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Open AccessArticle

Detecting Endometrial Cancer by Blood Spectroscopy: A Diagnostic Cross-Sectional Study

1
School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston PR1 2HE, UK
2
Department of Metabolism, Institute of Reproductive and Developmental Biology, Digestion and Reproduction & Surgery and Cancer, Imperial College London, London W12 0HS, UK
3
Pathology Department, Lancashire Teaching Hospitals NHS Foundation, Preston PR2 9HT, UK
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Pathology Department, Manchester University Hospitals NHS Foundation Trust, Manchester M13 9WL, UK
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Division of Cancer Sciences, University of Manchester, Manchester M13 9WL, UK
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Department of Obstetrics and Gynaecology, Manchester University Hospitals NHS Foundation Trust, Manchester M13 9WL, UK
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Department of Chemistry, Biological Chemistry and Chemometrics, Federal University of Rio Grande do Norte, Natal 59072-970, Brazil
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West London Gynaecological Cancer Centre, Queen Charlotte’s & Chelsea–Hammersmith Hospital, Imperial Healthcare NHS Trust, London W12 0HS, UK
9
Department of Obstetrics and Gynaecology, Lancashire Teaching Hospitals NHS Foundation, Preston PR2 9HT, UK
*
Author to whom correspondence should be addressed.
Joint Senior authors.
Cancers 2020, 12(5), 1256; https://doi.org/10.3390/cancers12051256
Received: 9 April 2020 / Revised: 7 May 2020 / Accepted: 12 May 2020 / Published: 16 May 2020
(This article belongs to the Special Issue Non-Invasive Early Detection of Cancers)
Endometrial cancer is the sixth most common cancer in women, with a rising incidence worldwide. Current approaches for the diagnosis and screening of endometrial cancer are invasive, expensive or of moderate diagnostic accuracy, limiting their clinical utility. There is a need for cost-effective and minimally invasive approaches to facilitate the early detection and timely management of endometrial cancer. We analysed blood plasma samples in a cross-sectional diagnostic accuracy study of women with endometrial cancer (n = 342), its precursor lesion atypical hyperplasia (n = 68) and healthy controls (n = 242, total n = 652) using attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy and machine learning algorithms. We show that blood-based infrared spectroscopy has the potential to detect endometrial cancer with 87% sensitivity and 78% specificity. Its accuracy is highest for Type I endometrial cancer, the most common subtype, and for atypical hyperplasia, with sensitivities of 91% and 100%, and specificities of 81% and 88%, respectively. Our large-cohort study shows that a simple blood test could enable the early detection of endometrial cancer of all stages in symptomatic women and provide the basis of a screening tool in high-risk groups. Such a test has the potential not only to differentially diagnose endometrial cancer but also to detect its precursor lesion atypical hyperplasia—the early recognition of which may allow fertility sparing management and cancer prevention. View Full-Text
Keywords: blood diagnostics; endometrial cancer; screening; spectroscopy blood diagnostics; endometrial cancer; screening; spectroscopy
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Paraskevaidi, M.; Morais, C.L.M.; Ashton, K.M.; Stringfellow, H.F.; McVey, R.J.; Ryan, N.A.J.; O’Flynn, H.; Sivalingam, V.N.; Kitson, S.J.; MacKintosh, M.L.; Derbyshire, A.E.; Pow, C.; Raglan, O.; Lima, K.M.G.; Kyrgiou, M.; Martin-Hirsch, P.L.; Martin, F.L.; Crosbie, E.J. Detecting Endometrial Cancer by Blood Spectroscopy: A Diagnostic Cross-Sectional Study. Cancers 2020, 12, 1256.

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