Global Autozygosity Is Associated with Cancer Risk, Mutational Signature and Prognosis
Abstract
:Simple Summary
Abstract
1. Introduction
2. Results
2.1. HRNonRef vs. HRMinor vs. ROH
2.2. Global Autozygosity and Cancer Risk
2.3. Mutational Signatures and Survival Analysis
3. Discussion
4. Materials and Methods
4.1. Genotyping Data Acquisition and Imputation
4.2. Somatic Mutation Data Acquisition and Mutational Signature Computation
4.3. HR and ROH Computation
4.4. Statistical Analyses
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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LogOR 1 (95% CI) | p | Cancer 2 | Race | Gender | Cases | Controls 3 |
---|---|---|---|---|---|---|
1.8973 (1.6228–2.1920) | 4.89 × 10−28 | BRCA | Black | female | 163 | 342 |
1.1487 (0.8858–1.4336) | 5.28 × 10−12 | SKCM | Caucasian | male | 274 | 240 |
0.9630 (0.7327–1.2104) | 3.34 × 10−11 | OV | Caucasian | female | 369 | 263 |
1.4445 (1.0980–1.8303) | 8.83 × 10−11 | STAD | Caucasian | male | 153 | 240 |
1.1018 (0.8318–1.3940) | 1.17 × 10−10 | BRCA | Caucasian | female | 653 | 263 |
1.1224 (0.8393–1.4289) | 3.80 × 10−10 | HNSC | Caucasian | male | 300 | 240 |
1.2666 (0.9249–1.6396) | 5.68 × 10−9 | LUAD | Caucasian | female | 165 | 263 |
0.9607 (0.6844–1.2734) | 7.93 × 10−8 | HNSC | Caucasian | female | 120 | 263 |
0.9216 (0.6325–1.2450) | 7.44 × 10−7 | PRAD | Caucasian | male | 127 | 240 |
0.8458 (0.5814–1.1452) | 7.70 × 10−7 | COAD | Caucasian | male | 101 | 240 |
0.6438 (0.4208–0.8882) | 6.00 × 10−6 | SKCM | Caucasian | female | 168 | 263 |
0.4797 (0.2712–0.7050) | 2.71 × 10−4 | LUAD | Caucasian | male | 134 | 240 |
0.4689 (0.2634–0.6977) | 3.82 × 10−4 | LUSC | Caucasian | male | 166 | 240 |
0.4903 (0.2585–0.7537) | 1.12 × 10−3 | LIHC | Asian | male | 118 | 244 |
LogOR 1 (95% CI) | p | Cancer 2 | Race | Gender | Cases | Controls 3 |
---|---|---|---|---|---|---|
15.6383 (7.9048–23.5950) | 0.0010 | COAD | Caucasian | male | 101 | 240 |
−0.2304 (−0.3658–−0.0969) | 0.0048 | OV | Caucasian | female | 369 | 263 |
5.3577 (2.2553–8.5218) | 0.0048 | PRAD | Caucasian | male | 127 | 240 |
−0.2839 (−0.4606–−0.1132) | 0.0071 | LUAD | Caucasian | female | 165 | 263 |
−0.1797 (−0.2989–−0.0623) | 0.0122 | BRCA | Caucasian | female | 653 | 263 |
−0.2557 (−0.4285–−0.0882) | 0.0133 | SKCM | Caucasian | female | 168 | 263 |
8.1083 (2.2387–14.1885) | 0.0253 | HNSC | Caucasian | male | 300 | 240 |
0.2548 (0.0708–0.4519) | 0.0269 | LIHC | Asian | male | 118 | 244 |
7.1487 (1.0826–13.0103) | 0.0422 | LUSC | Caucasian | male | 166 | 240 |
5.0918 (0.6647–9.4886) | 0.0483 | STAD | Caucasian | male | 153 | 240 |
−0.2022 (−0.3918–−0.0282) | 0.0670 | BRCA | Black | female | 163 | 342 |
−0.0873 (−0.2877–0.0971) | 0.4534 | HNSC | Caucasian | female | 120 | 263 |
0.7471 (−0.0236–2.9058) | 0.5483 | SKCM | Caucasian | male | 274 | 240 |
0.0625 (−0.1152–0.2397) | 0.5614 | LUAD | Caucasian | male | 134 | 240 |
Effect | Stderr 1 | Adusted p | Signature | Case | Predictor | Gender | Race | Cancer 2 |
---|---|---|---|---|---|---|---|---|
0.2638 | 0.0387 | 4.62 × 10−8 | SBS44 | 116 | ROH | female | Caucasian | HNSC |
0.3571 | 0.0679 | 3.02 × 10−5 | SBS36 | 125 | ROH | male | Caucasian | PRAD |
0.8407 | 0.1970 | 0.0013 | SBS9 | 277 | HRNonRef | female | Caucasian | OV |
1.3245 | 0.3223 | 0.0013 | SBS18 | 277 | HRNonRef | female | Caucasian | OV |
1.0001 | 0.2359 | 0.0018 | SBS42 | 164 | ROH | male | Caucasian | LUSC |
0.6597 | 0.1891 | 0.0070 | SBS5 | 277 | HRNonRef | female | Caucasian | OV |
0.8939 | 0.2564 | 0.0070 | SBS7c | 277 | HRNonRef | female | Caucasian | OV |
2.9086 | 0.7533 | 0.0172 | SBS7b | 132 | ROH | male | Caucasian | LUAD |
−0.0885 | 0.0234 | 0.0206 | SBS44 | 166 | HRNonRef | female | Caucasian | SKCM |
0.9714 | 0.3227 | 0.0280 | SBS22 | 277 | HRNonRef | female | Caucasian | OV |
0.2439 | 0.0718 | 0.0453 | SBS36 | 125 | HRNonRef | male | Caucasian | PRAD |
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Jiang, L.; Guo, F.; Tang, J.; Leng, S.; Ness, S.; Ye, F.; Kang, H.; Samuels, D.C.; Guo, Y. Global Autozygosity Is Associated with Cancer Risk, Mutational Signature and Prognosis. Cancers 2020, 12, 3646. https://doi.org/10.3390/cancers12123646
Jiang L, Guo F, Tang J, Leng S, Ness S, Ye F, Kang H, Samuels DC, Guo Y. Global Autozygosity Is Associated with Cancer Risk, Mutational Signature and Prognosis. Cancers. 2020; 12(12):3646. https://doi.org/10.3390/cancers12123646
Chicago/Turabian StyleJiang, Limin, Fei Guo, Jijun Tang, Shuguan Leng, Scott Ness, Fei Ye, Huining Kang, David C. Samuels, and Yan Guo. 2020. "Global Autozygosity Is Associated with Cancer Risk, Mutational Signature and Prognosis" Cancers 12, no. 12: 3646. https://doi.org/10.3390/cancers12123646