Overexpression of Canonical Prefoldin Associates with the Risk of Mortality and Metastasis in Non-Small Cell Lung Cancer
Abstract
1. Introduction
2. Methods and Materials
2.1. mRNA Expression
2.2. Patient Population
2.3. Tissue Microarrays Immunohistochemical Analysis
2.4. Statistical Analysis
3. Results
3.1. PFDN1 mRNA Levels Associates with OS in NSCLC
3.2. Association of PFDN and Survival in NSCLC Patients
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Characteristics | NO. of Patients (%) n = 58 |
---|---|
Gender | |
Female | 8 (14) |
Male | 50 (86) |
Age, years | |
Median (range) | 67 (41–82) |
Chronic obstructive pulmonary disease | |
No | 34 (59) |
Yes | 24 (41) |
Hypertension | |
No | 31 (53) |
Yes | 27 (57) |
Diabetes Mellitus | |
No | 42 (58) |
Yes | 16 (42) |
Dyslipidemia | |
No | 26 (45) |
Yes | 32 (55) |
Cardiovascular disease | |
No | 45 (78) |
Yes | 13 (22) |
Thrombosis | |
No | 49 (84) |
Yes | 9 (16) |
Smoking status | |
Never | 3 (5) |
Former | 28 (48) |
Current | 27 (47) |
History of alcohol consumption | |
No | 31 (53) |
Yes | 27 (47) |
Karnofsky Performance Status | |
100 | 13 (22) |
90 | 15 (26) |
80 | 16 (28) |
70 | 14 (24) |
Histology | |
Adenocarcinoma | 24 (41) |
Squamous | 34 (59) |
T stage | |
T1 | 13 (22) |
T2 | 28 (48) |
T3 | 11 (19) |
T4 | 6 (10) |
N stage | |
N0 | 19 (33) |
N1 | 8 (14) |
N2 | 25 (43) |
N3 | 6 (10) |
M stage | |
M0 | 53 (91) |
M1 | 5 (9) |
Stage | |
IA | 1 (2) |
IB | 13 (22) |
IIA | 4 (7) |
IIIA | 27 (47) |
IIIB | 8 (14) |
IV | 5 (9) |
Surgery | |
Yes | 52 (90) |
No | 6 (10) |
Thoracic radiation therapy * | |
Yes | 24 (41) |
No | 34 (59) |
Chemotherapy ** | |
Yes | 40 (69) |
No | 18 (31) |
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Peñate, X.; Praena-Fernández, J.M.; Romero Pareja, P.; Enguix-Riego, M.d.V.; Payán-Bravo, L.; Vieites, B.; Gomez-Izquierdo, L.; Jaen Olasolo, J.; Rivin del Campo, E.; Reyes, J.C.; et al. Overexpression of Canonical Prefoldin Associates with the Risk of Mortality and Metastasis in Non-Small Cell Lung Cancer. Cancers 2020, 12, 1052. https://doi.org/10.3390/cancers12041052
Peñate X, Praena-Fernández JM, Romero Pareja P, Enguix-Riego MdV, Payán-Bravo L, Vieites B, Gomez-Izquierdo L, Jaen Olasolo J, Rivin del Campo E, Reyes JC, et al. Overexpression of Canonical Prefoldin Associates with the Risk of Mortality and Metastasis in Non-Small Cell Lung Cancer. Cancers. 2020; 12(4):1052. https://doi.org/10.3390/cancers12041052
Chicago/Turabian StylePeñate, Xenia, Juan Manuel Praena-Fernández, Pedro Romero Pareja, María del Valle Enguix-Riego, Laura Payán-Bravo, Begoña Vieites, Lourdes Gomez-Izquierdo, Javier Jaen Olasolo, Eleonor Rivin del Campo, Jose Carlos Reyes, and et al. 2020. "Overexpression of Canonical Prefoldin Associates with the Risk of Mortality and Metastasis in Non-Small Cell Lung Cancer" Cancers 12, no. 4: 1052. https://doi.org/10.3390/cancers12041052
APA StylePeñate, X., Praena-Fernández, J. M., Romero Pareja, P., Enguix-Riego, M. d. V., Payán-Bravo, L., Vieites, B., Gomez-Izquierdo, L., Jaen Olasolo, J., Rivin del Campo, E., Reyes, J. C., Chávez, S., & Lopez Guerra, J. L. (2020). Overexpression of Canonical Prefoldin Associates with the Risk of Mortality and Metastasis in Non-Small Cell Lung Cancer. Cancers, 12(4), 1052. https://doi.org/10.3390/cancers12041052