Changes in Functional Outcome and Quality of Life in Soft Tissue Sarcoma Patients within the First Year after Surgery: A Prospective Observational Study
Abstract
:1. Introduction
2. Results
2.1. Functional Outcome Measures
2.2. Distress Measures
2.3. Associations between Self-Reported Outcomes and Objective Measurements
3. Discussion
4. Materials and Methods
4.1. Study Population
4.2. Outcome Measures
4.3. Statistical Analyses
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Characteristics | Patients (n = 29) | Characteristics | Patients (n = 29) |
---|---|---|---|
Age (in years + SD) | 63 ± 17.1 | Tumor grade (n, %) | |
Range in age | 25–86 | Grade 1 | 4 (14%) |
Gender (n, %) | Grade 2 | 11 (38%) | |
Male | 15 (52%) | Grade 3 | 14 (48%) |
Female | 14 (48%) | Tumor margin (n, %) | |
Location (n, %) | Wide | 24 (83%) | |
Upper extremity | 8 (28%) | Marginal | 5 (17%) |
Lower extremity | 21 (72%) | Adjuvant treatment (n, %) | |
Tumor size (in cm + SD) | 8.85 ± 4.81 | None | 17 (59%) |
Range in size | 1–18 | Radiotherapy (RT) | 11 (38%) |
Tumor depth (n, %) | RT + chemotherapy | 1 (3%) | |
Subcutaneous | 13 (45%) | ||
Subfascial | 16 (55%) |
Method | Before Surgery | 1 Month after Surgery | 2 Months after Surgery | 3 Months after Surgery | 1 Year after Surgery |
---|---|---|---|---|---|
No. (%) | No. (%) | No. (%) | No. (%) | No. (%) | |
Objective measurements | 28/29 (97%) | 15/29 (52%) | N/A | 19/27 (66%) | 13/24 (45%) |
Questionnaires | 28/29 (97%) | 20/29 (69%) | 25/29 (86%) | 24/27 (83%) | 16/24 (55%) |
Method | Score Range | Before Surgery (Baseline) | 1 Month after Surgery (MSTS Baseline) | 2 Months after Surgery | 3 Months after Surgery | 1 Year after Surgery | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Median | IQR | Median | IQR | p | Median | IQR | p | Median | IQR | p | Median | IQR | p | ||
TESS | 0–100 | 96.5 | 88–100 | 78.5 | 57–93.5 | <0.01 * | 88 | 77–94 | 0.01 * | 94 | 83.5–100 | 0.26 | 88 | 76–97.5 | 0.08 |
MSTS | 0–100 | N/A | N/A | 76.5 | 51.5–95 | N/A | N/A | N/A | N/A | 97 | 85–100 | 0.03 * | 93 | 80–100 | 0.11 |
WHO-5 well-being | 0–100 | 70 | 42–92 | 68 | 54–74 | 0.36 | 76 | 64–84 | 0.63 | 74 | 56–96 | 0.47 | 80 | 68–92 | 0.24 |
HADS | |||||||||||||||
Anxiety score | 0–21 | 5 | 3–7.5 | 4 | 1–5 | 0.12 | 2 | 0–5 | 0.03* | 2 | 0.5–5 | 0.03* | 2 | 1–5 | 0.03 * |
Depression score | 0–21 | 1 | 0–3 | 1 | 0–3 | 0.72 | 1 | 0–2 | 0.44 | 1 | 0–2 | 0.50 | 1 | 0–1 | 0.52 |
ISI | 0–28 | 7 | 3–13 | 7 | 4–9 | 0.80 | 3 | 2–9 | 0.21 | 6 | 1–10 | 0.46 | 3.5 | 0.5–10 | 0.19 |
MFI-20 | |||||||||||||||
General fatigue score | 4–20 | 9 | 5.5–12.5 | 10.5 | 8–12 | 0.31 | 8 | 6–12 | 0.84 | 7 | 4.5–14.5 | 0.94 | 10 | 4.5–11.5 | 0.96 |
Physical fatigue score | 4–20 | 8 | 6.5–13 | 13 | 11–18 | <0.01 * | 13 | 10–14 | 0.01 * | 10 | 7.5–14.5 | 0.36 | 10 | 7–14.5 | 0.35 |
Mental fatigue score | 4–20 | 8 | 4.5–11.5 | 7 | 5–9.5 | 0.63 | 6 | 4–9 | 0.22 | 6 | 4–8.5 | 0.33 | 6.5 | 4–9 | 0.28 |
Reduced activity score | 4–20 | 9 | 4.5–13 | 11 | 9.5–13.5 | 0.07 | 10 | 8–13 | 0.30 | 9 | 6–12 | 0.82 | 9 | 5.5–10.5 | 0.73 |
Reduced motivation score | 4–20 | 6.5 | 4–11.5 | 7 | 4.5–10 | 0.83 | 7 | 5–10 | 0.59 | 6 | 4.5–10.5 | 0.78 | 5 | 4–9 | 0.52 |
Method | Before Surgery | 1 Month after Surgery | 3 Months after Surgery | 1 Year after Surgery | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean | 95% CI | p | Mean | 95% CI | p | Mean | 95% CI | p | Mean | 95% CI | p | |
Isokinetic dynamometer 1 | ||||||||||||
Healthy side | 80.27 | 73.46–87.09 | 0.60 | 83.06 | 75.16–90.96 | <0.01 * | 81.59 | 71.96–91.21 | 0.04 * | 85.04 | 73.14–96.95 | 0.05 * |
Disease-affected side | 79.17 | 71.80–86.53 | 69.44 | 59.02–79.87 | 75.05 | 66.86–83.25 | 78.56 | 68.80–88.33 | ||||
Total average strength | 79.72 | 72.96–86.48 | 76.25 | 67.78–84.72 | 78.32 | 69.94–86.70 | 81.80 | 71.42–92.19 | ||||
10-MWT (m/s) | 2.12 | 1.91–2.34 | Baseline | 1.68 | 1.29–2.07 | 0.02 * | 1.95 | 1.75–2.16 | 0.24 | 2.08 | 1.66–2.49 | 0.80 |
9-HPT (seconds) | ||||||||||||
Healthy side | 20.85 | 16.98–24.73 | 0.08 | 22.46 | 17.03–27.89 | 0.74 | 21.37 | 15.96–26.78 | 0.81 | 21.70 | 12.97–30.43 | 0.86 |
Disease-affected side | 22.06 | 18.88–25.25 | 21.91 | 19.12–24.70 | 21.05 | 18.42–23.68 | 21.55 | 9.52–33.57 |
Method | Before Surgery(Baseline) | 1 Month after Surgery | 3 Months after Surgery | 1 Year after Surgery | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Median | IQR | Median | IQR | p | Median | IQR | p | Median | IQR | p | |
6-MWT: | 88.70 | 80.53–94.21 | 81.25 | 56.25–92.52 | 0.20 | 84.31 | 76.41–92.25 | 0.26 | 91.70 | 82.76–98.26 | 0.43 |
Method | Isokinetic Dynamometer | 10-MWT (LE) | 9-HPT (UE) | 6-MWT | ||||
---|---|---|---|---|---|---|---|---|
β | p | β | p | β | p | β | p | |
TESS | 0.24 | <0.01 * | 13.09 | <0.01 * | 0.68 | 0.39 | 0.05 | 0.44 |
MSTS | 0.24 | 0.17 | 28.80 | <0.01 * | 1.11 | 0.03 * | 0.14 | 0.22 |
WHO-5 well-being | 0.31 | 0.07 | 6.58 | 0.34 | 2.39 | 0.20 | 0.17 | 0.16 |
HADS | ||||||||
Anxiety score | −0.01 | 0.89 | 0.75 | 0.43 | −0.60 | 0.02 * | 0.01 | 0.80 |
Depression score | −0.04 | 0.06 | −0.08 | 0.91 | 0.03 | 0.91 | −0.03 | 0.02 * |
ISI | −0.04 | 0.35 | −0.03 | 0.99 | −0.73 | 0.08 | 0.01 | 0.72 |
MFI-20 | ||||||||
General fatigue score | −0.07 | 0.01 * | −2.16 | 0.05 * | −0.54 | 0.09 | −0.05 | 0.01 * |
Physical fatigue score | −0.13 | <0.01 * | −3.00 | 0.01 * | 0.01 | 0.99 | −0.07 | <0.01 * |
Mental fatigue score | −0.03 | 0.18 | 0.51 | 0.55 | −0.37 | 0.19 | −0.02 | 0.28 |
Reduced activity score | −0.10 | <0.01 * | −2.72 | 0.02 * | −0.32 | 0.27 | −0.04 | 0.06 |
Reduced motivation score | −0.08 | <0.01 * | −0.83 | 0.36 | −0.32 | 0.23 | −0.04 | 0.01 * |
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Saebye, C.; Amidi, A.; Keller, J.; Andersen, H.; Baad-Hansen, T. Changes in Functional Outcome and Quality of Life in Soft Tissue Sarcoma Patients within the First Year after Surgery: A Prospective Observational Study. Cancers 2020, 12, 463. https://doi.org/10.3390/cancers12020463
Saebye C, Amidi A, Keller J, Andersen H, Baad-Hansen T. Changes in Functional Outcome and Quality of Life in Soft Tissue Sarcoma Patients within the First Year after Surgery: A Prospective Observational Study. Cancers. 2020; 12(2):463. https://doi.org/10.3390/cancers12020463
Chicago/Turabian StyleSaebye, Casper, Ali Amidi, Johnny Keller, Henning Andersen, and Thomas Baad-Hansen. 2020. "Changes in Functional Outcome and Quality of Life in Soft Tissue Sarcoma Patients within the First Year after Surgery: A Prospective Observational Study" Cancers 12, no. 2: 463. https://doi.org/10.3390/cancers12020463