Next Article in Journal
Myeloma Cells Deplete Bone Marrow Glutamine and Inhibit Osteoblast Differentiation Limiting Asparagine Availability
Previous Article in Journal
Patient-Reported Outcomes of Palbociclib Plus Exemestane with GnRH Agonist versus Capecitabine in Premenopausal Women with Hormone Receptor-Positive Metastatic Breast Cancer: A Prospective, Open-Label, Randomized Phase ll Trial (KCSG-BR 15-10)
Review

SARS-CoV-2 Infection in Cancer Patients: Effects on Disease Outcomes and Patient Prognosis

1
Department of Biology, College of Arts and Sciences, Georgia State University, Atlanta, GA 30303, USA
2
Maulana Azad Medical College and Associated Lok Nayak Hospital, New Delhi 110002, India
3
Department of Surgery, Maulana Azad Medical College and Associated Lok Nayak Hospital, New Delhi 110002, India
*
Author to whom correspondence should be addressed.
Cancers 2020, 12(11), 3266; https://doi.org/10.3390/cancers12113266
Received: 9 September 2020 / Revised: 19 October 2020 / Accepted: 3 November 2020 / Published: 5 November 2020
(This article belongs to the Section Systematic Review or Meta-Analysis in Cancer Research)
Cancer patients are a highly vulnerable subgroup in this coronavirus disease 2019 (COVID-19) pandemic. This crisis has dramatically disrupted the continuous care provided to cancer patients, as well as diagnostic and therapeutic procedures. Thus, studies that help gain insights into COVID-19 prevalence, disease severity, prognosis, and clinical outcomes in cancer patients are of great importance. In this review, we outline the current knowledge of disease outcomes and prognoses for cancer patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and learn if the severity is exacerbated by cancer type, anticancer therapies, gender, behavioral risk factors (e.g., smoking, alcohol consumption), and comorbidities. Our article will help clinicians determine cases where treatment can be postponed during the pandemic and will encourage further research to better understand the impact of SARS-CoV-2 infection on cancer patients.
The severity of coronavirus disease 2019 (COVID-19) symptoms and outcomes vary immensely among patients. Predicting disease progression and managing disease symptoms is even more challenging in cancer patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Cancer therapies, including chemotherapy, radiotherapy, and immunotherapy, often suppress the immune system, rendering cancer patients more susceptible to SARS-CoV-2 infection and the development of severe complications. However, data on the effects of immunosuppression on COVID-19 outcomes in cancer patients remain limited. Further investigations are warranted to better understand the implications of SARS-CoV-2 infection in cancer patients, particularly those that are immunocompromised. In this review, we outline the current knowledge of the effects of SARS-CoV-2 infection in cancer patients. View Full-Text
Keywords: COVID-19; SARS-CoV-2; cancer prognosis; immunosuppression COVID-19; SARS-CoV-2; cancer prognosis; immunosuppression
Show Figures

Graphical abstract

MDPI and ACS Style

Seth, G.; Sethi, S.; Bhattarai, S.; Saini, G.; Singh, C.B.; Aneja, R. SARS-CoV-2 Infection in Cancer Patients: Effects on Disease Outcomes and Patient Prognosis. Cancers 2020, 12, 3266. https://doi.org/10.3390/cancers12113266

AMA Style

Seth G, Sethi S, Bhattarai S, Saini G, Singh CB, Aneja R. SARS-CoV-2 Infection in Cancer Patients: Effects on Disease Outcomes and Patient Prognosis. Cancers. 2020; 12(11):3266. https://doi.org/10.3390/cancers12113266

Chicago/Turabian Style

Seth, Gaurav, Saira Sethi, Shristi Bhattarai, Geetanjali Saini, Chandra B. Singh, and Ritu Aneja. 2020. "SARS-CoV-2 Infection in Cancer Patients: Effects on Disease Outcomes and Patient Prognosis" Cancers 12, no. 11: 3266. https://doi.org/10.3390/cancers12113266

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop