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The Role of Circulating Tumor Cells in the Metastatic Cascade: Biology, Technical Challenges, and Clinical Relevance

1
Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz 51368, Iran
2
Student Research Committee, Tabriz University of Medical Sciences, Tabriz 51368, Iran
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Proteomics Research Center, Tabriz University of Medical Sciences, Tabriz 51368, Iran
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Laboratory of Rare Human Circulating Cells (LCCRH), University Medical Centre of Montpellier, UPRES, EA2415, 34093 Montpellier, France
5
Drug Applied Research Center, Tabriz University of Medical Sciences, 51368 Tabriz, Iran
*
Author to whom correspondence should be addressed.
Cancers 2020, 12(4), 867; https://doi.org/10.3390/cancers12040867
Received: 17 January 2020 / Revised: 28 March 2020 / Accepted: 30 March 2020 / Published: 3 April 2020
(This article belongs to the Special Issue Circulating Tumor Cells' Heterogeneity and Precision Oncology)
Metastases and cancer recurrence are the main causes of cancer death. Circulating Tumor Cells (CTCs) and disseminated tumor cells are the drivers of cancer cell dissemination. The assessment of CTCs’ clinical role in early metastasis prediction, diagnosis, and treatment requires more information about their biology, their roles in cancer dormancy, and immune evasion as well as in therapy resistance. Indeed, CTC functional and biochemical phenotypes have been only partially characterized using murine metastasis models and liquid biopsy in human patients. CTC detection, characterization, and enumeration represent a promising tool for tailoring the management of each patient with cancer. The comprehensive understanding of CTCs will provide more opportunities to determine their clinical utility. This review provides much-needed insights into this dynamic field of translational cancer research. View Full-Text
Keywords: circulating tumor cells; metastasis; cancer stem cells; dormancy; immune escape; therapy resistance; liquid biopsy circulating tumor cells; metastasis; cancer stem cells; dormancy; immune escape; therapy resistance; liquid biopsy
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MDPI and ACS Style

Dianat-Moghadam, H.; Azizi, M.; Eslami-S, Z.; Cortés-Hernández, L.E.; Heidarifard, M.; Nouri, M.; Alix-Panabières, C. The Role of Circulating Tumor Cells in the Metastatic Cascade: Biology, Technical Challenges, and Clinical Relevance. Cancers 2020, 12, 867. https://doi.org/10.3390/cancers12040867

AMA Style

Dianat-Moghadam H, Azizi M, Eslami-S Z, Cortés-Hernández LE, Heidarifard M, Nouri M, Alix-Panabières C. The Role of Circulating Tumor Cells in the Metastatic Cascade: Biology, Technical Challenges, and Clinical Relevance. Cancers. 2020; 12(4):867. https://doi.org/10.3390/cancers12040867

Chicago/Turabian Style

Dianat-Moghadam, Hassan, Mehdi Azizi, Zahra Eslami-S, Luis E. Cortés-Hernández, Maryam Heidarifard, Mohammad Nouri, and Catherine Alix-Panabières. 2020. "The Role of Circulating Tumor Cells in the Metastatic Cascade: Biology, Technical Challenges, and Clinical Relevance" Cancers 12, no. 4: 867. https://doi.org/10.3390/cancers12040867

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