Tumor Suppressors in Chronic Lymphocytic Leukemia: From Lost Partners to Active Targets
Abstract
:1. Introduction
2. Mechanisms of Tumor Suppressor Inactivation in CLL: Genetic Loss of Function
2.1. Deletion of 13q14 Locus
2.2. TP53
2.3. ATM/del(11q)
2.4. SF3B1 Mutations
2.5. RPS15 Mutations
2.6. BIRC3 Mutations
2.7. NFKBIE Mutations
2.8. POT1 Mutations
2.9. RARRES3 Deletion
2.10. Rare Events
3. Mechanisms of Tumor Suppressor Inactivation in CLL: Functional Inactivation through Post-Translational Mechanisms
3.1. PTEN
3.2. p53
3.3. Puma
4. Mechanisms of Tumor Suppressor Inactivation in CLL: Epigenetic
4.1. Promoters’ Hypermethylation
4.2. Intronic Polyadenylation
5. Mechanisms of Tumor Suppressor Inactivation in CLL: MicroRNA (miRNA), Long Non-Coding RNA (lncRNA), and CircularRNA
5.1. miRNA
5.2. LncRNAs
5.3. CircRNAs
6. Therapeutic Implications
7. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Andreani, G.; Carrà, G.; Lingua, M.F.; Maffeo, B.; Brancaccio, M.; Taulli, R.; Morotti, A. Tumor Suppressors in Chronic Lymphocytic Leukemia: From Lost Partners to Active Targets. Cancers 2020, 12, 629. https://doi.org/10.3390/cancers12030629
Andreani G, Carrà G, Lingua MF, Maffeo B, Brancaccio M, Taulli R, Morotti A. Tumor Suppressors in Chronic Lymphocytic Leukemia: From Lost Partners to Active Targets. Cancers. 2020; 12(3):629. https://doi.org/10.3390/cancers12030629
Chicago/Turabian StyleAndreani, Giacomo, Giovanna Carrà, Marcello Francesco Lingua, Beatrice Maffeo, Mara Brancaccio, Riccardo Taulli, and Alessandro Morotti. 2020. "Tumor Suppressors in Chronic Lymphocytic Leukemia: From Lost Partners to Active Targets" Cancers 12, no. 3: 629. https://doi.org/10.3390/cancers12030629
APA StyleAndreani, G., Carrà, G., Lingua, M. F., Maffeo, B., Brancaccio, M., Taulli, R., & Morotti, A. (2020). Tumor Suppressors in Chronic Lymphocytic Leukemia: From Lost Partners to Active Targets. Cancers, 12(3), 629. https://doi.org/10.3390/cancers12030629