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Article

Increased Level of Long Non-Coding RNA MALAT1 Is a Common Feature of Amoeboid Invasion

1
Department of Cell Biology, Charles University, Viničná 7, 12843 Prague, Czech Republic
2
Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University (BIOCEV), Průmyslová 595, 25242 Vestec u Prahy, Czech Republic
3
Medical Faculty, Martin-Luther-University Halle-Wittenberg, Kurt-Mothes-Str. 3a, 06120 Halle (Saale), Germany
4
Department of Thoracic Surgery, Division of Cancer Research, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, German Cancer Consortium (DKTK)—Partner Site Freiburg, Breisacher Str. 115, 79106 Freiburg, Germany
5
Division of RNA Biology & Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
*
Author to whom correspondence should be addressed.
These authors contributed equally to the work.
Cancers 2020, 12(5), 1136; https://doi.org/10.3390/cancers12051136
Received: 18 March 2020 / Revised: 20 April 2020 / Accepted: 29 April 2020 / Published: 1 May 2020
The ability of cancer cells to adopt various migration modes (the plasticity of cancer cell invasiveness) is a substantive obstacle in the treatment of metastasis, yet still an incompletely understood process. We performed a comparison of publicly available transcriptomic datasets from various cell types undergoing a switch between the mesenchymal and amoeboid migration modes. Strikingly, lncRNA MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) was one of three genes that were found upregulated in all amoeboid cells analyzed. Accordingly, downregulation of MALAT1 in predominantly amoeboid cell lines A375m2 and A2058 resulted in decrease of active RhoA (Ras homolog family member A) and was accompanied by the amoeboid-mesenchymal transition in A375m2 cells. Moreover, MALAT1 downregulation in amoeboid cells led to increased cell proliferation. Our work is the first to address the role of MALAT1 in MAT/AMT (mesenchymal to amoeboid transition/amoeboid to mesenchymal transition) and suggests that increased MALAT1 expression is a common feature of amoeboid cells. View Full-Text
Keywords: MALAT1; lncRNA; cancer; amoeboid invasion; mesenchymal invasion; invasion plasticity; melanoma MALAT1; lncRNA; cancer; amoeboid invasion; mesenchymal invasion; invasion plasticity; melanoma
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MDPI and ACS Style

Merta, L.; Gandalovičová, A.; Čermák, V.; Dibus, M.; Gutschner, T.; Diederichs, S.; Rösel, D.; Brábek, J. Increased Level of Long Non-Coding RNA MALAT1 Is a Common Feature of Amoeboid Invasion. Cancers 2020, 12, 1136. https://doi.org/10.3390/cancers12051136

AMA Style

Merta L, Gandalovičová A, Čermák V, Dibus M, Gutschner T, Diederichs S, Rösel D, Brábek J. Increased Level of Long Non-Coding RNA MALAT1 Is a Common Feature of Amoeboid Invasion. Cancers. 2020; 12(5):1136. https://doi.org/10.3390/cancers12051136

Chicago/Turabian Style

Merta, Ladislav; Gandalovičová, Aneta; Čermák, Vladimír; Dibus, Michal; Gutschner, Tony; Diederichs, Sven; Rösel, Daniel; Brábek, Jan. 2020. "Increased Level of Long Non-Coding RNA MALAT1 Is a Common Feature of Amoeboid Invasion" Cancers 12, no. 5: 1136. https://doi.org/10.3390/cancers12051136

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