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Open AccessFeature PaperArticle

Post-Treatment HPV Surface Brushings and Risk of Relapse in Oropharyngeal Carcinoma

1
Department of Otorhinolaryngology, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
2
Division of Virology, Department of Hygiene, Microbiology, Social Medicine, Medical University of Innsbruck, Peter-Mayr-Strasse 4b, 6020 Innsbruck, Austria
3
Department of Radiology, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
*
Author to whom correspondence should be addressed.
Cancers 2020, 12(5), 1069; https://doi.org/10.3390/cancers12051069
Received: 27 March 2020 / Revised: 19 April 2020 / Accepted: 23 April 2020 / Published: 25 April 2020
(This article belongs to the Special Issue Human Papillomavirus and Cancers)
Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is a distinct subtype of head and neck cancer. Here, we investigated how frequently brushing remained high-risk (hr)-HPV positive after treatment and whether patients with positive post-treatment brushings have a higher recurrence rate. Following the end of treatment of patients with initially hr-HPV positive OPSCC, surface brushings from the previous tumor site were performed and tested for hr-HPV DNA. Of 62 patients with initially hr-HPV DNA-positive OPSCC, seven patients remained hr-HPV-DNA positive at post-treatment follow-up. Of the seven hr-HPV-positive patients at follow-up, five had a tumor relapse or tumor progression, of whom three died. The majority of patients (55/62) was HPV-negative following treatment. All HPV-negative patients remained free of disease (p = 0.0007). In this study, all patients with recurrence were hr-HPV-positive with the same genotype as that before treatment. In patients who were hr-HPV negative after treatment, no recurrence was observed. View Full-Text
Keywords: oropharyngeal squamous cell carcinoma; human papillomavirus; recurrence; surface brushing; EGFR oropharyngeal squamous cell carcinoma; human papillomavirus; recurrence; surface brushing; EGFR
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Kofler, B.; Borena, W.; Dudas, J.; Innerhofer, V.; Dejaco, D.; Steinbichler, T.B.; Widmann, G.; von Laer, D.; Riechelmann, H. Post-Treatment HPV Surface Brushings and Risk of Relapse in Oropharyngeal Carcinoma. Cancers 2020, 12, 1069.

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