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Open AccessArticle

Beneficial Molecular Adaptations in BRCA-Mutation Carriers by Combined HIT/HIRT Intervention: Results from a Pilot Study

1
Ulm University Hospital, Division of Sports and Rehabilitation Medicine, 89075 Ulm, Germany
2
Ulm University Hospital, Department of Gynecology and Obstetrics, 89075 Ulm, Germany
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Cancers 2020, 12(6), 1526; https://doi.org/10.3390/cancers12061526
Received: 27 April 2020 / Revised: 2 June 2020 / Accepted: 6 June 2020 / Published: 10 June 2020
(This article belongs to the Special Issue Molecular Genetics of Breast and Ovary Cancer)
Based on growing evidence that breast cancer (BRCA) also plays a pivotal role in the regulation of skeletal muscle metabolism and the response to anti-oxidative stress, we examined the influence of regular exercise in human BRCA mutation carriers on their BRCA1 gene/protein expression and inflammatory/oxidative response. Sixteen BRCA-mutation carriers were assigned to an intervention (IG) or control group (CG). IG received a combination of high-intensity interval endurance (HIT) and strength training (HIRT) for six weeks, whereas CG received a low-intensity activity program. Before (T0) and at the end of the intervention (T1), muscle biopsy, physiological performance, blood withdrawal and anthropometry were obtained. Parameters included: Muscle BRCA1 gene/protein expression, inflammatory/oxidative stress, anti-oxidative capacity, peak oxygen capacity (VO2peak) and 1-repetition maximum (1-RM) at six different training machines. VO2peak and 1-RM of IG were increased at T1 compared to T0, whereas CG performance, physiological and molecular parameters remained unchanged. IG showed increased BRCA1 protein concentration as well as anti-oxidative capacity, whereas gene expression was unaltered. IG inflammatory and oxidative damage did not differ between time points. Combined HIT/HIRT increases aerobic and strength performance of BRCA-mutation carriers with up regulated BRCA1 protein expression and improved anti-oxidative status without showing an increased inflammatory response. View Full-Text
Keywords: BRCA1 mutation; combination HIT/HIRT program; molecular adaptations; BRCA protein/gene expression; anti-oxidative stress/inflammatory response BRCA1 mutation; combination HIT/HIRT program; molecular adaptations; BRCA protein/gene expression; anti-oxidative stress/inflammatory response
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MDPI and ACS Style

Bizjak, D.A.; Schulz, S.V.W.; Schumann, U.; Otto, S.; Kirsten, J.; Ebner, F.; Leinert, E.; Huober, J.; Janni, W.; Steinacker, J.M. Beneficial Molecular Adaptations in BRCA-Mutation Carriers by Combined HIT/HIRT Intervention: Results from a Pilot Study. Cancers 2020, 12, 1526. https://doi.org/10.3390/cancers12061526

AMA Style

Bizjak DA, Schulz SVW, Schumann U, Otto S, Kirsten J, Ebner F, Leinert E, Huober J, Janni W, Steinacker JM. Beneficial Molecular Adaptations in BRCA-Mutation Carriers by Combined HIT/HIRT Intervention: Results from a Pilot Study. Cancers. 2020; 12(6):1526. https://doi.org/10.3390/cancers12061526

Chicago/Turabian Style

Bizjak, Daniel A.; Schulz, Sebastian V.W.; Schumann, Uwe; Otto, Stephanie; Kirsten, Johannes; Ebner, Florian; Leinert, Elena; Huober, Jens; Janni, Wolfgang; Steinacker, Jürgen M. 2020. "Beneficial Molecular Adaptations in BRCA-Mutation Carriers by Combined HIT/HIRT Intervention: Results from a Pilot Study" Cancers 12, no. 6: 1526. https://doi.org/10.3390/cancers12061526

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