2020
(This article belongs to the Special Issue Molecular Genetics of Breast and Ovary Cancer)
Based on growing evidence that breast cancer (BRCA) also plays a pivotal role in the regulation of skeletal muscle metabolism and the response to anti-oxidative stress, we examined the influence of regular exercise in human BRCA mutation carriers on their BRCA1 gene/protein expression and inflammatory/oxidative response. Sixteen BRCA-mutation carriers were assigned to an intervention (IG) or control group (CG). IG received a combination of high-intensity interval endurance (HIT) and strength training (HIRT) for six weeks, whereas CG received a low-intensity activity program. Before (T0) and at the end of the intervention (T1), muscle biopsy, physiological performance, blood withdrawal and anthropometry were obtained. Parameters included: Muscle BRCA1 gene/protein expression, inflammatory/oxidative stress, anti-oxidative capacity, peak oxygen capacity (VO2peak) and 1-repetition maximum (1-RM) at six different training machines. VO2peak and 1-RM of IG were increased at T1 compared to T0, whereas CG performance, physiological and molecular parameters remained unchanged. IG showed increased BRCA1 protein concentration as well as anti-oxidative capacity, whereas gene expression was unaltered. IG inflammatory and oxidative damage did not differ between time points. Combined HIT/HIRT increases aerobic and strength performance of BRCA-mutation carriers with up regulated BRCA1 protein expression and improved anti-oxidative status without showing an increased inflammatory response. View Full-Text
Keywords: BRCA1 mutation; combination HIT/HIRT program; molecular adaptations; BRCA protein/gene expression; anti-oxidative stress/inflammatory response BRCA1 mutation; combination HIT/HIRT program; molecular adaptations; BRCA protein/gene expression; anti-oxidative stress/inflammatory response
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MDPI and ACS Style

Bizjak, D.A.; Schulz, S.V.W.; Schumann, U.; Otto, S.; Kirsten, J.; Ebner, F.; Leinert, E.; Huober, J.; Janni, W.; Steinacker, J.M. Beneficial Molecular Adaptations in BRCA-Mutation Carriers by Combined HIT/HIRT Intervention: Results from a Pilot Study. Cancers 2020, 12, 1526. https://doi.org/10.3390/cancers12061526

AMA Style

Bizjak DA, Schulz SVW, Schumann U, Otto S, Kirsten J, Ebner F, Leinert E, Huober J, Janni W, Steinacker JM. Beneficial Molecular Adaptations in BRCA-Mutation Carriers by Combined HIT/HIRT Intervention: Results from a Pilot Study. Cancers. 2020; 12(6):1526. https://doi.org/10.3390/cancers12061526

Chicago/Turabian Style

Bizjak, Daniel A., Sebastian V.W. Schulz, Uwe Schumann, Stephanie Otto, Johannes Kirsten, Florian Ebner, Elena Leinert, Jens Huober, Wolfgang Janni, and Jürgen M. Steinacker. 2020. "Beneficial Molecular Adaptations in BRCA-Mutation Carriers by Combined HIT/HIRT Intervention: Results from a Pilot Study" Cancers 12, no. 6: 1526. https://doi.org/10.3390/cancers12061526

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