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Stress Management: Death Receptor Signalling and Cross-Talks with the Unfolded Protein Response in Cancer

by Elodie Lafont 1,2
1
Inserm U1242, Université de Rennes, 35042 Rennes, France
2
Centre de Lutte Contre le Cancer Eugène Marquis, 35042 Rennes, France
Cancers 2020, 12(5), 1113; https://doi.org/10.3390/cancers12051113
Received: 31 March 2020 / Revised: 20 April 2020 / Accepted: 23 April 2020 / Published: 29 April 2020
(This article belongs to the Special Issue Therapeutic Targeting of the Unfolded Protein Response in Cancer)
Throughout tumour progression, tumour cells are exposed to various intense cellular stress conditions owing to intrinsic and extrinsic cues, to which some cells are remarkably able to adapt. Death Receptor (DR) signalling and the Unfolded Protein Response (UPR) are two stress responses that both regulate a plethora of outcomes, ranging from proliferation, differentiation, migration, cytokine production to the induction of cell death. Both signallings are major modulators of physiological tissue homeostasis and their dysregulation is involved in tumorigenesis and the metastastic process. The molecular determinants of the control between the different cellular outcomes induced by DR signalling and the UPR in tumour cells and their stroma and their consequences on tumorigenesis are starting to be unravelled. Herein, I summarize the main steps of DR signalling in relation to its cellular and pathophysiological roles in cancer. I then highlight how the UPR and DR signalling control common cellular outcomes and also cross-talk, providing potential opportunities to further understand the development of malignancies. View Full-Text
Keywords: death receptor; ER stress; unfolded protein response; TRAIL-R1/2; CD95; TNFR1; post-translational modifications; cell death; IRE1; PERK death receptor; ER stress; unfolded protein response; TRAIL-R1/2; CD95; TNFR1; post-translational modifications; cell death; IRE1; PERK
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MDPI and ACS Style

Lafont, E. Stress Management: Death Receptor Signalling and Cross-Talks with the Unfolded Protein Response in Cancer. Cancers 2020, 12, 1113.

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