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Contribution of mTOR and PTEN to Radioresistance in Sporadic and NF2-Associated Vestibular Schwannomas: A Microarray and Pathway Analysis
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Therapy of Sporadic and NF2-Related Vestibular Schwannoma

by Longping Yao 1,†, Mohammed Alahmari 1,2,†, Yasin Temel 1 and Koos Hovinga 1,*,†
1
Department of Neurosurgery, Maastricht University Medical Center, 6202 AZ Maastricht, The Netherlands
2
Department of Radiology, King Fahad Hospital of Imam Abdulrahman Bin Faisal University, P.O. Box 40046, 31952 AL-Khobar, Saudi Arabia
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Cancers 2020, 12(4), 835; https://doi.org/10.3390/cancers12040835
Received: 19 February 2020 / Revised: 29 March 2020 / Accepted: 30 March 2020 / Published: 31 March 2020
(This article belongs to the Special Issue New Insights into Neurofibromatosis)
Vestibular schwannoma (VS) is a benign primary brain tumor that occurs sporadic or as part of a genetic syndrome. The most common cause is the mutation of the NF2 tumor suppressor gene that is involved in the production of the protein merlin. Merlin plays a role in cell growth and cell adhesion. In patients with NF2, the VSs arise bilaterally and coincide with other brain tumors. In sporadic VS, the tumor is typically unilateral and does not coincide in combination with other tumors. MRI is the standard imaging technique and can be used to assess the size and aspect of the tumor as well as the progression of disease. The preferred management of large VS in both VS types is surgery with or without adjuvant radiation. The management for the medium- or small-sized VS includes wait and scan, radiotherapy and/or surgery. This choice depends on the preference of the patient and institutional protocols. The outcomes of surgical and radiotherapy treatments are improving due to progress in surgical equipment/approaches, advances in radiation delivery techniques and dose optimizations protocols. The main purpose of the management of VS is preserving function as long as possible in combination with tumor control. View Full-Text
Keywords: vestibular schwannoma; NF2; management; surgery; radiotherapy; function preservation and radiation-induced effects vestibular schwannoma; NF2; management; surgery; radiotherapy; function preservation and radiation-induced effects
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Yao, L.; Alahmari, M.; Temel, Y.; Hovinga, K. Therapy of Sporadic and NF2-Related Vestibular Schwannoma. Cancers 2020, 12, 835.

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