Association between Abdominal Obesity and Incident Colorectal Cancer: A Nationwide Cohort Study in Korea

Nam, Ga Eun; Baek, Se-Jin; Choi, Hong Bae; Han, Kyungdo; Kwak, Jung-Myun; Kim, Jin; Kim, Seon-Hahn

doi:10.3390/cancers12061368

Open AccessArticle

Association between Abdominal Obesity and Incident Colorectal Cancer: A Nationwide Cohort Study in Korea

by

Ga Eun Nam

^1,†,

Se-Jin Baek

^2,†

,

Hong Bae Choi

²,

Kyungdo Han

³,

Jung-Myun Kwak

²

,

Jin Kim

^2,*

and

Seon-Hahn Kim

²

¹

Department of Family Medicine, College of Medicine, Korea University, Seoul 02841, Korea

²

Department of Surgery, College of Medicine, Korea University, Seoul 02841, Korea

³

Department of Statistics and Actuarial Science, Soongsil University, Seoul 06978, Korea

^*

Author to whom correspondence should be addressed.

^†

These authors contributed equally to this paper.

Cancers 2020, 12(6), 1368; https://doi.org/10.3390/cancers12061368

Submission received: 20 April 2020 / Revised: 21 May 2020 / Accepted: 23 May 2020 / Published: 26 May 2020

(This article belongs to the Special Issue ~~How~~ Does Obesity Cause Cancer?)

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Abstract

Background: We investigated the association of w May aist circumference (WC) and abdominal obesity with the incident colorectal cancer risk in Korean adults. Methods: This nationwide population-based cohort study was based on health insurance claims data. We analyzed data from 9,959,605 participants acquired through health check-ups of the Korean National Health Insurance Service in 2009 who were followed up until the end of 2017. We performed multivariable Cox proportional hazards regression analysis. Results: During 8.3 years of follow up, 101,197 cases (1.0%) of colorectal cancer were recorded. After adjusting for potential confounders, there was a positive association between WC and colorectal cancer risk (p for trend <0.001). Abdominal obesity was associated with an increased risk of colorectal (hazard ratio: 1.10, (95% confidence interval: 1.08–1.12)), colon (1.11, 1.09–1.13), and rectal cancer (1.08, 1.05–1.10). These associations were independent of body mass index and were more pronounced in men and elderly individuals. Conclusion: We revealed that higher WC is related to colorectal cancer risk, thus suggesting that abdominal obesity may be a risk factor for colorectal cancer in this East Asian population.

Keywords: abdominal obesity; waist circumference; colorectal neoplasm; body mass index

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MDPI and ACS Style

Nam, G.E.; Baek, S.-J.; Choi, H.B.; Han, K.; Kwak, J.-M.; Kim, J.; Kim, S.-H. Association between Abdominal Obesity and Incident Colorectal Cancer: A Nationwide Cohort Study in Korea. Cancers 2020, 12, 1368. https://doi.org/10.3390/cancers12061368

AMA Style

Nam GE, Baek S-J, Choi HB, Han K, Kwak J-M, Kim J, Kim S-H. Association between Abdominal Obesity and Incident Colorectal Cancer: A Nationwide Cohort Study in Korea. Cancers. 2020; 12(6):1368. https://doi.org/10.3390/cancers12061368

Chicago/Turabian Style

Nam, Ga Eun, Se-Jin Baek, Hong Bae Choi, Kyungdo Han, Jung-Myun Kwak, Jin Kim, and Seon-Hahn Kim. 2020. "Association between Abdominal Obesity and Incident Colorectal Cancer: A Nationwide Cohort Study in Korea" Cancers 12, no. 6: 1368. https://doi.org/10.3390/cancers12061368

APA Style

Nam, G. E., Baek, S.-J., Choi, H. B., Han, K., Kwak, J.-M., Kim, J., & Kim, S.-H. (2020). Association between Abdominal Obesity and Incident Colorectal Cancer: A Nationwide Cohort Study in Korea. Cancers, 12(6), 1368. https://doi.org/10.3390/cancers12061368

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Association between Abdominal Obesity and Incident Colorectal Cancer: A Nationwide Cohort Study in Korea

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