NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal Models

McDonald, J. Tyson; Stainforth, Robert; Miller, Jack; Cahill, Thomas; Silveira, Willian A. da; Rathi, Komal S.; Hardiman, Gary; Taylor, Deanne; Costes, Sylvain V.; Chauhan, Vinita; Meller, Robert; Beheshti, Afshin

doi:10.3390/cancers12020381

Submit to this Journal Review for this Journal Edit a Special Issue

Article Menu

...

Open AccessArticle

NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal Models

¹,

²,

⁴

Willian A. da Silveira

⁴

⁵,

^4,6

^5,7,8

⁹

²,

¹⁰ and

^3,*

RadBioX Services LLC, Okemos, MI 48864, USA

Consumer and Clinical Radiation Protection Bureau, Health Canada, Ottawa, ON K1A-1C1, Canada

KBR, NASA Ames Research Center, Moffett Field, CA 94035, USA

⁴

School of Biological Sciences & Institute for Global Food Security, Queens University Belfast, Belfast BT9 5DL, UK

⁵

Department of Biomedical Informatics, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA

⁶

Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA

⁷

The Center for Mitochondrial and Epigenomic Medicine, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA

⁸

The Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

⁹

NASA Ames Research Center, Space Biosciences Division, Moffett Field, CA 94035, USA

¹⁰

Department of Neurobiology and Pharmacology, Morehouse School of Medicine, Atlanta, GA 30310, USA

Author to whom correspondence should be addressed.

Cancers 2020, 12(2), 381; https://doi.org/10.3390/cancers12020381

Received: 19 January 2020 / Revised: 3 February 2020 / Accepted: 3 February 2020 / Published: 7 February 2020

(This article belongs to the Special Issue Animal Models for Radiotherapy Research)

View Full-Text Download PDF

Browse Figures

Review Reports Citation Export

Abstract

Background: Ionizing radiation from galactic cosmic rays (GCR) is one of the major risk factors that will impact the health of astronauts on extended missions outside the protective effects of the Earth’s magnetic field. The NASA GeneLab project has detailed information on radiation exposure using animal models with curated dosimetry information for spaceflight experiments. Methods: We analyzed multiple GeneLab omics datasets associated with both ground-based and spaceflight radiation studies that included in vivo and in vitro approaches. A range of ions from protons to iron particles with doses from 0.1 to 1.0 Gy for ground studies, as well as samples flown in low Earth orbit (LEO) with total doses of 1.0 mGy to 30 mGy, were utilized. Results: From this analysis, we were able to identify distinct biological signatures associating specific ions with specific biological responses due to radiation exposure in space. For example, we discovered changes in mitochondrial function, ribosomal assembly, and immune pathways as a function of dose. Conclusions: We provided a summary of how the GeneLab’s rich database of omics experiments with animal models can be used to generate novel hypotheses to better understand human health risks from GCR exposures. View Full-Text

Keywords: GeneLab; NASA; space radiation; HZE; galactic cosmic rays; transcriptomics; dosimetry; radiation

▼ Show Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Supplementary Material

Supplementary File 1:
ZIP-Document (ZIP, 1920 KiB)

Share and Cite

MDPI and ACS Style

McDonald, J.T.; Stainforth, R.; Miller, J.; Cahill, T.; Silveira, W.A.d.; Rathi, K.S.; Hardiman, G.; Taylor, D.; Costes, S.V.; Chauhan, V.; Meller, R.; Beheshti, A. NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal Models. Cancers 2020, 12, 381. https://doi.org/10.3390/cancers12020381

AMA Style

McDonald JT, Stainforth R, Miller J, Cahill T, Silveira WAd, Rathi KS, Hardiman G, Taylor D, Costes SV, Chauhan V, Meller R, Beheshti A. NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal Models. Cancers. 2020; 12(2):381. https://doi.org/10.3390/cancers12020381

Chicago/Turabian Style

McDonald, J. T., Robert Stainforth, Jack Miller, Thomas Cahill, Willian A.d. Silveira, Komal S. Rathi, Gary Hardiman, Deanne Taylor, Sylvain V. Costes, Vinita Chauhan, Robert Meller, and Afshin Beheshti. 2020. "NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal Models" Cancers 12, no. 2: 381. https://doi.org/10.3390/cancers12020381

Find Other Styles

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Abstract views Pdf views Html views

Article Menu

NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal Models

Abstract

Supplementary Material

Share and Cite

Article Metrics

Article Access Statistics

Article Access Map by Country/Region

Further Information

Guidelines

MDPI Initiatives

Follow MDPI