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Volume 12
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10.3390/cancers12051172
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Review

Inducing Angiogenesis, a Key Step in Cancer Vascularization, and Treatment Approaches

by
Harman Saman
1,2,*,
Syed Shadab Raza
3,
Shahab Uddin
4 and
Kakil Rasul
5
1
Barts Cancer Institute, Queen Mary University of London, London E1 4NS, UK
2
Department of Medicine, Hazm Maubrairek Hospital, Ar-Rayyan PO Box 305, Qatar
3
Department of Stem Cell Biology and Regenerative Medicine, ERA University, Lucknow 226003, India
4
Translational Research Institute, Academic Health System, Hamad Medical Corporation, Doha 3050, Qatar
5
National Cancer Care and Research, Hamad Medical Corporation, Doha 3050, Qatar
*
Author to whom correspondence should be addressed.
Cancers 2020, 12(5), 1172; https://doi.org/10.3390/cancers12051172
Submission received: 23 February 2020 / Revised: 10 April 2020 / Accepted: 17 April 2020 / Published: 6 May 2020
(This article belongs to the Special Issue Angiogenesis in Cancers)
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Abstract

Angiogenesis is a term that describes the formation of new blood and lymphatic vessels from a pre-existing vasculature. This allows tumour cells to acquire sustenance in the form of nutrients and oxygen and the ability to evacuate metabolic waste. As one of the hallmarks of cancer, angiogenesis has been studied extensively in animal and human models to enable better understanding of cancer biology and the development of new anti-cancer treatments. Angiogenesis plays a crucial role in the process of tumour genesis, because solid tumour need a blood supply if they are to grow beyond a few millimeters in size. On the other hand, there is growing evidence that some solid tumour exploit existing normal blood supply and do not require a new vessel formation to grow and to undergo metastasis. This review of the literature will present the current understanding of this intricate process and the latest advances in the use of angiogenesis-targeting therapies in the fight against cancer.
Keywords: angiogenesis; cancer; VEGF; anticancer angiogenesis; cancer; VEGF; anticancer

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MDPI and ACS Style

Saman, H.; Raza, S.S.; Uddin, S.; Rasul, K. Inducing Angiogenesis, a Key Step in Cancer Vascularization, and Treatment Approaches. Cancers 2020, 12, 1172. https://doi.org/10.3390/cancers12051172

AMA Style

Saman H, Raza SS, Uddin S, Rasul K. Inducing Angiogenesis, a Key Step in Cancer Vascularization, and Treatment Approaches. Cancers. 2020; 12(5):1172. https://doi.org/10.3390/cancers12051172

Chicago/Turabian Style

Saman, Harman, Syed Shadab Raza, Shahab Uddin, and Kakil Rasul. 2020. "Inducing Angiogenesis, a Key Step in Cancer Vascularization, and Treatment Approaches" Cancers 12, no. 5: 1172. https://doi.org/10.3390/cancers12051172

APA Style

Saman, H., Raza, S. S., Uddin, S., & Rasul, K. (2020). Inducing Angiogenesis, a Key Step in Cancer Vascularization, and Treatment Approaches. Cancers, 12(5), 1172. https://doi.org/10.3390/cancers12051172

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