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Article

Photoacoustic and Magnetic Resonance Imaging of Hybrid Manganese Dioxide-Coated Ultra-Small NaGdF4 Nanoparticles for Spatiotemporal Modulation of Hypoxia in Head and Neck Cancer

1
Center for Oral Oncology, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, USA
2
Department of Chemistry and the Institute for Lasers, Photonics, and Biophotonics, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA
3
Department of Medicine, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA
4
Department of Anesthesiology, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA
5
Department of Dentistry and Maxillofacial Prosthetics, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, USA
*
Authors to whom correspondence should be addressed.
Present affiliation: Fujifilm Visualsonics Corporation, Toronto, ON, Canada.
Present affiliation: Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Cancers 2020, 12(11), 3294; https://doi.org/10.3390/cancers12113294
Received: 24 August 2020 / Revised: 29 October 2020 / Accepted: 31 October 2020 / Published: 6 November 2020
(This article belongs to the Special Issue Novel Perspectives on Hypoxia in Cancer)
Tumor hypoxia is a documented negative prognostic factor that contributes to treatment resistance in head and neck cancer. In the present study, we use non-invasive magnetic resonance imaging (MRI) and photoacoustic imaging (PAI) to evaluate the ability of ultra-small manganese dioxide coated nanoparticles to modulate tumor oxygenation in vitro and in vivo. Our results highlight the utility of MRI and PAI in mapping tumor hypoxia and nanoparticle delivery and demonstrate the potential of image-guided nanodelivery in alleviating tumor hypoxia in head and neck cancer.
There is widespread interest in developing agents to modify tumor hypoxia in head and neck squamous cell carcinomas (HNSCC). Here, we report on the synthesis, characterization, and potential utility of ultra-small NaYF4:Nd3+/NaGdF4 nanocrystals coated with manganese dioxide (usNP-MnO2) for spatiotemporal modulation of hypoxia in HNSCC. Using a dual modality imaging approach, we first visualized the release of Mn2+ using T1-weighted magnetic resonance imaging (MRI) and modulation of oxygen saturation (%sO2) using photoacoustic imaging (PAI) in vascular channel phantoms. Combined MRI and PAI performed in patient-derived HNSCC xenografts following local and systemic delivery of the hybrid nanoparticles enabled mapping of intratumoral nanoparticle accumulation (based on T1 contrast enhancement) and improvement in tumor oxygenation (increased %sO2) within the tumor microenvironment. Our results demonstrate the potential of hybrid nanoparticles for the modulation of tumor hypoxia in head and neck cancer. Our findings also highlight the potential of combined MRI-PAI for simultaneous mapping nanoparticle delivery and oxygenation changes in tumors. Such imaging methods could be valuable in the precise selection of patients that are likely to benefit from hypoxia-modifying nanotherapies. View Full-Text
Keywords: head and neck cancer; tumor hypoxia; photoacoustic imaging; MRI; manganese dioxide nanoparticles head and neck cancer; tumor hypoxia; photoacoustic imaging; MRI; manganese dioxide nanoparticles
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MDPI and ACS Style

Rich, L.J.; Damasco, J.A.; Bulmahn, J.C.; Kutscher, H.L.; Prasad, P.N.; Seshadri, M. Photoacoustic and Magnetic Resonance Imaging of Hybrid Manganese Dioxide-Coated Ultra-Small NaGdF4 Nanoparticles for Spatiotemporal Modulation of Hypoxia in Head and Neck Cancer. Cancers 2020, 12, 3294. https://doi.org/10.3390/cancers12113294

AMA Style

Rich LJ, Damasco JA, Bulmahn JC, Kutscher HL, Prasad PN, Seshadri M. Photoacoustic and Magnetic Resonance Imaging of Hybrid Manganese Dioxide-Coated Ultra-Small NaGdF4 Nanoparticles for Spatiotemporal Modulation of Hypoxia in Head and Neck Cancer. Cancers. 2020; 12(11):3294. https://doi.org/10.3390/cancers12113294

Chicago/Turabian Style

Rich, Laurie J., Jossana A. Damasco, Julia C. Bulmahn, Hilliard L. Kutscher, Paras N. Prasad, and Mukund Seshadri. 2020. "Photoacoustic and Magnetic Resonance Imaging of Hybrid Manganese Dioxide-Coated Ultra-Small NaGdF4 Nanoparticles for Spatiotemporal Modulation of Hypoxia in Head and Neck Cancer" Cancers 12, no. 11: 3294. https://doi.org/10.3390/cancers12113294

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