BRCA in Gastrointestinal Cancers: Current Treatments and Future Perspectives
Department of Oncology and Hematology, Division of Oncology, University of Modena and Reggio Emilia, 41121 Modena, Italy
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Cancers 2020, 12(11), 3346; https://doi.org/10.3390/cancers12113346
Received: 10 October 2020 / Revised: 26 October 2020 / Accepted: 11 November 2020 / Published: 12 November 2020
Simple Summary
BRCA gene mutations are progressively gaining more attention in the context of gastrointestinal malignancies, especially in pancreatic cancer where their identification can have both therapeutic and surveillance relevance.
A strong association between pancreatic cancer and BRCA1 and BRCA2 mutations is documented. Based on promising results of breast and ovarian cancers, several clinical trials with poly (ADP-ribose) polymerase inhibitors (PARPi) are ongoing for gastrointestinal (GI) malignancies, especially for pancreatic cancer. Indeed, the POLO trial results provide promising and awaited changes for the pancreatic cancer therapeutic landscape. Contrariwise, for other gastrointestinal tumors, the rationale is currently only alleged. The role of BRCA mutation in gastrointestinal cancers is the subject of this review. In particular, we aim to provide the latest updates about novel therapeutic strategies that, exploiting DNA repair defects, promise to shape the future therapeutic scenario of GI cancers.
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Keywords:
BRCA1; BRCA2; gastrointestinal cancers; HRD; pancreatic cancer; Olaparib; PARP inhibitors; surveillance
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Molinaro, E.; Andrikou, K.; Casadei-Gardini, A.; Rovesti, G. BRCA in Gastrointestinal Cancers: Current Treatments and Future Perspectives. Cancers 2020, 12, 3346. https://doi.org/10.3390/cancers12113346
AMA Style
Molinaro E, Andrikou K, Casadei-Gardini A, Rovesti G. BRCA in Gastrointestinal Cancers: Current Treatments and Future Perspectives. Cancers. 2020; 12(11):3346. https://doi.org/10.3390/cancers12113346
Chicago/Turabian StyleMolinaro, Eleonora; Andrikou, Kalliopi; Casadei-Gardini, Andrea; Rovesti, Giulia. 2020. "BRCA in Gastrointestinal Cancers: Current Treatments and Future Perspectives" Cancers 12, no. 11: 3346. https://doi.org/10.3390/cancers12113346
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