Next Article in Journal
Long-Term Outcomes after Use of Perioperative Glucocorticoids in Patients Undergoing Cancer Surgery: A Systematic Review and Meta-Analysis
Previous Article in Journal
A Phase 1B Clinical Study of Combretastatin A1 Diphosphate (OXi4503) and Cytarabine (ARA-C) in Combination (OXA) for Patients with Relapsed or Refractory Acute Myeloid Leukemia
cancers-logo
Article Menu

Article Menu

Open AccessArticle

A Case-Control Analysis of the Impact of Venous Thromboembolic Disease on Quality of Life of Patients with Cancer: Quality of Life in Cancer (Qca) Study

1
Respiratory Department, Medical Surgical Unit of Respiratory Diseases, Hospital Virgen del Rocio, CIBERES, 41013 Sevilla, Spain
2
Medical Oncology Department, Hospital General Universitario Gregorio Marañón, 28009 Madrid, Spain
3
Hematology and Hemotherapy Department, Hospital Universitario Virgen de Valme, 41701 Sevilla, Spain
4
Medical Oncology Department, HGU de Ciudad Real, 13003 Ciudad Real, Spain
5
Medical Oncology Department, Hospital Universitario Virgen Macarena, 41009 Sevilla, Spain
6
Medical Oncology Department, DIBAPS/Translational Genomics and Targeted Therapeutics in Solid Tumors, Hospital Clínic, 08036 Barcelona, Spain
7
Emergency Department, Hospital Virgen Macarena, 41009 Sevilla, Spain
8
Medical Oncology Department, Hospital Universitario Central de Asturias, 33611 Oviedo, Spain
9
Medical Oncology Department, Hospital de Orense, 32616 Orense, Spain
10
Medical Oncology Department, Hospital de Jerez de la Frontera, 11407 Cádiz, Spain
11
Medical Oncology Department, H. U. Puerto Real, 11510 Cádiz, Spain
12
Respiratory Department, Hospital de Galdakao-Usansolo, 48960 Bizkaia, Spain
13
Internal Medicine Unit. H. U. Puerto Real, 11510 Cádiz, Spain
14
Medical Oncology Department, Hospital Virgen del Rocio, 41013 Sevilla, Spain
15
Respiratory Department, Hospital Universitario Virgen de Valme, 41701 Sevilla, Spain
*
Author to whom correspondence should be addressed.
Cancers 2020, 12(1), 75; https://doi.org/10.3390/cancers12010075
Received: 4 December 2019 / Revised: 22 December 2019 / Accepted: 24 December 2019 / Published: 26 December 2019
Although there is published research on the impact of venous thromboembolism (VTE) on quality of life (QoL), this issue has not been thoroughly investigated in patients with cancer—particularly using specific questionnaires. We aimed to examine the impact of acute symptomatic VTE on QoL of patients with malignancies. This was a multicenter, prospective, case-control study conducted in patients with cancer either with (cases) or without (controls) acute symptomatic VTE. Participants completed the EORTC QLQ-C30, EQ-5D-3L, PEmb-QoL, and VEINES-QOL/Sym questionnaires. Statistically significant and clinically relevant differences in terms of global health status were examined. Between 2015 and 2018, we enrolled 425 patients (128 cases and 297 controls; mean age: 60.2 ± 18.4 years). The most common malignancies were gastrointestinal (23.5%) and lung (19.8%) tumors. We found minimally important differences in global health status on the EQ-5D-3L (cases versus controls: 0.55 versus 0.77; mean difference: −0.22) and EORTC QLQ-C30 (47.7 versus 58.4; mean difference: −10.3) questionnaires. There were minimally important differences on the PEmb-QoL questionnaire (44.4 versus 23; mean difference: −21.4) and a significantly worse QoL on the VEINES-QOL/Sym questionnaire (42.7 versus 51.7; mean difference: −9). In conclusion, we showed that acute symptomatic VTE adversely affects the QoL of patients with malignancies. View Full-Text
Keywords: neoplasm; quality of life; venous thromboembolism; pulmonary embolism; venous thrombosis neoplasm; quality of life; venous thromboembolism; pulmonary embolism; venous thrombosis
Show Figures

Figure 1

MDPI and ACS Style

Marin-Barrera, L.; Muñoz-Martin, A.J.; Rios-Herranz, E.; Garcia-Escobar, I.; Beato, C.; Font, C.; Oncala-Sibajas, E.; Revuelta-Rodriguez, A.; Areses, M.C.; Rivas-Jimenez, V.; Moreno-Santos, M.A.; Ballaz-Quincoces, A.; Lopez-Saez, J.-B.; Gallego, I.; Elias-Hernandez, T.; Asensio-Cruz, M.I.; Chasco-Eguilaz, L.; Garcia-Gonzalez, G.; Estevez-Garcia, P.; Otero, R.; Lima-Alvarez, J.; Jara-Palomares, L. A Case-Control Analysis of the Impact of Venous Thromboembolic Disease on Quality of Life of Patients with Cancer: Quality of Life in Cancer (Qca) Study. Cancers 2020, 12, 75. https://doi.org/10.3390/cancers12010075

AMA Style

Marin-Barrera L, Muñoz-Martin AJ, Rios-Herranz E, Garcia-Escobar I, Beato C, Font C, Oncala-Sibajas E, Revuelta-Rodriguez A, Areses MC, Rivas-Jimenez V, Moreno-Santos MA, Ballaz-Quincoces A, Lopez-Saez J-B, Gallego I, Elias-Hernandez T, Asensio-Cruz MI, Chasco-Eguilaz L, Garcia-Gonzalez G, Estevez-Garcia P, Otero R, Lima-Alvarez J, Jara-Palomares L. A Case-Control Analysis of the Impact of Venous Thromboembolic Disease on Quality of Life of Patients with Cancer: Quality of Life in Cancer (Qca) Study. Cancers. 2020; 12(1):75. https://doi.org/10.3390/cancers12010075

Chicago/Turabian Style

Marin-Barrera, Lucia; Muñoz-Martin, Andres J.; Rios-Herranz, Eduardo; Garcia-Escobar, Ignacio; Beato, Carmen; Font, Carme; Oncala-Sibajas, Estefania; Revuelta-Rodriguez, Alfonso; Areses, Maria C.; Rivas-Jimenez, Victor; Moreno-Santos, Maria A.; Ballaz-Quincoces, Aitor; Lopez-Saez, Juan-Bosco; Gallego, Iria; Elias-Hernandez, Teresa; Asensio-Cruz, Maria I.; Chasco-Eguilaz, Leyre; Garcia-Gonzalez, Gonzalo; Estevez-Garcia, Purificacion; Otero, Remedios; Lima-Alvarez, Jorge; Jara-Palomares, Luis. 2020. "A Case-Control Analysis of the Impact of Venous Thromboembolic Disease on Quality of Life of Patients with Cancer: Quality of Life in Cancer (Qca) Study" Cancers 12, no. 1: 75. https://doi.org/10.3390/cancers12010075

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop