Genomic Fabric Remodeling in Metastatic Clear Cell Renal Cell Carcinoma (ccRCC): A New Paradigm and Proposal for a Personalized Gene Therapy Approach
Abstract
:Simple Summary
Abstract
1. Introduction
2. Results
2.1. Independent Characteristics of the Quantified Genes in Each Profiled Region
2.2. Transcriptomic Differences between Cancer Nodules
2.3. Regulation of the ccRCC Functional Pathway
2.4. Regulation of the Apoptosis Pathway
2.5. Regulation of the VEGF Signaling Pathway
2.6. Alteration of the Homeostatic Mechanisms That Control the Transcript Abundances
2.7. Changes in Gene Networking
2.8. Changes of the Transcriptomic Landscapes and Genomic Fabrics Interplay
2.9. Gene Hierarchies and Gene Master Regulators
2.10. GMR at Work
3. Discussion
4. Materials and Methods
4.1. Gene Expression Data
4.2. Average Expression Level (AVE)
4.3. Relative Expression Variability
4.4. Expression Coordination
4.5. Expression Regulation
4.6. Transcriptomic Separation
4.7. Pair-Wise Relevance
4.8. Gene Commanding Height (GCH) and Identification of Gene Master Regulator (GMR)
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Iacobas, D.A.; Mgbemena, V.E.; Iacobas, S.; Menezes, K.M.; Wang, H.; Saganti, P.B. Genomic Fabric Remodeling in Metastatic Clear Cell Renal Cell Carcinoma (ccRCC): A New Paradigm and Proposal for a Personalized Gene Therapy Approach. Cancers 2020, 12, 3678. https://doi.org/10.3390/cancers12123678
Iacobas DA, Mgbemena VE, Iacobas S, Menezes KM, Wang H, Saganti PB. Genomic Fabric Remodeling in Metastatic Clear Cell Renal Cell Carcinoma (ccRCC): A New Paradigm and Proposal for a Personalized Gene Therapy Approach. Cancers. 2020; 12(12):3678. https://doi.org/10.3390/cancers12123678
Chicago/Turabian StyleIacobas, Dumitru A., Victoria E. Mgbemena, Sanda Iacobas, Kareena M. Menezes, Huichen Wang, and Premkumar B. Saganti. 2020. "Genomic Fabric Remodeling in Metastatic Clear Cell Renal Cell Carcinoma (ccRCC): A New Paradigm and Proposal for a Personalized Gene Therapy Approach" Cancers 12, no. 12: 3678. https://doi.org/10.3390/cancers12123678