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Renal Tumors of Childhood—A Histopathologic Pattern-Based Diagnostic Approach

Princess Máxima Center for pediatric oncology, 3584 CS Utrecht, The Netherlands
Pathan B.V., 3045 PM Rotterdam, The Netherlands
Department of Pathology, Sidra Medicine, Doha 0000, Qatar
Department of Pathology, Oslo University Hospital, Rikshospitalet, 0372 Oslo, Norway
Department of Diagnostic Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy
Sorbonne Université, Department of Pathology, Hôpital Armand Trousseau, Hopitaux Universitaires Est Parisien, 75012 Paris, France
Section of Pediatric Pathology, Department of Pathology, University Hospital Bonn, 53127 Bonn, Germany
Department of Pediatric Oncology & Hematology, Saarland University, D-66421 Homburg, Germany
Department of Pathology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
Author to whom correspondence should be addressed.
These authors contributed equally to this paper as first authors.
Cancers 2020, 12(3), 729;
Received: 2 February 2020 / Revised: 4 March 2020 / Accepted: 7 March 2020 / Published: 19 March 2020
(This article belongs to the Special Issue Pathogenesis and Diagnosis of Genitourinary Cancer)
Renal tumors comprise approximately 7% of all malignant pediatric tumors. This is a highly heterogeneous group of tumors, each with its own therapeutic management, outcome, and association with germline predispositions. Histopathology is the key in establishing the correct diagnosis, and therefore pathologists with expertise in pediatric oncology are needed for dealing with these rare tumors. While each tumor shows different histologic features, they do have considerable overlap in cell type and histologic pattern, making the diagnosis difficult to establish, if based on routine histology alone. To this end, ancillary techniques, such as immunohistochemistry and molecular analysis, can be of great importance for the correct diagnosis, resulting in appropriate treatment. To use ancillary techniques cost-effectively, we propose a pattern-based approach and provide recommendations to aid in deciding which panel of antibodies, supplemented by molecular characterization of a subset of genes, are required. View Full-Text
Keywords: pediatric; oncology; renal tumors; immunohistochemistry; molecular analysis pediatric; oncology; renal tumors; immunohistochemistry; molecular analysis
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MDPI and ACS Style

Ooms, A.H.A.G.; Vujanić, G.M.; D’Hooghe, E.; Collini, P.; L’Herminé-Coulomb, A.; Vokuhl, C.; Graf, N.; van den Heuvel-Eibrink, M.M.; de Krijger, R.R. Renal Tumors of Childhood—A Histopathologic Pattern-Based Diagnostic Approach. Cancers 2020, 12, 729.

AMA Style

Ooms AHAG, Vujanić GM, D’Hooghe E, Collini P, L’Herminé-Coulomb A, Vokuhl C, Graf N, van den Heuvel-Eibrink MM, de Krijger RR. Renal Tumors of Childhood—A Histopathologic Pattern-Based Diagnostic Approach. Cancers. 2020; 12(3):729.

Chicago/Turabian Style

Ooms, Ariadne H.A.G., Gordan M. Vujanić, Ellen D’Hooghe, Paola Collini, Aurore L’Herminé-Coulomb, Christian Vokuhl, Norbert Graf, Marry M. van den Heuvel-Eibrink, and Ronald R. de Krijger. 2020. "Renal Tumors of Childhood—A Histopathologic Pattern-Based Diagnostic Approach" Cancers 12, no. 3: 729.

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